Site-specific immunity to Leishmania major in SWR mice: the site of infection influences susceptibility and expression of the antileishmanial immune response

Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets.

1989 • 1,462 citations

Lymphokine Control of In Vivo Immunoglobulin Isotype Selection

1990 • 1,303 citations

IL-4 directs the development of Th2-like helper effectors.

1990 • 1,261 citations

The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice.

1992 • 1,029 citations

Deactivation of macrophages by transforming growth factor-β

1988 • 876 citations

Differential regulation of T helper phenotype development by interleukins 4 and 10 in an alpha beta T-cell-receptor transgenic system.

1992 • 762 citations

Immunoregulation of cutaneous leishmaniasis. T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens.

1988 • 713 citations

Cure of murine leishmaniasis with anti-interleukin 4 monoclonal antibody. Evidence for a T cell-dependent, interferon gamma-independent mechanism.

1990 • 629 citations

Natural killer cells are a source of interferon gamma that drives differentiation of CD4+ T cell subsets and induces early resistance to Leishmania major in mice.

1993 • 612 citations

Production of interferon gamma, interleukin 2, interleukin 4, and interleukin 10 by CD4+ lymphocytes in vivo during healing and progressive murine leishmaniasis.

1991 • 528 citations

IFN-gamma modulates the early development of Th1 and Th2 responses in a murine model of cutaneous leishmaniasis.

1991 • 526 citations

Macrophage deactivating factor and transforming growth factors-beta 1 -beta 2 and -beta 3 inhibit induction of macrophage nitrogen oxide synthesis by IFN-gamma.

1990 • 507 citations

Establishment of Stable, Cell-Mediated Immunity that Makes "Susceptible" Mice Resistant to Leishmania major

1992 • 503 citations

Role of T‐Cell Derived Cytokines in the Downregulation of Immune Responses in Parasitic and Retroviral Infection

1992 • 473 citations

Transforming Growth Factor-β in Leishmanial Infection: a Parasite Escape Mechanism

1992 • 439 citations

IL-4 induces a Th2 response in Leishmania major-infected mice.

1992 • 403 citations

Administration of monoclonal anti-IFN-gamma antibodies in vivo abrogates natural resistance of C3H/HeN mice to infection with Leishmania major.

1989 • 374 citations

The role of T-cell subsets and cytokines in the regulation of infection

1991 • 352 citations

Antiproliferative effect of IFN-gamma in immune regulation. III. Differential selection of TH1 and TH2 murine helper T lymphocyte clones using recombinant IL-2 and recombinant IFN-gamma.

1989 • 349 citations

Identification of cell surface carbohydrate and antigenic changes between noninfective and infective developmental stages of Leishmania major promastigotes.

1985 • 338 citations

Therapeutic effect of anti-L3T4 monoclonal antibody GK1.5 on cutaneous leishmaniasis in genetically-susceptible BALB/c mice.

1985 • 225 citations

Vaccination against cutaneous leishmaniasis in a murine model. I. Induction of protective immunity with a soluble extract of promastigotes.

1987 • 212 citations

Immunological regulation of experimental cutaneous leishmaniasis. IV. Prophylactic effect of sublethal irradiation as a result of abrogation of suppressor T cell generation in mice genetically susceptible to leishmania tropica

1981 • 199 citations

Suppressive effect of cyclosporin A on the development of Leishmania tropica-induced lesions in genetically susceptible BALB/c mice.

1986 • 138 citations

Macrophage activation to kill Leishmania major: activation of macrophages for intracellular destruction of amastigotes can be induced by both recombinant interferon-gamma and non-interferon lymphokines.

1985 • 127 citations

Higher frequency of Leishmania major-specific L3T4+ T cells in susceptible BALB/c as compared with resistant CBA mice.

1986 • 104 citations

Changes in the precursor frequencies of IL-4 and IFN-gamma secreting CD4+ cells correlate with resolution of lesions in murine cutaneous leishmaniasis.

1992 • 104 citations

Experimental cutaneous leishmaniasis. V. Protective immunity in subclinical and self-healing infection in the mouse.

1976 • 101 citations

Interleukin‐4 transgenic mice of resistant background are susceptible to Leishmania major infection

1993 • 95 citations

Effect of Temperature on Multiplication of Leishmania Amastigotes within Human Monocyte-Derived Macrophages in Vitro

1981 • 91 citations

Single gene control of resistance to cutaneous leishmaniasis in mice

1981 • 83 citations

Prophylactic immunization against experimental leishmaniasis. IV. Subcutaneous immunization prevents the induction of protective immunity against fatal Leishmania major infection.

1985 • 82 citations

IL-2 is necessary for the progression of leishmaniasis in susceptible murine hosts.

1993 • 80 citations

A sensitive immunochemical assay for biologically active MuIFN-γ

1987 • 79 citations

Immunological regulation and control of experimental leishmaniasis.

1986 • 76 citations

Susceptibility of inbred mice to Leishmania tropica infection: Correlation of susceptibility with in vitro defective macrophage microbicidal activities

1983 • 70 citations

Inbred mice as model hosts for cutaneous leishmaniasis

1984 • 62 citations

Thermosensitivity Patterns of Old vs. New World Cutaneous Strains of Leishmania Growing within Mouse Peritoneal Macrophages in Vitro

1983 • 60 citations

Prophylactic treatment of BALB/c mice with cyclosporine A and its analog B-5-49 enhances resistance to Leishmania major.

1986 • 53 citations

Experimental Cutaneous Leishmaniasis: Disseminated Leishmaniasis in Genetically Susceptible and Resistant Mice

1982 • 53 citations

Leishmania braziliensis and Leishmania mexicana: Experimental cutaneous infections in golden hamsters

1979 • 48 citations

The enhancing effect of interferon-beta and -gamma on the killing of Leishmania tropica major in human mononuclear phagocytes in vitro.

1986 • 44 citations

Standardization of the Chromium-51 Release, Cell-Mediated Cytotoxicity Assay: Cryopreservation of Mouse Effector and Target Cells2

1977 • 37 citations

Impaired macrophage leishmanicidal activity at cutaneous temperature

1985 • 32 citations

Mechanisms of immunity to leishmaniasis. IV. Significance of lymphatic drainage from the site of infection.

1982 • 30 citations

Rate ofLeishmania-induced skin-lesion development in rodents depends on the site of inoculation

1987 • 27 citations

Genetics of susceptibility and resistance in the vertebrate host.

1987 • 26 citations

Leishmania mexicana: Temperature sensitivity of isolated amastigotes and of amastigotes infecting macrophages in culture

1983 • 25 citations

Host factors influencing outcome of Leishmania mexicana infection in mice

1983 • 3 citations