Mouse Interleukin-2 Receptor αGene Expression

Basic local alignment search tool

1990 • 87,358 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

A comprehensive set of sequence analysis programs for the VAX

1984 • 14,824 citations

[19] Rapid and efficient site-specific mutagenesis without phenotypic selection

1987 • 5,413 citations

Function and Activation of NF-kappaB in the Immune System

1994 • 4,698 citations

Rapid detection of octamer binding proteins with ‘mini extracts’, prepared from a small number of cells

1989 • 4,279 citations

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

1991 • 3,819 citations

[5] Rapid and sensitive sequence comparison with FASTP and FASTA

1990 • 1,983 citations

High gradient magnetic cell separation with MACS

1990 • 1,648 citations

NUCLEASE HYPERSENSITIVE SITES IN CHROMATIN

1988 • 1,233 citations

Weight matrix descriptions of four eukaryotic RNA polymerase II promoter elements derived from 502 unrelated promoter sequences

1990 • 1,140 citations

T cell growth factor receptors. Quantitation, specificity, and biological relevance

1981 • 1,087 citations

The inducible transcription activator NF-κB: regulation by distinct protein subunits

1991 • 1,079 citations

The Interleukin-2 T-Cell System: A New Cell Growth Model

1984 • 935 citations

A 5′ element of the chicken β-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila

1993 • 858 citations

Chromatin as an essential part of the transcriptional mechanim

1992 • 853 citations

Immunoglobulin gene transcription is activated by downstream sequence elements

1983 • 830 citations

Early steps of lymphocyte activation bypassed by synergy between calcium ionophores and phorbol ester

1985 • 753 citations

Sequence relationships between putative T-cell receptor polypeptides and immunoglobulins

1984 • 719 citations

Expression of interleukin-2 receptors as a differentiation marker on intrathymic stem cells

1985 • 613 citations

HTLV-1 transactivator induces interleukin-2 receptor expression through an NF-κB-like factor

1988 • 607 citations

The IL-2 Receptor Complex: Its Structure, Function, and Target Genes

1993 • 601 citations

Protein traffic on the heat shock promoter: Parking, stalling, and trucking along

1993 • 507 citations

Direct interaction between fos and jun nuclear oncoproteins: role of the 'leucine zipper' domain

1988 • 455 citations

Interleukin 2 regulates its own receptors.

1985 • 414 citations

Rapid and quantitative preparation of cytoplasmic RNA from small numbers of cells

1988 • 406 citations

The formation and function of DNase I hypersensitive sites in the process of gene activation.

1988 • 394 citations

Human GATA-3: a lineage-restricted transcription factor that regulates the expression of the T cell receptor alpha gene.

1991 • 364 citations

A sensitive method for the determination of protein-DNA binding specificities

1990 • 346 citations

Cytoplasmic domains of the interleukin-2 receptor β and γ chains mediate the signal for T-cell proliferation

1994 • 340 citations

Heterodimerization of the IL-2 receptor β- and γ-chain cytoplasmic domains is required for signalling

1994 • 338 citations

The nucleotide sequence of the chick cytoplasmic β-actin gene

1983 • 336 citations

THE MULTI-SUBUNIT INTERLEUKIN-2 RECEPTOR

1989 • 323 citations

Scaffold-associated regions: cis-acting determinants of chromatin structural loops and functional domains

1992 • 319 citations

Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor delta gene enhancer.

1991 • 316 citations

Sequential expression of genes involved in human T lymphocyte growth and differentiation.

1985 • 291 citations

ANTIGENS OF LEUKEMIAS INDUCED BY NATURALLY OCCURRING MURINE LEUKEMIA VIRUS: THEIR RELATION TO THE ANTIGENS OF GROSS VIRUS AND OTHER MURINE LEUKEMIA VIRUSES

1966 • 287 citations

IL-2 receptor α chain (CD25JAC) expression defines a crucial stage in pre-B cell development

1994 • 284 citations

Interleukin 2 (IL-2) augments transcription of the IL-2 receptor gene.

1985 • 280 citations

Regulation of Cell-Type-Specific Interleukin-2 Receptor α-Chain Gene Expression: Potential Role of Physical Interactions between Elf-1, HMG-I(Y), and NF-κ B Family Proteins

1995 • 244 citations

Tumor necrosis factor alpha induces proteins that bind specifically to kappa B-like enhancer elements and regulate interleukin 2 receptor alpha-chain gene expression in primary human T lymphocytes.

