The p53 tumor‐suppressor gene and ras oncogene mutations in oral squamous‐cell carcinoma

TNM Classification of Malignant Tumours

1987 • 16,209 citations

ras oncogenes in human cancer: a review.

1989 • 5,116 citations

Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase

1988 • 4,259 citations

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1990 • 3,896 citations

The p53 tumour suppressor gene

1991 • 3,871 citations

ras GENES

1987 • 3,818 citations

Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction

1989 • 3,557 citations

Generation of single-stranded DNA by the polymerase chain reaction and its application to direct sequencing of the HLA-DQA locus.

1988 • 1,582 citations

Increased expression of mutant forms of p53 oncogene in primary lung cancer

1990 • 1,045 citations

p53 mutations in human lymphoid malignancies: association with Burkitt lymphoma and chronic lymphocytic leukemia.

1991 • 915 citations

The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines.

1991 • 857 citations

OPTIMIZATION OF PCRs

1990 • 632 citations

Mutations in the p53 gene are frequent in primary, resected non-small cell lung cancer. Lung Cancer Study Group.

1990 • 515 citations

p53 alteration is a common event in the spontaneous immortalization of primary BALB/c murine embryo fibroblasts.

1991 • 455 citations

High incidence of amplification of the epidermal growth factor receptor gene in human squamous carcinoma cell lines.

1986 • 370 citations

A dot-blot screening procedure for mutated ras oncogenes using synthetic oligodeoxynucleotides

1986 • 351 citations

Elevated P53 expression correlates with a history of heavy smoking in squamous cell carcinoma of the head and neck

1991 • 259 citations

High frequency mutation in codons 12 and 61 of H-ras oncogene in chewing tobacco-related human oral carcinoma in India

1991 • 241 citations

Most human squamous cell carcinomas in the oral cavity contain mutated p53 tumor-suppressor genes.

1992 • 237 citations

A point mutation at codon 13 of the N-ras oncogene in myelodysplastic syndrome

1987 • 231 citations

New human transforming genes detected by a tumorigenicity assay.

1984 • 217 citations

Variant sublines with different metastatic potentials selected in nude mice from human oral squamous cell carcinomas

1989 • 198 citations

Frequent amplification of the bcl-1 locus in head and neck squamous cell carcinomas.

1989 • 195 citations

Molecular cloning and in vitro expression of a cDNA clone for human cellular tumor antigen p53.

1985 • 174 citations

Mutations in the p53 gene are frequent in primary, resected non-small cell lung cancer

1991 • 173 citations

Transforming genes of human hematopoietic tumors: frequent detection of ras-related oncogenes whose activation appears to be independent of tumor phenotype.

1983 • 172 citations

Human cancer and cellular oncogenes

1987 • 159 citations

Amplification of the int-2 gene in human head and neck squamous cell carcinomas.

1990 • 140 citations

Elevated expression of the c-myc oncoprotein correlates with poor prognosis in head and neck squamous cell carcinoma.

1989 • 125 citations

Oncogene Amplification in Squamous Cell Carcinoma of the Oral Cavity

1989 • 115 citations

Low incidence of ras oncogene activation in human squamous cell carcinomas

1990 • 98 citations

Ras mutations in united kingdom examples of oral malignancies are infrequent

1991 • 98 citations

Identification and characterization of a p53 gene mutation in a human osteosarcoma cell line.

1989 • 94 citations

Cancer epidemiology: The Indian scene

1981 • 92 citations

Gene amplification and overexpression of epidermal growth factor receptor in squamous cell carcinoma of the head and neck

1992 • 77 citations

Human immunodeficiency viral DNA is readily found in lymph node biopsies from seropositive individuals. Analysis of fixed tissue using the polymerase chain reaction.

1989 • 61 citations

Expression of oncogenes in human tumours with special reference to the head and neck region

1987 • 51 citations

Activation of oncogenes in human oral cancer cells: a novel codon 13 mutation of c-H-ras-1 and concurrent amplifications of c-erbB-1 and c-myc.

1989 • 51 citations