[10] Posttranslational enzymes in the biosynthesis of collagen: Intracellular enzymes

Modifications of a specific assay for hydroxyproline in urine

1967 • 1,091 citations

Modified procedure for the assay of H3- or C14-labeled hydroxyproline

1966 • 710 citations

Metabolism of Proline and the Hydroxyprolines

1980 • 510 citations

Collagen: Molecular Diversity in the Body's Protein Scaffold

1980 • 448 citations

Biochemistry of Collagen

1976 • 436 citations

The role of lipid intermediates in the glycosylation of proteins in the eucaryotic cell

1979 • 378 citations

A rapid assay for collagen proline hydroxylase

1966 • 333 citations

Synthesis and extrusion of collagen by freshly isolated cells from chick embryo tendon

1971 • 280 citations

Mechanism of the Prolyl Hydroxylase Reaction

1977 • 260 citations

Mechanism of the Prolyl Hydroxylase Reaction

1977 • 247 citations

The Enzymology of post-translational modification of proteins

1980 • 240 citations

The role of ascorbate in the prolyl hydroxylase reaction

1978 • 211 citations

Time lag in the secretion of collagen by matrix-free tendon cells and inhibition of the secretory process by colchicine and vinblastine

1972 • 197 citations

Affinity Column Purification of Protocollagen Proline Hydroxylase from Chick Embryos and Further Characterization of the Enzyme

1973 • 168 citations

Hydroxylation of Proline in Synthetic Polypeptides with Purified Protocollagen Hydroxylase

1967 • 167 citations

An Affinity‐Column Procedure Using Poly(<scp>l</scp>‐proline) for the Purification of Prolyl Hydroxylase

1975 • 167 citations

Purification and properties of collagen proline hydroxylase from newborn rat skin

1970 • 152 citations

Synthesis of Poly-(<scp>l</scp>-prolyl-<scp>l</scp>-prolylglycyl) of Defined Molecular Weights

1968 • 148 citations

Collagen in Health and Disease

1978 • 145 citations

Studies on the Biosynthesis of the Hydroxylysine-linked Disaccharide Unit of Basement Membranes and Collagens

1971 • 127 citations

The role of dolichol monophosphate in sugar transfer

1971 • 124 citations

Collagen Glycosyltransferases

1979 • 123 citations

Assay of Collagen‐Galactosyltransferase and Collagen‐Glucosyltransferase Activities and Preliminary Characterization of Enzymic Reactions with Transferases from Chick‐Embryo Cartilage

1975 • 122 citations

Purification of carbon-14-labeled protocollagen and its hydroxylation by prolyl-hydroxylase

1973 • 120 citations

Platelet collagen adhesion characterization of collagen glucosyltransferase of plasma membranes of human blood platelets

1971 • 108 citations

Platelet adhesiveness and aggregation: The collagen:Glycosyl, polypeptide:N-acetylgalactosaminyl and glycoprotein:Galactosyl transferases of human platelets

1971 • 107 citations

Purification and partial characterization of the enzyme for the hydroxylation of proline in protocollagen

1967 • 106 citations

A Comparative Study of Glycopeptides Derived from Selected Vertebrate Collagens

1970 • 101 citations

Modification of the tritium-release assays for prolyl and lysyl hydroxylases using Dowex-50 columns

1975 • 99 citations

A simple method for differential assay of tritium and carbon-14 in water-soluble biological materials

1963 • 95 citations

Isolation and partial characterization of highly purified protocollagen proline hydroxylase

1970 • 93 citations

Activities of prolyl hydroxylase, lysyl hydroxylase, collagen galactosyltransferase and collagen glucosyltransferase in the liver of rats with hepatic injury

1974 • 92 citations

Studies on the Biosynthesis of the Hydroxylysine-linked Disaccharide Unit of Basement Membranes and Collagens

1971 • 92 citations

Attachment of carbohydrate to collagen. Isolation, purification and properties of the glucosyl transferase

1968 • 92 citations

Partial purification and characterization of protocollagen lysine hydroxylase from chick embryos

1972 • 90 citations

Cell-free Collagen Synthesis on Membrane-bound Polysomes of Chick Embryo Connective Tissue and the Localization of Prolyl Hydroxylase on the Polysome-Membrane Complex

1973 • 85 citations

Protocollagen lysine hydroxylase. Hydroxylation of synthetic peptides and the stoichiometric decarboxylation of α-ketoglutarate

1972 • 83 citations

Further characterization of embryonic tendon fibroblasts and the use of immunoferritin techniques to study collagen biosynthesis.

