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Lipid activation of protein kinase C.

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Relation between various phospholipase actions on human red cell membranes and the interfacial phospholipid pressure in monolayers

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Protein kinase C is regulated in vivo by three functionally distinct phosphorylations

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Phorbol ester binding to protein kinase C requires a cysteine-rich zinc-finger-like sequence.

1989 • 439 citations

A comparative study of the phase transitions of phospholipid bilayers and monolayers

1979 • 393 citations

Green Fluorescent Protein (GFP)-tagged Cysteine-rich Domains from Protein Kinase C as Fluorescent Indicators for Diacylglycerol Signaling in Living Cells

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A simple method for the accurate determination of free [Ca] in Ca-EGTA solutions

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Local anesthetics and pressure: a comparison of dibucaine binding to lipid monolayers and bilayers

1987 • 272 citations

Protein kinase C contains two phorbol ester binding domains.

1991 • 234 citations

Reversible exposure of the pseudosubstrate domain of protein kinase C by phosphatidylserine and diacylglycerol.

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Phosphoinositide-specific phospholipase C-.delta.1 binds with high affinity to phospholipid vesicles containing phosphatidylinositol 4,5-bisphosphate

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NMR Structure of a Protein Kinase C-γ Phorbol-Binding Domain and Study of Protein−Lipid Micelle Interactions

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Phosphatidyl-L-serine Is Necessary for Protein Kinase C's High-Affinity Interaction with Diacylglycerol-Containing Membranes

1994 • 124 citations

Properties of membrane-inserted protein kinase C

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Ca²⁺-Signaling Cycle of a Membrane-Docking C2 Domain

1997 • 117 citations

Protein Kinase Cα Contains Two Activator Binding Sites That Bind Phorbol Esters and Diacylglycerols with Opposite Affinities

1996 • 114 citations

Mutagenesis of the C2 Domain of Protein Kinase C-α

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Differential irreversible insertion of protein kinase C into phospholipid vesicles by phorbol esters and related activators.

1992 • 101 citations

Mapping the Interfacial Binding Surface of Human Secretory Group IIa Phospholipase A₂

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A new kinetic approach for studying phospholipase C (Clostridium perfringens .alpha. toxin) activity on phospholipid monolayers

1988 • 88 citations

The regulatory region of protein kinase C gamma. Studies of phorbol ester binding to individual and combined functional segments expressed as glutathione S-transferase fusion proteins indicate a complex mechanism of regulation by phospholipids, phorbol esters, and divalent cations.

1994 • 84 citations

Differential Membrane-Binding and Activation Mechanisms of Protein Kinase C-α and -ε

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Regulation of Protein Kinase C βII by Its C2 Domain

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Lipid lateral heterogeneity in phosphatidylcholine/phosphatidylserine/diacylglycerol vesicles and its influence on protein kinase C activation

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Evidence for discrete diacylglycerol and phorbol ester activator sites on protein kinase C. Differences in effects of 1-alkanol inhibition, activation by phosphatidylethanolamine and calcium chelation.

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Association of protein kinase C with phospholipid monolayers: two-stage irreversible binding

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Activation of protein kinase C in lipid monolayers.

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Calcium-Independent Binding to Interfacial Phorbol Esters Causes Protein Kinase C To Associate with Membranes in the Absence of Acidic Lipids

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Binding Steps of Apolipoprotein A-I with Phospholipid Monolayers: Adsorption and Penetration

1998 • 48 citations

Membrane Penetration of Cytosolic Phospholipase A₂ Is Necessary for Its Interfacial Catalysis and Arachidonate Specificity

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Chemical specificity and physical properties of the lipid bilayer in the regulation of protein kinase C by anionic phospholipids: evidence for the lack of a specific binding site for phosphatidylserine.

1996 • 43 citations

Mechanism of the Apparent Cooperativity in the Interaction of Protein Kinase C with Phosphatidylserine

1998 • 37 citations

Molecular Modeling and Site-Directed Mutagenesis Studies of a Phorbol Ester-Binding Site in Protein Kinase C

1996 • 35 citations

Roles of Surface Hydrophobic Residues in the Interfacial Catalysis of Bovine Pancreatic Phospholipase A₂

1996 • 34 citations

A Phospholipase A2Kinetic and Binding Assay Using Phospholipid-Coated Hydrophobic Beads

1997 • 29 citations