Course of psychopathology, cognition and neurobiological abnormality in schizophrenia: developmental origins and amelioration by antipsychotics?

Implications of Normal Brain Development for the Pathogenesis of Schizophrenia

1987 • 3,683 citations

Smith's recognizable patterns of human malformation

1997 • 1,917 citations

Child developmental risk factors for adult schizophrenia in the British 1946 birth cohort

1994 • 1,326 citations

Neuropsychological Deficits in Neuroleptic Naive Patients With First-Episode Schizophrenia

1994 • 1,099 citations

Antecedents of Cerebral Palsy

1986 • 938 citations

Deficits in Small Interneurons in Prefrontal and Cingulate Cortices of Schizophrenic and Schizoaffective Patients

1991 • 889 citations

Duration of psychosis and outcome in first-episode schizophrenia

1992 • 878 citations

Epidemiology of Preterm Birth

1993 • 877 citations

Abnormally High Neuronal Density in the Schizophrenic Cortex

1995 • 866 citations

Is schizophrenia a neurodevelopmental disorder?

1987 • 838 citations

Neuroleptics and the Natural Course of Schizophrenia

1991 • 777 citations

Altered Distribution of Nicotinamide-Adenine Dinucleotide Phosphate—Diaphorase Cells in Frontal Lobe of Schizophrenics Implies Disturbances of Cortical Development

1993 • 660 citations

Schizophrenia susceptibility associated with interstitial deletions of chromosome 22q11.

1995 • 634 citations

From neuropathology to neurodevelopment

1995 • 569 citations

II. A Randomised Controlled Trial of Prophylactic Neuroleptic Treatment

1986 • 497 citations

Childhood antecedents of schizophrenia and affective illness: social adjustment at ages 7 and 11

1994 • 486 citations

Obstetric complications, neurodevelopmental deviance, and risk of schizophrenia

1987 • 471 citations

Neuromotor Precursors of Schizophrenia

1994 • 434 citations

Obstetric Complications and Schizophrenia: A Meta-Analysis

1995 • 404 citations

Neuropsychological Deficits in Schizophrenics

1994 • 387 citations

Brain morphology in first-episode schizophrenic-like psychotic patients: A quantitative magnetic resonance imaging study

1991 • 365 citations

Neuropsychological functioning of first-episode schizophreniform patients

1992 • 324 citations

Severity of symptoms in chronically institutionalized geriatric schizophrenic patients

1995 • 307 citations

Intellectual Deficits in First-Episode Schizophrenia: Evidence for Progressive Deterioration

1992 • 291 citations

The Positive-Negative Distinction in Schizophrenia

1992 • 268 citations

A prospective follow-up study of brain morphology and cognition in first-episode schizophrenic patients: Preliminary findings

1995 • 263 citations

Frontal and Temporal Lobe Brain Volumes in Schizophrenia

1995 • 242 citations

A combined analysis of D22S278 marker alleles in affected sib-pairs: Support for a susceptibility locus for schizophrenia at chromosome 22q12

1996 • 232 citations

Minor Physical Anomalies in Schizophrenia

1989 • 220 citations

Human fetal hippocampal development: I. Cytoarchitecture, myeloarchitecture, and neuronal morphologic features

1996 • 206 citations

Developmentally Moderated Expressions of the Neuropathology Underlying Schizophrenia

1994 • 203 citations

Chidhood precursors of psychiosis as clues to its evolutionary orgins

1995 • 200 citations

The anthropometric assessment of dysmorphic features in schizophrenia as an index of its developmental origins

1997 • 197 citations

Schizophrenia: developmental neuroscience and pathobiology

1993 • 196 citations

Course of Schizophrenia: Neuropsychological Evidence for a Static Encephalopathy

1993 • 187 citations

Risk of schizophrenia in adults born after obstetric complications and their association with early onset of illness: a controlled study.

1992 • 180 citations

Genetics, chance, and morphogenesis.

1987 • 172 citations

1H-magnetic resonance spectroscopy of the left temporal and frontal lobes in schizophrenia: Clinical, neurodevelopmental, and cognitive correlates

1994 • 155 citations

Course of treatment response in first-episode and chronic schizophrenia

1996 • 155 citations

Cognitive Dysfunction, Negative Symptoms, and Tardive Dyskinesia in Schizophrenia

1987 • 155 citations

Subtype Progression and Pathophysiologic Deterioration in Early Schizophrenia

1993 • 152 citations

The mortality and morbidity associated with umbilical cord prolapse

1995 • 141 citations

Familial, obstetric, and other clinical correlates of minor physical anomalies in schizophrenia

1991 • 139 citations

Is There Cognitive Decline in Schizophrenia?

1994 • 138 citations

Bilateral destruction of the fetal paraventricular nuclei prolongs gestation in sheep

1991 • 137 citations

Early childhood psychosis and bleeding during pregnancy

1975 • 135 citations

Brain anomalies in velo‐cardio‐facial syndrome

1994 • 133 citations

Monozygotic twins with chromosome 22q11 deletion and discordant phenotype.

1995 • 129 citations

Adverse infant outcomes associated with first-trimester vaginal bleeding.