1975 • 83 citations

Studies on the lysyl hydroxylase reaction. I. Initial velocity kinetics and related aspects

1980 • 79 citations

Intracellular enzymes of collagen biosynthesis in rat liver as a function of age and in hepatic injury induced by dimethylnitrosamine. Purification of rat prolyl hydroxylase and comparison of changes in prolyl hydroxylase activity with changes in immunoreactive prolyl hydroxylase

1976 • 77 citations

Studies on the lysyl hydroxylase reaction. II. Inhibition kinetics and the reaction mechanism

1980 • 77 citations

Studies on the Biosynthesis of the Hydroxylysine-linked Disaccharide Unit of Basement Membranes and Collagens

1971 • 75 citations

Human Prolyl Hydroxylase. Purification, Partial Characterization and Preparation of Antiserum to the Enzyme

1975 • 71 citations

Glycoprotein biosynthesis: The biosynthesis of the hydroxylysine-galactose linkage in collagen

1968 • 68 citations

Collagen biosynthesis enzymes in serum and hepatic tissue in liver disease

1979 • 67 citations

Collagen biosynthesis enzymes in serum and hepatic tissue in liver disease

1979 • 66 citations

Studies on the glycosylation of hydroxylysine residues during collagen biosynthesis and the subcellular localization of collagen galactosyltransferase and collagen glucosyltransferase in tendon and cartilage cells

1975 • 66 citations

Ascorbate increases the synthesis of procollagen hydroxyproline by cultured fibroblasts from chick embryo tendons without activation or prolyl hydroxylase

1975 • 66 citations

Prolyl 3‐Hydroxylase: Partial Characterization of the Enzyme from Rat Kidney Cortex

1977 • 62 citations

Prolyl hydroxylase and an immunologically related protein in mammalian tissues

1974 • 60 citations

Collagen Glucosyltransferase. Partial Purification and Characterization of the Enzyme from Whole Chick Embryos and Chick-Embryo Cartilage

1976 • 57 citations

Separation of prolyl 3-hydroxylase and 4-hydroxylase activities and the 4-hydroxyproline requirement for synthesis of 3-hydroxyproline

1977 • 56 citations

A Sensitive Microassay for Prolyl Hydroxylase: Activity in Normal and Psoriatic Skin

1973 • 56 citations

Purification and partial characterization of the two nonidentical subunits of prolyl hydroxylase.

1979 • 55 citations

Hydroxylation of (X-Pro-Gly)n by protocollagen proline hydroxylase Effect of chain length, helical conformation and amino acid sequence in the substrate

1972 • 54 citations

Radioimmunoassay for Human and Chick Prolyl Hydroxylases

1975 • 53 citations

Characterization of membrane-bound collagen galactosyltransferase of human blood platelets

1971 • 52 citations

Isolation of lysyl hydroxylase, an enzyme of collagen synthesis, from chick embryos as a homogeneous protein

1980 • 52 citations

Hydroxylation of lysine and glycosylation of hydroxylysine during collagen biosynthesis in isolated chick-embryo cartilage cells

1976 • 52 citations

Partial reaction of prolyl hydroxylase. (Gly-PRO-Ala)n stimulates alpha-ketoglutarate decarboxylation without prolyl hydroxylation.

