Amyloid β₄₂Activates a G-Protein-Coupled Chemoattractant Receptor, FPR-Like-1

Inflammation and Alzheimer's disease

2000 • 4,315 citations

Diffusible, nonfibrillar ligands derived from Aβ _1–42 are potent central nervous system neurotoxins

1998 • 3,404 citations

RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease

1996 • 1,955 citations

Soluble pool of A? amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

1999 • 1,787 citations

Translating cell biology into therapeutic advances in Alzheimer's disease

1999 • 1,592 citations

The Molecular Biology of Leukocyte Chemoattractant Receptors

1994 • 1,224 citations

β-Amyloid-mediated vasoactivity and vascular endothelial damage

1996 • 686 citations

Identification of a human cDNA encoding a functional high affinity lipoxin A4 receptor.

1994 • 431 citations

A Seven-transmembrane, G Protein–coupled Receptor, FPRL1, Mediates the Chemotactic Activity of Serum Amyloid A for Human Phagocytic Cells

1999 • 425 citations

Amyloid-β peptide–Receptor for Advanced Glycation Endproduct interaction elicits neuronal expression of macrophage-colony stimulating factor: A proinflammatory pathway in Alzheimer disease

1997 • 416 citations

Identification of Microglial Signal Transduction Pathways Mediating a Neurotoxic Response to Amyloidogenic Fragments of β-Amyloid and Prion Proteins

1999 • 353 citations

Human serum amyloid A (SAA) protein: a prominent acute‐phase reactant for clinical practice

1996 • 344 citations

Association of Microglia with Amyloid Plaques in Brains of APP23 Transgenic Mice

1999 • 332 citations

β-Amyloid Activates the O⨪2 Forming NADPH Oxidase in Microglia, Monocytes, and Neutrophils

1999 • 325 citations

Amyloid Fibrils Activate Tyrosine Kinase-Dependent Signaling and Superoxide Production in Microglia

1997 • 318 citations

A central role for astrocytes in the inflammatory response to β-amyloid; chemokines, cytokines and reactive oxygen species are produced

1999 • 313 citations

The N-formyl peptide receptor: A model for the study of chemoattractant receptor structure and function

1997 • 254 citations

beta-Amyloid fibrils activate parallel mitogen-activated protein kinase pathways in microglia and THP1 monocytes.

1998 • 253 citations

Amyloid-beta induces chemokine secretion and monocyte migration across a human blood--brain barrier model.

1998 • 223 citations

High Levels of Circulating Aβ42 Are Sequestered by Plasma Proteins in Alzheimer's Disease

1999 • 183 citations

?-Amyloid protein enhances macrophage production of oxygen free radicals and glutamate

1997 • 165 citations

Microglia and Alzheimer’s disease

1999 • 133 citations

Species and subtype variants of the N-formyl peptide chemotactic receptor reveal multiple important functional domains.

1993 • 124 citations

A Synthetic Peptide Derived From Human Immunodeficiency Virus Type 1 gp120 Downregulates the Expression and Function of Chemokine Receptors CCR5 and CXCR4 in Monocytes by Activating the 7-Transmembrane G-Protein–Coupled Receptor FPRL1/LXA4R

1999 • 115 citations

Activation of nuclear factor-κB by β-amyloid peptides and interferon-γ in murine microglia

1997 • 113 citations

Interaction of Alzheimer β-amyloid peptide with the human monocytic cell line THP-1 results in a protein kinase C-dependent secretion of tumor necrosis factor-α

1997 • 109 citations

Beta-amyloid (25-35) peptide and IFN-gamma synergistically induce the production of the chemotactic cytokine MCP-1/JE in monocytes and microglial cells.

1996 • 103 citations

Alzheimer's β‐Amyloid Peptide 1–42 Induces a Phagocytic Response in Murine Microglia

1998 • 101 citations

The amyloid beta-protein of Alzheimer's disease is chemotactic for mononuclear phagocytes

1992 • 94 citations

Chemotactic-like receptors and Aβ peptide induced responses in Alzheimer's Disease

2000 • 73 citations

Elimination of the Class A Scavenger Receptor Does Not Affect Amyloid Plaque Formation or Neurodegeneration in Transgenic Mice Expressing Human Amyloid Protein Precursors

1999 • 66 citations

The Molecular Biology of Leukocyte Chemoattractant Receptors

1994 • 62 citations

Neurocytopathic effects of beta-amyloid-stimulated monocytes: a potential mechanism for central nervous system damage in Alzheimer disease.

1996 • 56 citations

β-Amyloid-induced IL-1β release from an activated human monocyte cell line is calcium- and G-protein-dependent

1997 • 47 citations

Protein kinase C and F‐actin are essential for stimulation of neuronal FAK tyrosine phosphorylation by G‐proteins and amyloid beta protein

1996 • 44 citations

PKC and tyrosine kinase involvement in amyloid β (25-35)-induced chemotaxis of microglia

1998 • 35 citations

Beta Amyloid Toxicity Does Not Require RAGE Protein

1997 • 35 citations

β(1–40) Amyloid peptide injection into the nucleus basalis of rats induces microglia reaction and enhances cortical γ-aminobutyric acid release in vivo

1999 • 29 citations

A Synthetic Peptide Derived From Human Immunodeficiency Virus Type 1 gp120 Downregulates the Expression and Function of Chemokine Receptors CCR5 and CXCR4 in Monocytes by Activating the 7-Transmembrane G-Protein–Coupled Receptor FPRL1/LXA4R

1999 • 15 citations