Conversion of adrenergic mechanism from an alpha- to a beta-type during primary culture of rat hepatocytes. Accompanying decreases in the function of the inhibitory guanine nucleotide regulatory component of adenylate cyclase identified as the substrate of islet-activating protein.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

HIGH-YIELD PREPARATION OF ISOLATED RAT LIVER PARENCHYMAL CELLS

1969 • 4,428 citations

Biochemical Properties of Hormone-Sensitive Adenylate Cyclase

1980 • 1,016 citations

Direct modification of the membrane adenylate cyclase system by islet-activating protein due to ADP-ribosylation of a membrane protein.

1982 • 808 citations

An ultrasensitive method for the simultaneous determination of cyclic AMP and cyclic GMP in small-volume samples from blood and tissue

1977 • 679 citations

ADP ribosylation of the specific membrane protein of C6 cells by islet-activating protein associated with modification of adenylate cyclase activity.

1982 • 600 citations

Islet-activating protein, pertussis toxin: a probe for functions of the inhibitory guanine nucleotide regulatory component of adenylate cyclase

1984 • 567 citations

Rapid breakdown of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate in rat hepatocytes stimulated by vasopressin and other Ca2+-mobilizing hormones

1983 • 547 citations

Subunit structure of islet-activating protein, pertussis toxin, in conformity with the A-B model

1982 • 497 citations

Specific uncoupling by islet-activating protein, pertussis toxin, of negative signal transduction via alpha-adrenergic, cholinergic, and opiate receptors in neuroblastoma x glioma hybrid cells.

1983 • 493 citations

The inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. Properties and function of the purified protein.

1984 • 411 citations

Loss of the inhibitory function of the guanine nucleotide regulatory component of adenylate cyclase due to its ADP ribosylation by islet-activating protein, pertussis toxin, in adipocyte membranes.

1983 • 406 citations

ADP-ribosylation of the specific membrane protein by islet-activating protein, pertussis toxin, associated with inhibition of a chemotactic peptide-induced arachidonate release in neutrophils. A possible role of the toxin substrate in Ca2+-mobilizing biosignaling.

1984 • 389 citations

Advances in Cyclic Nucleotide and Protein Phosphorylation Research

1975 • 373 citations

The inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. Subunit dissociation and guanine nucleotide-dependent hormonal inhibition.

1984 • 345 citations

Modification by islet-activating protein of receptor-mediated regulation of cyclic AMP accumulation in isolated rat heart cells.

1981 • 326 citations

Role of phosphatidylinositol turnover in alpha1 and of adenylate cyclase inhibition in alpha2 effects of catecholamines

1980 • 298 citations

Islet-activating protein. A modifier of receptor-mediated regulation of rat islet adenylate cyclase.

1981 • 257 citations

The A protomer of islet-activating protein, pertussis toxin, as an active peptide catalyzing ADP-ribosylation of a membrane protein

1983 • 215 citations

Isolation and properties of an NAD- and guanidine-dependent ADP-ribosyltransferase from turkey erythrocytes.

1980 • 199 citations

Stimulation by vasopressin and alpha-catecholamines of phosphatidylinositol formation in isolated rat liver parenchymal cells.

1980 • 188 citations

Islets-Activating Protein (IAP) in Bordetella pertussis that Potentiates Insulin Secretory Responses of Rats

1978 • 178 citations

Modulation by islet-activating protein of adenylate cyclase activity in C6 glioma cells.

1982 • 164 citations

Phosphatidylinositol metabolism in rat hepatocytes stimulated by vasopressin

1981 • 152 citations

Adrenergic control of glucose output and adenosine 3‘:5‘-monophosphate levels in hepatocytes from juvenile and adult rats.

1979 • 149 citations

Hepatic alpha 1-adrenergic receptors show agonist-specific regulation by guanine nucleotides. Loss of nucleotide effect after adrenalectomy.

1982 • 149 citations

alpha-Adrenergic activation of phosphorylase in liver cells involves mobilization of intracellular calcium without influx of extracellular calcium.

1982 • 143 citations

Characterization with [3H] dihydroergocryptine of the alpha-adrenergic receptor of the hepatic plasma membrane. Comparison with the beta-adrenergic receptor in normal and adrenalectomized rats

1978 • 136 citations

Differences between male and female rats in the regulation of hepatic glycogenolysis. The relative role of calcium and cAMP in phosphorylase activation by catecholamines.

1982 • 120 citations

Agonist versus antagonist binding to alpha-adrenergic receptors.

1980 • 118 citations

Biological Properties of Islets-Activating Protein (IAP) Purified from the Culture Medium of Bordetella pertussis

1978 • 117 citations

Acquisition of a beta-adrenergic response by adult rat hepatocytes during primary culture.