1978 • 51 citations

The assembly of tetrameric prolyl hydroxylase in tendon fibroblasts from newly synthesized α-subunits and from preformed cross-reacting protein

1980 • 51 citations

Glucosylation of Galactosylhydroxylysyl Residues in Collagen in vitro by Collagen Glucosyltransferase

1975 • 51 citations

Immunoreactive prolyl hydroxylase in human skin, serum and synovial fluid: changes in the content and components with age

1977 • 49 citations

Intracellular Enzymes of Collagen Biosynthesis in Rat Kidney in Streptozotocin Diabetes

1976 • 48 citations

The function of ascorbate with respect to prolyl 4-hydroxylase activity

1981 • 48 citations

Factors which stimulate collagen proline hydroxylase

1967 • 48 citations

Hydroxylation of lysyl residues in native and denatured protocollagen by protocollagen lysyl hydroxylase in vitro

1974 • 46 citations

Protocollagen proline hydroxylase: Molecular weight, subunits and isoelectric point

1970 • 46 citations

Rapid assay for lysyl-protocollagen hydroxylase activity

1972 • 46 citations

Lysyl hydroxylase. Further purification and characterization of the enzume from chick embryos and chick embryo cartilage

1976 • 44 citations

A rapid assay for 14C-labeled hydroxylysine in collagen and related materials

1969 • 43 citations

Collagen glucosyltransferase activity in human serum

1977 • 42 citations

Partial purification and characterization of collagen galactosyltransferase from chick embryos

1976 • 42 citations

Partial purification and characterization of peptidyl proline hydroxylase precursor from mouse fibroblasts

1972 • 40 citations

The intracellular location of the glycosylation of hydroxylysine of collagen

1975 • 40 citations

Involvement of superoxide in the prolyl and lysyl hydroxylase reactions

1979 • 38 citations

Chromatographic separation of the enzymes required for hydroxylation of lysine and proline residues of protocollagen

1971 • 38 citations

Substrate specificity of collagen proline hydroxylase: Hydroxylation of a specific proline residue in bradykinin

1969 • 38 citations

Hydroxylation of proline and lysine in protocollagen involves two separate enzymatic sites

1969 • 38 citations

Affinity Chromatography of Collagen Glycosyltransferases on Collagen Linked to Agarose

1976 • 38 citations

Serum immunoreactive prolyl hydroxylase in liver disease

1977 • 37 citations

Evidence for free radical involvement in the hydroxylation of proline: Inhibition by nitro blue tetrazolium

1972 • 37 citations

Partial purification and characterization of chick-embryo prolyl 3-hydroxylase

1979 • 36 citations

Native collagen is not a substrate for the collagen glucosyltransferase of platelets

1976 • 34 citations

Association of prolyl hydroxylase activity with membranes

1973 • 34 citations

Human Lysyl Hydroxylase: Purification to Homogeneity, Partial Characterization and Comparison of Catalytic Properties with those of a Mutant Enzyme from Ehlers-Danlos Syndrome Type VI Fibroblasts

1981 • 34 citations

Affinity chromatography of collagen glucosyltransferase on a UDP-glucose derivative coupled to agarose

1976 • 32 citations

Properties of prolyl 4-hydroxylase containing firmly-bound iron

1980 • 32 citations

Isolation of collagen glucosyltransferase as a homogeneous protein from chick embryos

1977 • 32 citations

Developmental Changes in Prolyl Hydroxylase Activity and Protein in Chick Embryo

1976 • 31 citations

Structure of Protocollagen Proline Hydroxylase from Chick Embryos

1973 • 30 citations

Partial purification and properties of collagen lysine hydroxylase from chick embryos

1972 • 30 citations

Effect of L-azetidine-2-carboxylic acid on glycosylations of collagen in chick-embryo tendon cells

1976 • 30 citations

Procollagen polypeptides containing cis-4-hydroxy-l-proline are overglycosylated and secreted as nonhelical pro-γ-chains

1978 • 29 citations

Affinity chromatography of lysyl hydroxylase on concanavalin A-agarose

1977 • 29 citations

Stimulation of collagen galactosyltransferase and glucosyltransferase activities by lysophosphatidylcholine

1976 • 29 citations

Quantitative assay for hydroxylysine in protein hydrolyzates

1971 • 28 citations

A rapid assay for prolyl 3-hydroxylase activity

1978 • 28 citations

Turnover of prolyl hydroxylase tetramers and the monomer-size protein in chick-embryo cartilaginous bone and lung in vivo

1979 • 28 citations

Prolyl hydroxylase activity in L-929 fibroblasts incubated with and without ascorbate

1976 • 28 citations

Characterization of human platelet udpglucose-collagen glucosyltransferase using a new rapid assay

1977 • 28 citations

Regulation of collagen post-translational modification in transformed human and chick-embryo cells

