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Hydroxylation of (Pro-Pro-Gly)5 and (Pro-Pro-Gly)10 by prolyl hydroxylase. Evidence for an asymmetric active site in the enzyme

Data up to Jan 2025

Published1977
Citations22
References34

Total Citations Per Year

Abstract

References (34)

Modifications of a specific assay for hydroxyproline in urine

1967 • 1,091 citations

Modified procedure for the assay of H3- or C14-labeled hydroxyproline

1966 • 710 citations

The thermal transition of a non-hydroxylated form of collagen. Evidence for a role for hydroxyproline in stabilizing the triple-helix of collagen

1973 • 563 citations

The Chemistry and Structure of Collagen

1971 • 555 citations

Mapping the active site of papain with the aid of peptide substrates and inhibitors

1970 • 410 citations

Use of Anhydrous Hydrogen Fluoride in Peptide Synthesis. I. Behavior of Various Protective Groups in Anhydrous Hydrogen Fluoride

1967 • 388 citations

Structural concepts in immunology and immunochemistry

1968 • 283 citations

The Biosynthesis of Collagen

1972 • 235 citations

Hydroxyproline content determines the denaturation temperature of chick tendon collagen

1973 • 224 citations

Affinity Column Purification of Protocollagen Proline Hydroxylase from Chick Embryos and Further Characterization of the Enzyme

1973 • 168 citations

Hydroxylation of Proline in Synthetic Polypeptides with Purified Protocollagen Hydroxylase

1967 • 167 citations

An Affinity‐Column Procedure Using Poly(<scp>l</scp>‐proline) for the Purification of Prolyl Hydroxylase

1975 • 167 citations

Synthesis of Poly-(<scp>l</scp>-prolyl-<scp>l</scp>-prolylglycyl) of Defined Molecular Weights

1968 • 148 citations

Procollagen: biological scission of amino and carboxyl extension peptides.

1975 • 132 citations

Amino acid analysis of stained bands from polyacrylamide gels

1971 • 121 citations

The steady state kinetic parameters and non-processivity of Escherichia coli deoxyribonucleic acid polymerase I

1975 • 120 citations

Purification of carbon-14-labeled protocollagen and its hydroxylation by prolyl-hydroxylase

1973 • 120 citations

Information contained in the amino acid sequence of theα1(I)-chain of collagen and its consequences upon the formation of the triple helix, of fibrils and crosslinks

1975 • 109 citations

Purification and partial characterization of the enzyme for the hydroxylation of proline in protocollagen

1967 • 106 citations

Mechanism of action of rat liver DNA methylase

1971 • 103 citations

Interchain disulfide bonds in procollagen are located in a large nontriple-helical COOH-terminal domain.

1975 • 99 citations

The binding and cleavage by lysozyme of N -acetylglucosamine oligosaccharides

1967 • 96 citations

Studies on the mechanism of enzymatic DNA elongation by Escherichia coli DNA polymerase II

1976 • 80 citations

Interchain disulfide bonds at the COOH-terminal end of procollagen synthesized by matrix-free cells from chick embryonic tendon and cartilage

1976 • 77 citations

Procollagen: Intermediate Forms Containing Several Types of Peptide Chains and Non-Collagen Peptide Extensions at NH 2 and COOH Ends

1974 • 68 citations

Formation of Enzyme-Substrate Complexes with Protocollagen Proline Hydroxylase and Large Polypeptide Substrates

1969 • 59 citations

Hydroxylation of (X-Pro-Gly)n by protocollagen proline hydroxylase Effect of chain length, helical conformation and amino acid sequence in the substrate

1972 • 54 citations

The substrate recognition site of collagen proline hydroxylase: The hydroxylation of -X-Pro-Gly- sequences in bradykinin analogs and other peptides

1971 • 46 citations

Titration and Melting Curves of the Collagen-like Triple Helices Formed from (Pro-Pro-Gly)10 in Aqueous Solution

1970 • 44 citations

Conformational change of the triple‐helical structure. III. Stabilizing forces in the triple helix

1974 • 21 citations

Conformational change of the triple‐helical structure. IV. Kinetics of the helix‐folding of (Pro‐Pro‐Gly)n (n = 10, 12, and 15)

1974 • 17 citations

Asymmetry in the hydroxylation of (Pro-Pro-Gly)5 by protocollagen proline hydroxylase

1971 • 17 citations

5 Enzymic Methylation of Natural Polynucleotides

1973 • 14 citations

MOLAR ABSORPTIVITY AND A1cm VALUES FOR PROTEINS AT SELECTED WAVELENGTHS OF THE ULTRAVIOLET AND VISIBLE REGION. II*

1971 • 11 citations

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Hydroxylation of (Pro-Pro-Gly)5 and (Pro-Pro-Gly)10 by prolyl hydroxylase. Evidence for… (1977) – Biochemistry | Metascience Observatory Explorer