1983 • 117 citations

[3H]GDP release from rat and hamster adipocyte membranes independently linked to receptors involved in activation or inhibition of adenylate cyclase. Differential susceptibility to two bacterial toxins.

1984 • 116 citations

ADP-ribosylation of the Mr 83,000 stress-inducible and glucose-regulated protein in avian and mammalian cells: modulation by heat shock and glucose starvation.

1983 • 104 citations

ADP-ribosyltransferase activity in cultured hepatocytes. Interactions with DNA repair.

1982 • 101 citations

Changes in hormone responsiveness and cyclic AMP metabolism in rat hepatocytes during primary culture and effects of supplementing the medium with insulin and dexamethasone

1984 • 98 citations

Effects of adrenalectomy on hormone action on hepatic glucose metabolism. Reciprocal change in alpha- and beta-adrenergic activation of hepatic glycogen phosphorylase and calcium mobilization in adrenalectomized rats

1979 • 92 citations

ADP-ribosylation of nonhistone high mobility group proteins in intact cells.

1983 • 91 citations

Purification of rat liver phosphorylase kinase.

1982 • 90 citations

Hormonal activation of glycogen phosphorylase in hepatocytes from hypothyroid rats.

1978 • 86 citations

ADP-ribosylation in inner membrane of rat liver mitochondria.

1983 • 86 citations

Calcium Regulation in Biological Systems

1985 • 82 citations

Amino acid-specific ADP-ribosylation. Identification of an arginine-dependent ADP-ribosyltransferase in rat liver.

1981 • 81 citations

Modulation of the alpha 1-adrenergic control of hepatocyte calcium redistribution by increases in cyclic AMP.

1983 • 78 citations

Guanine nucleotide activation and inhibition of adenylate cyclase as modified by islet-activating protein, pertussis toxin, in mouse 3T3 fibroblasts

1983 • 73 citations

Conversion of adrenergic regulation of glycogen phosphorylase and synthase from an α to a β type during primary culture of rat hepatocytes

1982 • 71 citations

Thyroid membrane ADP ribosyltransferase activity. Stimulation by thyrotropin and activity in functioning and nonfunctioning rat thyroid cells in culture.

1981 • 66 citations

Adrenergic regulation of glycogenolysis in rat liver after cholestasis. Modulation of the balance between alpha 1 and beta 2 receptors.

1983 • 65 citations

Mechanism of action of choleragen andE. coli heat-labile enterotoxin: activation of adenylate cyclase by ADP-ribosylation

1981 • 61 citations

Subcellular distribution of mono(ADP-ribose) protein conjugates in rat liver

1981 • 44 citations

Acute Hormonal Regulation of Cyclic AMP Content and Glycogen Phosphorylase Activity in Fetal Liver in Organ Culture

1974 • 44 citations

Thyrotropin stimulation of the ADP-ribosyltransferase activity of bovine thyroid membranes.

1982 • 40 citations

Prevention by nicotinamide of desensitization to thyrotropin stimulation in cultured human thyroid cells.

1981 • 39 citations

ADP ribosylation of canine renal brush border membrane vesicle proteins is associated with decreased phosphate transport.

1982 • 39 citations

beta-Adrenergic receptors in rabbit liver plasma membranes. Predominance of beta 2-receptors and mediation of adrenergic regulation of hepatic glycogenolysis.

1983 • 38 citations

Altered hormone control of cyclic AMP formation in isolated parenchymal liver cells from rats treated with 2-acetylaminofluorene

1975 • 35 citations

NAD+-dependent ADP-ribosyltransferase in renal brush-border membranes

1983 • 34 citations

Hormonal Stimulation of Eucaryotic Cell ADP-ribosylation

1981 • 28 citations

Predominance of β-adrenergic over α-adrenergic receptor functions involved in phosphorylase activation in liver cells of cholestatic rats

1984 • 24 citations

Endogenous and cholera toxin-catalyzed ADP-ribosylation of a plasma membrane protein of RL-PR-C cloned rat hepatocytes

1981 • 23 citations

Isoproterenol-induced ADP-ribosylation of a single plasma membrane protein of cultured differentiated RL-PR-C hepatocytes

1981 • 19 citations

INSULIN RECEPTOR DOWN-REGULATION: PREVENTION AT A POST-RECEPTOR SITE

1981 • 18 citations

ADP‐Ribosylation of Membrane Proteins in Cholinergic Nerve Terminals

1982 • 16 citations

Mechanism of stimulation of ADP-ribosyltransferase in the renal brush-border membrane by EDTA

1984 • 6 citations

ADP-ribosyl-protein conjugate subclasses in various tissues. Specific influence of thyroid hormone on liver conjugates

1982 • 5 citations