1981 • 27 citations

A substance in L-929 cell extracts which replaces the ascorbate requirement for prolyl hydroxylase in a tritium release assay for reducing cofactor; correlation of its concentration with the extent of ascorbate-independent proline hydroxylation and the level of prolyl hydroxylase activity in these cells

1980 • 27 citations

Concanavalin a binds to purified prolyl hydroxylase and partially inhibits its enzymic activity

1976 • 27 citations

Tetramers and Monomers of Prolyl Hydroxylase in Isolated Chick-Embryo Tendon Cells. The Association of Inactive Monomers to Active Tetramers and a Preliminary Characterization of the Intracellular Monomer-Size Protein

1977 • 27 citations

Intracellular enzymes of collagen biosynthesis in rat kidney in streptozotocin diabetes

1976 • 25 citations

Studies on the Mechanism of Collagen Glucosyltransferase Reaction

1976 • 24 citations

Metal Activation of Galactosylhydroxylysyl Glucosyltransferase, an Intracellular Enzyme of Collagen Biosynthesis

1979 • 23 citations

Hydroxylation of (Pro-Pro-Gly)₅ and (Pro-Pro-Gly)₁₀ by prolyl hydroxylase. Evidence for an asymmetric active site in the enzyme

1977 • 22 citations

Enzymes of collagen biosynthesis in skin and serum in dermatological diseases

1979 • 22 citations

Intracellular enzymes of collagen biosynthesis in human platelets

1977 • 22 citations

Enzymes of collagen biosynthesis in skin and serum in dermatological diseases

1979 • 21 citations

Further characterization of galactosylhydroxylysyl glucosyltransferase from chick embryos. Amino acid composition and acceptor specificity

1978 • 21 citations

Studies on the stability of protocollagen hydroxylase

1968 • 21 citations

A general method for the rapid measurement of enzyme precursors by the displacement of enzyme from antibody: The measurement of collagen proline hydroxylase precursor in cultured fibroblasts

1972 • 20 citations

Localization of chick embryo limb bone microsomal lysyl hydroxylase at intracisternal and intramembrane sites.

1979 • 19 citations

CRP, immunologically cross-reacting protein of prolyl hydroxylase. Its role in assembly of active prolyl hydroxylase and cellular localization in L-929 fibroblasts

1980 • 19 citations

Hydrophobic and Carbohydrate-Recognition Chromatographies of Collagen Glucosyltransferase

1977 • 18 citations

Intracellular Enzymes of Collagen Biosynthesis in 3T6 Fibroblasts and Chick‐Embryo Tendon and Cartilage Cells

1979 • 17 citations

Further characterization of collagen galactosyltransferase from chick embryos

1978 • 17 citations

Purification and Properties of UDP-Glucose Galactosylhydroxylysine Collagen Glucosyltransferase (EC 2.4.1.?) from Bovine Arterial Tissue

1975 • 16 citations

Immunological characterization of lysyl hydroxylase, an enzyme of collagen synthesis

1981 • 16 citations

Cell density-dependent increase in prolyl hydroxylase activity in cultured L-929 cells requires de novo protein synthesis

1979 • 13 citations

Use of soluble, collagenous peptides from medium of chick calvaria cultures as substrate for prolyl hydroxylase

1980 • 12 citations

Serum immunoreactive prolyl hydroxylase in inflammatory rheumatic diseases.

1980 • 12 citations

Turnover of prolyl hydroxylase and an immunologically related protein in rabbit tissue

1979 • 9 citations

Regulation of the glycosylations of collagen hydroxylysine in chick embryo tendon and cartilage cells

1980 • 9 citations

The distribution of collagen:Glucosyltransferase in human blood cells and plasma

1980 • 8 citations

A modified assay system for collagen glucosyltransferase

1978 • 8 citations

Studies on the collagen glucosyltransferase activity present in platelets and plasma

1979 • 8 citations

Preparation of antibodies to chick-embryo galactosylhydroxylysyl glucosyltransferase and their use for an immunological characterization of the enzyme of collagen synthesis

1981 • 7 citations

Purification and enzymatic properties of lysyl hydroxylase from fetal porcine skin

1979 • 6 citations