1989 • 230 citations

Structure of the Human Interleukin-2 Receptor Gene

1985 • 219 citations

Expression and function of interleukin-2 receptors on immature thymocytes

1985 • 217 citations

Activation of JAK kinases and STAT proteins by interleukin-2 and interferon alpha, but not the T cell antigen receptor, in human T lymphocytes.

1994 • 211 citations

High and low affinity IL 2 receptors: analysis by IL 2 dissociation rate and reactivity with monoclonal anti-receptor antibody PC61.

1985 • 203 citations

Functionally Distinct NF-κB Binding Sites in the Immunoglobulin κ and IL-2 Receptor α Chain Genes

1989 • 194 citations

Accessory cell independent proliferation of human T4 cells stimulated by immobilized monoclonal antibodies to CD3.

1987 • 188 citations

Transcriptional regulation of multigene loci: multilevel control

1993 • 187 citations

A permeable animal cell preparation for studying macromolecular synthesis. DNA synthesis and the role of deoxyribonucleotides in S phase initiation

1978 • 178 citations

A T-cell specific TCR delta DNA binding protein is a member of the human GATA family.

1991 • 178 citations

Lymphocyte Development from Stem Cells

1992 • 170 citations

A novel monoclonal antibody against murine IL-2 receptor beta-chain. Characterization of receptor expression in normal lymphoid cells and EL-4 cells.

1991 • 158 citations

Comparison of cloned rabbit and mouse β-globin genes showing strong evolutionary divergence of two homologous pairs of introns

1978 • 156 citations

Mechanism of Interleukin-2 Signaling: Mediation of Different Outcomes by a Single Receptor and Transduction Pathway

1989 • 148 citations

Cell specificity of granzyme gene expression.

1990 • 136 citations

The variability in activity of the universally expressed human cytomegalovirus immediate early gene 1 enhancer/promoter in transgenic mice

1991 • 136 citations

In vivo gene delivery. Efficient transfection of T lymphocytes in adult mice

1993 • 129 citations

Reconstitution of functional interleukin 2 receptor complexes on fibroblastoid cells: involvement of the cytoplasmic domain of the gamma chain in two distinct signaling pathways.

1993 • 114 citations

Interleukin 2 upregulates expression of its receptor on a T cell clone.

1985 • 102 citations

Monoclonal antibodies identify three epitope clusters on the mouse p55 subunit of the interleukin 2 receptor: relationship to the interleukin 2‐binding site

1987 • 93 citations

Hybrids between rat lymphoma and mouse T cells with inducible cytolytic activity

1982 • 81 citations

Control of T lymphocyte activation and IL-2 receptor expression by endogenously secreted lymphokines.

1994 • 78 citations

T-cell-replacing factor (interleukin 5) induces expression of interleukin 2 receptors on murine splenic B cells.

1987 • 73 citations

The gene encoding IFP 53/tryptophanyl-tRNA synthetase is regulated by the gamma-interferon activation factor

1993 • 71 citations

Cell surface marker analysis of mouse thymic dendritic cells

1992 • 71 citations

Receptor to nucleus signaling by prolactin and interleukin 2 via activation of latent DNA-binding factors.

1994 • 70 citations

Regulation of interleukin 2 receptor alpha subunit (Tac or CD25 antigen) gene expression: binding of inducible nuclear proteins to discrete promoter sequences correlates with transcriptional activation.

1988 • 68 citations

The same 50-kDa cellular protein binds to the negative regulatory elements of the interleukin 2 receptor alpha-chain gene and the human immunodeficiency virus type 1 long terminal repeat.

1989 • 67 citations

Characterization of cDNAs encoding the murine interleukin 2 receptor (IL-2R) gamma chain: chromosomal mapping and tissue specificity of IL-2R gamma chain expression.

1993 • 65 citations

Mouse Interleukin-2 Receptor α Gene Expression

1995 • 62 citations

Control of IL-2 receptor-alpha expression by IL-1, tumor necrosis factor, and IL-2. Complex regulation via elements in the 5' flanking region.

1990 • 61 citations

Alterations in the amino-terminal third of mouse interleukin 2: effects on biological activity and immunoreactivity.

1986 • 61 citations

Functional status of interleukin 2 receptors expressed by immature (Lyt-2-/L3T4-) thymocytes.

1986 • 60 citations

A factor induced by differentiation signals in cells of the macrophage lineage binds to the gamma interferon activation site.

1994 • 60 citations

Heterogeneity of immature (Lyt-2-/L3T4-) thymocytes. Identification of four major phenotypically distinct subsets differing in cell cycle status and in vitro activation requirements.

1988 • 57 citations

A single amino-acid substitution in the Ets domain alters core DNA binding specificity of Ets1 to that of the related transcription factors Elf1 and E74

1993 • 55 citations

Characterization of soluble factors that induce the cytolytic activity and the expression of T cell growth factor receptors of a T cell hybrid.

