Evidence for two distinct phosphorylation pathways activated by high affinity immunoglobulin E receptors.

The cytoplasmic domain of the T cell receptor ζ chain is sufficient to couple to receptor-associated signal transduction pathways

1991 • 782 citations

Monoclonal dinitrophenyl-specific murine IgE antibody: preparation, isolation, and characterization.

1980 • 653 citations

Increase of the Catalytic Activity of Phospholipase C-γ1 by Tyrosine Phosphorylation

1990 • 650 citations

Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor.

1990 • 647 citations

Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs

1990 • 629 citations

PDGF stimulation of inositol phospholipid hydrolysis requires PLC-γ1 phosphorylation on tyrosine residues 783 and 1254

1991 • 583 citations

Inhibition of tyrosine phosphorylation prevents T-cell receptor-mediated signal transduction.

1990 • 526 citations

Complete structure and expression in transfected cells of high affinity IgE receptor

1989 • 515 citations

Regulation of calcium influx by second messengers in rat mast cells

1988 • 506 citations

Engagement of the high-affinity IgE receptor activates src protein-related tyrosine kinases

1992 • 503 citations

T Cell Antigen Receptor-Mediated Activation of Phospholipase C Requires Tyrosine Phosphorylation

1990 • 476 citations

Association of B Cell Antigen Receptor with Protein Tyrosine Kinase Lyn

1991 • 471 citations

Tyrosine phosphatase CD45 is essential for coupling T-cell antigen receptor to the phosphatidyl inositol pathway

1990 • 466 citations

T cell antigen receptor activation pathways: The tyrosine kinase connection

1991 • 442 citations

The T cell receptor/CD3 complex is composed of at least two autonomous transduction modules

1992 • 438 citations

Anti-immunoglobulin stimulation of B lymphocytes activates src-related protein-tyrosine kinases.

1991 • 433 citations

Increases in tyrosine phosphorylation are detectable before phospholipase C activation after T cell receptor stimulation.

1990 • 432 citations

Activation of T Cells by a Tyrosine Kinase Activation Domain in the Cytoplasmic Tail of CD3 ε

1992 • 430 citations

The zeta chain is associated with a tyrosine kinase and upon T-cell antigen receptor stimulation associates with ZAP-70, a 70-kDa tyrosine phosphoprotein.

1991 • 415 citations

Co-association of CD3ζ with a receptor (CD16) for IgG Fc on human natural killer cells

1989 • 412 citations

Cellular immunity to HIV activated by CD4 fused to T cell or Fc receptor polypeptides

1991 • 391 citations

Functional activation of the T-cell antigen receptor induces tyrosine phosphorylation of phospholipase C-gamma 1.

1991 • 351 citations

Tyrosine phosphatase CD45 is required for T-cell antigen receptor and CD2-mediated activation of a protein tyrosine kinase and interleukin 2 production.

1991 • 349 citations

T-cell and basophil activation through the cytoplasmic tail of T-cell-receptor zeta family proteins.

1991 • 307 citations

Molecular Cloning of the Zeta Chain of the T Cell Antigen Receptor

1988 • 275 citations

Phosphorylation and dephosphorylation of the high-affinity receptor for immunoglobulin E immediately after receptor engagement and disengagement

1991 • 272 citations

Regulation of B Cell Antigen Receptor Signal Transduction and Phosphorylation by CD45

1991 • 269 citations

A macrophage Fcγ receptor and the mast cell receptor for IgE share an identical subunit

1989 • 268 citations

T Cell Activation Induces Rapid Tyrosine Phosphorylation of a Limited Number of Cellular Substrates

1989 • 258 citations

Family of disulphide-linked dimers containing the ζ and η chains of the T-cell receptor and the γ chain of Fc receptors

1990 • 249 citations

Tyrosine phosphorylation in T cells is regulated by phosphatase activity: studies with phenylarsine oxide.

1990 • 246 citations

Identification, purification, and characterization of a mast cell-associated cytolytic factor related to tumor necrosis factor.

1987 • 245 citations

Tyrosine phosphorylation coupled to IgE receptor-mediated signal transduction and histamine release.

1990 • 234 citations

A single amino acid in the glycosyl phosphatidylinositol attachment domain determines the membrane topology of FcγRIII

1989 • 189 citations

IgE-induced tyrosine phosphorylation of phospholipase C-gamma 1 in rat basophilic leukemia cells.

1991 • 184 citations

Fc gamma receptor type III (CD16) is included in the zeta NK receptor complex expressed by human natural killer cells.

1990 • 169 citations

Mechanisms for Regulating Expression of Membrane Isoforms of FcγRIII (CD16)

1989 • 162 citations

CD45. A prototype for transmembrane protein tyrosine phosphatases.

1991 • 142 citations

Quantitative relationships between aggregation of IgE receptors, generation of intracellular signals, and histamine secretion in rat basophilic leukemia (2H3) cells. Enhanced responses with heavy water.

1986 • 133 citations

Differential inhibition of T cell receptor signal transduction and early activation events by a selective inhibitor of protein-tyrosine kinase.

1990 • 106 citations

A combination of hydrogen peroxide and vanadate concomitantly stimulates protein tyrosine phosphorylation and polyphosphoinositide breakdown in different cell lines

1990 • 106 citations

Effect of vanadate on the cellular accumulation of pp15, an apparent product of insulin receptor tyrosine kinase action.

1988 • 103 citations

Studies with a monoclonal antibody to the β subunit of the receptor with high affinity for immunoglobulin E

1988 • 96 citations

Molecular cloning of the CD3 eta subunit identifies a CD3 zeta-related product in thymus-derived cells.

1990 • 92 citations

Sulfhydryl oxidation down-regulates T-cell signaling and inhibits tyrosine phosphorylation of phospholipase C gamma 1.

1992 • 88 citations

Insulin-stimulated Protein Tyrosine Phosphorylation in Intact Cells Evaluated by Giant Two-dimensional Gel Electrophoresis

1989 • 66 citations

Monoclonal antibodies to the leukocyte common antigen (CD45) inhibit IgE-mediated histamine release from human basophils.

1991 • 61 citations

Assessment of IgE-receptor function through measurement of hydrolysis of membrane inositol phospholipids. New insights on the phenomena of biphasic antigen concentration-response curves and desensitization.

1988 • 54 citations

Insulin-induced p21ras activation does not require protein kinase C, but a protein sensitive to phenylarsine oxide.

1991 • 51 citations

Phosphorylation of multiple CD3 zeta tyrosine residues leads to formation of pp21 in vitro and in vivo. Structural changes upon T cell receptor stimulation.

1992 • 50 citations

Tyrosine kinase-dependent phosphatidylinositol turnover and functional responses in the FcεR1 signalling pathway

1991 • 32 citations