Human 3-hydroxy-3-methylglutaryl coenzyme A reductase. Conserved domains responsible for catalytic activity and sterol-regulated degradation.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

[2] New M13 vectors for cloning

1983 • 5,402 citations

Principles of biochemistry

1978 • 5,242 citations

Screening λgt Recombinant Clones by Hybridization to Single Plaques in Situ

1977 • 4,696 citations

Colony hybridization: a method for the isolation of cloned DNAs that contain a specific gene.

1975 • 3,483 citations

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1983 • 1,639 citations

Transformation of mammalian cells with genes from procaryotes and eucaryotes

1979 • 1,474 citations

The human LDL receptor: A cysteine-rich protein with multiple Alu sequences in its mRNA

1984 • 1,386 citations

Multivalent feedback regulation of HMG CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth.

1980 • 1,195 citations

The isolation and characterization of linked δ- and β-globin genes from a cloned library of human DNA

1978 • 1,055 citations

A cDNA cloning vector that permits expression of cDNA inserts in mammalian cells.

1983 • 933 citations

The evolution of genes: the chicken preproinsulin gene

1980 • 725 citations

A comprehensive sequence analysis program for the IBM personal computer

1984 • 605 citations

Mevinolin and colestipol stimulate receptor-mediated clearance of low density lipoprotein from plasma in familial hypercholesterolemia heterozygotes.

1983 • 562 citations

Regulation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Activity in Cultured Human Fibroblasts

1974 • 545 citations

HMG CoA reductase: A negatively regulated gene with unusual promoter and 5′ untranslated regions

1984 • 523 citations

Isolation and nucleotide sequence of the gene encoding human rhodopsin.

1984 • 495 citations

Principles of biochemistry

1983 • 478 citations

Cloning and sequence analysis of calf cDNA and human genomic DNA encoding α-subunit precursor of muscle acetylcholine receptor

1983 • 433 citations

Regulatory role for hepatic low density lipoprotein receptors in vivo in the dog.

1981 • 424 citations

Membrane-bound domain of HMG CoA reductase is required for sterol-enhanced degradation of the enzyme

1985 • 384 citations

Domain structure of 3-hydroxy-3-methylglutaryl coenzyme A reductase, a glycoprotein of the endoplasmic reticulum.

1985 • 301 citations

Nucleotide sequence of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase, a glycoprotein of endoplasmic reticulum

1984 • 263 citations

Regulation of synthesis and degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase by low density lipoprotein and 25-hydroxycholesterol in UT-1 cells.

1982 • 203 citations

Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase and its mRNA in rat liver as studied with a monoclonal antibody and a cDNA probe.

1983 • 200 citations

Amplification of the gene for 3-hydroxy-3-methylglutaryl coenzyme A reductase, but not for the 53-kDa protein, in UT-1 cells.

1983 • 200 citations

Methods in membrane biology

1975 • 192 citations

cDNA cloning of the bovine low density lipoprotein receptor: feedback regulation of a receptor mRNA.

1983 • 168 citations

Mevalonolactone inhibits the rate of synthesis and enhances the rate of degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in rat hepatocytes.

1983 • 156 citations

Molecular cloning of 3-hydroxy-3-methylglutaryl coenzyme a reductase and evidence for regulation of its mRNA.

1982 • 147 citations

3-Hydroxy-3-methylglutaryl-CoA reductase: a transmembrane glycoprotein of the endoplasmic reticulum with N-linked "high-mannose" oligosaccharides.

1983 • 136 citations

Primary structure of delta subunit precursor of calf muscle acetylcholine receptor deduced from cDNA sequence

1985 • 134 citations

Sterols accelerate degradation of hamster 3-hydroxy-3-methylglutaryl coenzyme A reductase encoded by a constitutively expressed cDNA.

1985 • 129 citations

Alterations in the rates of synthesis and degradation of rat liver 3-hydroxy-3-methylglutaryl coenzyme A reductase produced by cholestyramine and mevinolin.

1983 • 117 citations

Regulation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase in Hepatoma Tissue Culture Cells by Serum Lipoproteins

1974 • 92 citations

Mutant clone of Chinese hamster ovary cells lacking 3-hydroxy-3 -methylglutaryl coenzyme A reductase.

1983 • 62 citations

Primary structure of β subunit precursor of calf muscle acetylcholine receptor deduced from cDNA sequence

1984 • 60 citations

3-hydroxy-3-methylglutaryl coenzyme A reductase in human liver microsomes: active and inactive forms and cross-reactivity with antibody against rat liver enzyme.

1984 • 58 citations

Dependence of the Circadian Rhythm of Hepatic β-Hydroxy-β-methylglutaryl Coenzyme A on Ribonucleic Acid Synthesis

1974 • 58 citations

Primary structure of horse erythrocyte glycophorin HA. its amino acid sequence has a unique homology with those of human and porcine erythrocyte glycophorins

1982 • 39 citations

Purification of 3-hydroxy-3-methylglutaryl coenzyme A reductase from human liver.

1982 • 17 citations

Isolation and immunological characterization of 3-hydroxy-3-methylglutaryl coenzyme A reductase from human liver

1982 • 8 citations