1984 • 54 citations

Cell cycle regulation of cloned cytolytic T cells by T cell growth factor: analysis by flow microfluorometry.

1982 • 51 citations

IL-2 receptor α chain expression during early B lymphocyte differentiation

1994 • 50 citations

Antigenic stimulation regulates the expression of IL 2 receptors in a cytolytic T lymphocyte clone.

1985 • 49 citations

Activation of T lymphocytes by lectins and carbohydrate-oxidizing reagents viewed as an immunological recognition of cell-surface modifications seen in the context of “self” major histocompatibility complex antigens

1981 • 47 citations

A simpler and better method to cleave chromatin with DNase1 for hypersensitive site analyses

1991 • 46 citations

Regulation of interleukin 2 (IL2) receptor expression: IL 2 as an inducing signal for the expression of its own receptor on a murine T helper cell line

1985 • 44 citations

The same target sequences are differentially important for activation of the interleukin 2 receptor alpha-chain gene in two distinct T-cell lines.

1990 • 41 citations

Evolution of the Rh polymorphism: a model for the interaction of incompatibility, reproductive compensation, and heterozygote advantage.

1969 • 39 citations

Rat × Mouse T‐cell Hybrids with Inducible Specific Cytolytic Activity

1983 • 39 citations

Delineation of an enhancerlike positive regulatory element in the interleukin-2 receptor alpha-chain gene.

1990 • 37 citations

A promoter element that exerts positive and negative control of the interleukin 2-responsive J-chain gene.

1992 • 36 citations

Regulation of the IL-2 receptor alpha-gene. Interaction of a kappa B binding protein with cell-specific transcription factors.

1989 • 35 citations

IL-2 promoter-driven lacZ expression as a monitoring tool for IL-2 expression in primary T cells of transgenic mice

1994 • 35 citations

The human IL-2 receptor gene contains a positive regulatory element that functions in cultured cells and cell-free extracts.

1987 • 34 citations

A novel interferon-alpha-regulated, DNA-binding protein participates in the regulation of the IFP53/tryptophanyl-tRNA synthetase gene.

1994 • 33 citations

Immunohistochemical localization of cells reacting with monoclonal antibodies directed against the interleukin-2 receptor of murine, rat and human origin.

1985 • 30 citations

Evidence for clonal anergy as a mechanism responsible for the maintenance of transplantation tolerance

1993 • 29 citations

In situnucleoprotein structure involving origin-proximal SV40 DNA control elements

1990 • 26 citations

Activity and interleukin 1 responsiveness of SV40 enhancer motifs in a rodent immature T cell line.

1990 • 26 citations

Regulation of perforin gene expression in a T cell hybrid with inducible cytolytic activity

1993 • 25 citations

A second sequence element located 3' to the NF-kappa B-binding site regulates IL-2 receptor-alpha gene induction.

1989 • 24 citations

Perinatal activation of a tyrosine aminotransferase fusion gene does not occur in albino lethal mice

1993 • 23 citations

A PCR-based assay for reporter gene expression.

1992 • 20 citations

Interleukins (IL)‐1 and IL‐2 control IL‐2 receptor α and β expression in immature thymocytes

1994 • 19 citations

IL-2-dependent proliferation of thymic accessory cells.

1988 • 17 citations

Different behavior of chromatin domains encompassing fibroin heavy-chain gene in active, temporarily inactive, and permanently inactive transcriptional states in silk gland nuclei.

1993 • 16 citations

Induction of mouse p55 interleukin-2 receptor gene expression by IL-2 and IL-4 and characterization of its transcription initiation sites

1991 • 15 citations

The non-histone proteins of the rat liver nucleus and their distribution amongst chromatin fractions as produced by nuclease digestion

1979 • 15 citations

Costimulation by interleukin‐1 of multiple activation responses in a developmentally restricted subset of immature thymocytes

1994 • 14 citations

Characterization of a New Tissue-Specific Transcription Factor Binding to the Simian Virus 40 Enhancer TC-II (NF-κB) Element

1992 • 12 citations

Interleukin 1 and tumor necrosis factor enhance transcription from the SV40 early promoter in a T cell line

1989 • 11 citations

Minimal growth requirements of mature T lymphocytes: interleukin (IL)‐1 and IL‐6 increase growth rate but not plating efficiency of CD4 cells stimulated with anti‐CD3 and IL‐2

1992 • 10 citations

Activation of immunoglobulin control elements in trasgenic mice

1992 • 9 citations