The increased density of p38 mitogen-activated protein kinase-immunoreactive microglia in the sensorimotor cortex of aged TgCRND8 mice is associated predominantly with smaller dense-core amyloid plaques
Data up to Jan 2025
Total Citations Per Year
Abstract
References (52)
Resting Microglial Cells Are Highly Dynamic Surveillants of Brain Parenchyma in Vivo
2005 • 5,087 citations
ATP mediates rapid microglial response to local brain injury in vivo
2005 • 3,543 citations
Microglia: active sensor and versatile effector cells in the normal and pathologic brain
2007 • 3,382 citations
mouse brain in stereotaxic coordinates
1997 • 3,077 citations
Mitogen-activated protein kinases in apoptosis regulation
2004 • 1,403 citations
Bone Marrow-Derived Microglia Play a Critical Role in Restricting Senile Plaque Formation in Alzheimer's Disease
2006 • 1,191 citations
Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer disease.
1985 • 979 citations
Early-onset Amyloid Deposition and Cognitive Deficits in Transgenic Mice Expressing a Double Mutant Form of Amyloid Precursor Protein 695
2001 • 924 citations
Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease
2007 • 829 citations
p38 Mitogen-Activated Protein Kinase Is Activated after a Spinal Nerve Ligation in Spinal Cord Microglia and Dorsal Root Ganglion Neurons and Contributes to the Generation of Neuropathic Pain
2003 • 827 citations
Design-based stereology in neuroscience
2004 • 671 citations
Microglial response to amyloid plaques in APPsw transgenic mice.
1998 • 580 citations
Extracellular ATP or ADP Induce Chemotaxis of Cultured Microglia through Gi/o-Coupled P2Y Receptors
2001 • 549 citations
CD14 and Toll-Like Receptors 2 and 4 Are Required for Fibrillar Aβ-Stimulated Microglial Activation
2009 • 514 citations
Dynamics of the Microglial/Amyloid Interaction Indicate a Role in Plaque Maintenance
2008 • 474 citations
Trophic actions of extracellular nucleotides and nucleosides on glial and neuronal cells
1996 • 447 citations
Formation and maintenance of Alzheimer's disease β-amyloid plaques in the absence of microglia
2009 • 382 citations
p38 Kinase Is Activated in the Alzheimer's Disease Brain
1999 • 365 citations
Bone marrow stem cells have the ability to populate the entire central nervous system into fully differentiated parenchymal microglia
2004 • 345 citations
Requirement of p38 Mitogen-activated Protein Kinase for Neuronal Differentiation in PC12 Cells
1998 • 340 citations
Association of Microglia with Amyloid Plaques in Brains of APP23 Transgenic Mice
1999 • 332 citations
Complement C3 Deficiency Leads to Accelerated Amyloid Plaque Deposition and Neurodegeneration and Modulation of the Microglia/Macrophage Phenotype in Amyloid Precursor Protein Transgenic Mice
2008 • 293 citations
Activation of c-Jun N-Terminal Kinase and p38 in an Alzheimer's Disease Model Is Associated with Amyloid Deposition
2002 • 285 citations
Minocycline Alleviates Death of Oligodendrocytes by Inhibiting Pro-Nerve Growth Factor Production in Microglia after Spinal Cord Injury
2007 • 250 citations
Activation of Microglia Acidifies Lysosomes and Leads to Degradation of Alzheimer Amyloid Fibrils
2007 • 236 citations
Powerful beneficial effects of macrophage colony-stimulating factor on -amyloid deposition and cognitive impairment in Alzheimer's disease
2008 • 217 citations
Induction of Heme Oxygenase‐1 mRNA and Protein in Neocortex and Cerebral Vessels in Alzheimer's Disease
1995 • 209 citations
Aβ-Induced Inflammatory Processes in Microglia Cells of APP23 Transgenic Mice
2001 • 199 citations
Elementary Survey Sampling
2007 • 160 citations
MAPK-activated Protein Kinase 2 Deficiency in Microglia Inhibits Pro-inflammatory Mediator Release and Resultant Neurotoxicity
2006 • 158 citations
Localization of active forms of C-jun kinase (JNK) and p38 kinase in Alzheimer's disease brains at different stages of neurofibrillary degeneration
2001 • 158 citations
CTGF/Hcs24 induces chondrocyte differentiation through a p38 mitogen‐activated protein kinase (p38MAPK), and proliferation through a p44/42 MAPK/extracellular‐signal regulated kinase (ERK)
2001 • 157 citations
β-Amyloid precursor protein transgenic mice that harbor diffuse Aβ deposits but do not form plaques show increased ischemic vulnerability: Role of inflammation
2002 • 155 citations
Nuclear Localization of p38 MAPK in Response to DNA Damage
2009 • 144 citations
In vivo mapping of incremental cortical atrophy from incipient to overt Alzheimer’s disease
2009 • 128 citations
SPM-based count normalization provides excellent discrimination of mild Alzheimer's disease and amnestic mild cognitive impairment from healthy aging☆
2008 • 126 citations
Senile dementia of Alzheimer type: Astroglial reaction to extracellular neurofibrillary tangles in the hippocampus
1982 • 126 citations
The role and therapeutic potential of monocytic cells in Alzheimer's disease
2010 • 92 citations
Expression of stress‐activated kinases c‐Jun N‐terminal kinase (SAPK/JNK‐P) and p38 kinase (p38‐P), and tau hyperphosphorylation in neurites surrounding βA plaques in APP Tg2576 mice
2004 • 85 citations
Constitutive activity and differential localization of p38? and p38? MAPKs in adult mouse brain
2000 • 78 citations
Oxidative Stress and Neuronal Adaptation in Alzheimer Disease: The Role of SAPK Pathways
2003 • 65 citations
Abnormal processing of tau in the brain of aged TgCRND8 mice
2007 • 65 citations
ERK 1,2 and p38 pathways are involved in the proliferative stimuli mediated by urokinase in osteoblastic SaOS‐2 cell line
2001 • 58 citations
Morphologically distinct types of amyloid plaques point the way to a better understanding of Alzheimer’s disease pathogenesis
2010 • 56 citations
Application of triple immunohistochemistry to characterize amyloid plaque-associated inflammation in brains with Alzheimer's disease
2001 • 54 citations
Chronically increased oxidative stress in fibroblasts from Alzheimer's disease patients causes early senescence and renders resistance to apoptosis by oxidative stress
2005 • 49 citations
Role of p38 MAPK in the Regulation of Apoptosis Signaling Induced by TNF-α in Differentiated PC12 Cells
2002 • 48 citations
Serine 209 resides within a putative p38(MAPK) consensus motif and regulates monoamine oxidase‐A activity
2009 • 42 citations
Cell type-specific activation of p38 MAPK in the brain regions of hypoxic preconditioned mice
2007 • 40 citations
Differential activation of mitogen-activated protein kinase signalling pathways in the hippocampus of CRND8 transgenic mouse, a model of Alzheimer's disease
2008 • 37 citations
Complement receptor 3 (CD11b/CD18) is implicated in the elimination of β-amyloid peptides
2010 • 28 citations
Minocycline treatment prevents cavitation in rats after a cortical devascularizing lesion
2006 • 26 citations
Cited By (0)
No citing papers found in database