1991 • 129 citations

Increased Rate of P300 Latency Prolongation With Age in Schizophrenia

1995 • 127 citations

Glial fibrillary acidic protein-immunoreactive astrocytosis in elderly patients with schizophrenia and dementia

1996 • 116 citations

Obstetric complications as antecedents of schizophrenia: Empirical effects of using different obstetric complication scales

1994 • 113 citations

Prospective clinicopathologic studies of schizophrenia: accrual and assessment of patients

1995 • 112 citations

Minor Physical Anomalies in Schizophrenia and Mood Disorders

1993 • 111 citations

Perinatal outcome of pregnancies complicated by vaginal bleeding

1992 • 108 citations

Psychopathology, executive (frontal) and general cognitive impairment in relation to duration of initially untreated versus subsequently treated psychosis in chronic schizophrenia

1997 • 108 citations

Sequential cross-sectional and 10-year prospective study of severe negative symptoms in relation to duration of initially untreated psychosis in chronic schizophrenia

1995 • 107 citations

The Natural Course of Schizophrenia and Effective Maintenance Drug Treatment

1986 • 101 citations

Dopamine D2 receptor density estimates in schizophrenia: A positron emission tomography study with11C-N-methylspiperone

1993 • 99 citations

The deficit state in first-episode schizophrenia

1994 • 98 citations

A population-based case-control study of risk factors for breech presentation

1996 • 97 citations

Premorbid adjustment as a predictor of phenomenological and neurobiological indices in schizophrenia

1995 • 94 citations

The relationship of minor physical anomalies and other putative indices of developmental disturbance in schizophrenia to abnormalities of cerebral structure on magnetic resonance imaging

1995 • 92 citations

The Palate and Down's Syndrome

1967 • 90 citations

Childhood behavioral precursors of adult symptom dimensions in schizophrenia

1995 • 89 citations

Psychotic features and the course of Alzheimer's disease: relationship to cognitive, electroencephalographic and computerized tomography findings

1993 • 87 citations

Deterioration in premorbid functioning in schizophrenia: a developmental model of negative symptoms in drug-free patients

1992 • 86 citations

The Longitudinal Stability of Cognitive Impairment in Schizophrenia

1995 • 86 citations

Recent Advances in Primary Palate and Midface Morphogenesis Research

1992 • 85 citations

Are Complications of Pregnancy and Birth Causes of Schizophrenia?

1988 • 81 citations

Cognitive dysfunction in chronic schizophrenia followed prospectively over 10 years and its longitudinal relationship to the emergence of tardive dyskinesia

1996 • 80 citations

Risk factors and infant outcomes associated with umbilical cord prolapse: A population-based case-control study among births in Washington State

1994 • 79 citations

Predictors of therapeutic response to haloperidol in acute schizophrenia.

1991 • 70 citations

The neurodevelopmental basis of schizophrenia

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Positive and negative symptoms/syndromes in schizophrenia: reliability and validity of different diagnostic systems

1995 • 63 citations

Cognitive dysfunction in schizophrenia followed up over 5 years, and its longitudinal relationship to the emergence of tardive dyskinesia

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DOES GROWTH RETARDATION PREDISPOSE THE FETUS TO CONGENITAL MALFORMATION?

1982 • 58 citations

Soft-Palate Myogenesis: A Developmental Field Paradigm

1993 • 58 citations

Computer reconstructions of human embryonic craniofacial morphology showing changes in relations between the face and brain during primary palate formation.

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Early Gastational Bleeding and Pregnancy Outcome: A Multivariable Analysis

1983 • 53 citations

Association between maternal bleeding during gestation and congenital anomalies in the offspring

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Predictors of human gestational length

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Two-hit model for sporadic congenital anomalies in mice with the disorganization mutation.

1993 • 46 citations

Limbic lobe embryology and anatomy: dissection and MR of the medial surface of the fetal cerebral hemisphere.

1995 • 46 citations

Link between pregnancy complications and minor physical anomalies in monozygotic twins discordant for schizophrenia

1994 • 43 citations

Symptom stability in geriatric chronic schizophrenic inpatients: A one-year follow-up study

1996 • 42 citations

MULTIPLE MINOR MALFORMATIONS AS A MARKER FOR PRENATAL ETIOLOGY OF CEREBRAL PALSY

1991 • 41 citations

Developmental trajectory and disease progression in schizophrenia: the conundrum, and insights from a 12-year prospective study in the Monaghan 101

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All out for chromosome six

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Minor congenital anomalies and ataxic cerebral palsy.

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Negative symptoms and the early course of schizophrenia

1992 • 31 citations

Low birth weight and preterm delivery in relation to early-gestation vaginal bleeding and elevated maternal serum alpha-fetoprotein.

1992 • 30 citations

The effect of hypothalamic lesions on the length of gestation in fetal sheep

1991 • 26 citations

Neurodevelopmental Significance of Minor and Major Congenital Anomalies in Neonatal High Risk Children

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Development of the basilar part of the occipital bone in normal human fetuses.

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The Neuroses of Development

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A twin study of palatal dimensions partitioning genetic and environmental contributions to variability.

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Minor congenital defects in children of low birth weight

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Executive (frontal) dysfunction and negative symptoms in schizophrenia: Apparent gender differences in ‘static’ v. ‘progressive’ profiles

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Primary hypoparathyroidism associated with ring chromosome 18

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The effect of hypothalamic lesions on the length of gestation in fetal sheep

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Birth Defects in Relation to Threatened Abortion

1994 • 5 citations

Age dependent change of ventricular measures in schizophrenia: Cross-sectional analysis

1994 • 4 citations

Cognitive decline in geriatric chronic schizophrenic patients: evidence for a neurodegenerative process?

1996 • 3 citations

Psychopathology and cognitive (executive) dysfunction in relation to duration of initially untreated psychosis in schizophrenia

1996 • 2 citations