Formation and Subsequent Repair of Alkylation Lesions in Tissues of Rodents Treated with Nitrosamines

[Organotropic carcinogenic effects of 65 various N-nitroso- compounds on BD rats].

1967 • 1,408 citations

Organotrope carcinogene Wirkungen bei 65 verschiedenen N-Nitroso-Verbindungen an BD-Ratten

1967 • 1,336 citations

A new pathway for DNA repair in Escherichia coli

1977 • 705 citations

Persistence of O 6-Ethylguanine in Rat-Brain DNA: Correlation with Nervous System-Specific Carcinogenesis by Ethylnitrosourea

1974 • 495 citations

XERODERMA PIGMENTOSUM: BIOCHEMICAL AND GENETIC CHARACTERISTICS

1975 • 406 citations

Nitrosamine-induced carcinogenesis. The alkylation of nucleic acids of the rat by N-methyl-N-nitrosourea, dimethylnitrosamine, dimethyl sulphate and methyl methanesulphonate

1968 • 378 citations

All oxygens in nucleic acids react with carcinogenic ethylating agents

1976 • 311 citations

Formation and Metabolism of Alkylated Nucleosides: Possible Role in Carcinogenesis by Nitroso Compounds and Alkylating Agents

1977 • 304 citations

Chemical carcinogenesis in the nervous system. Preferential accumulation of O6-methylguanine in rat brain deoxyribonucleic acid during repetitive administration of N-methyl-N-nitrosourea

1975 • 206 citations

Effect of dimethylnitrosamine on persistence of methylated guanines in rat liver and kidney DNA

1975 • 193 citations

Repair of O6-methylguanine in adapted Escherichia coli.

1978 • 180 citations

Nitrosamine-induced carcinogenesis. The alkylation of N-7 of guanine of nucleic acids of the rat by diethylnitrosamine, N-ethyl-N-nitrosourea and ethyl methanesulphonate

1971 • 140 citations

Formation and subsequent removal of O6-methylguanine from deoxyribonucleic acid in rat liver and kidney after small doses of dimethylnitrosamine

1978 • 105 citations

Increased excision of O6-methylguanine from rat liver DNA after chronic administration of dimethylnitrosamine.

1979 • 101 citations

Exhaustion and recovery of repair excision of O6-methylguanine from rat liver DNA

1976 • 100 citations

Effect of chronic treatment of rats with dimethylnitrosamine on the removal of O6-methylguanine from DNA.

1980 • 99 citations

Pathways of mutagenesis and repair in Escherichia coli exposed to low levels of simple alkylating agents

1978 • 95 citations

Alkylation of Rat Liver DNA by Dimethylnitrosamine: Effect of Dosage on O 6 -Methylguanine Levels 2

1977 • 93 citations

Enzymatic removal of O6-methylguanine from DNA by mammalian cell extracts

1978 • 83 citations

Chemical Carcinogens: How Dangerous Are Low Doses?

1978 • 77 citations

Dimethylnitrosamine inhibits enzymatic removal of O6-methylguanine from DNA

1978 • 62 citations

Formation and loss of alkylated purines from DNA of hamster liver after administration of dimethylnitrosamine.

1979 • 53 citations

Removal of methylated purines from rat liver DNA after administration of dimethylnitrosamine.

1978 • 40 citations

Mathematical Aspects of Dose-Response Studies in Carcinogenesis – The Concept of Thresholds

1976 • 40 citations

The absorption and metabolism in rats of small oral doses of dimethylnitrosamine. Implication for the possible hazard of dimethylnitrosamine in human food

1977 • 40 citations

DNA Repair Enzymes in Mammalian Cells

1977 • 36 citations

Dimethylnitrosamine formation in the gastro-intestinal tract of rats

1976 • 28 citations

Chemical Carcinogens in the Human Environment Problems and Quantitative Aspects

1976 • 24 citations

Endocrine factors as determinants of the susceptibility of the liver to carcinogenic agents.

1968 • 19 citations

Possible Mechanisms of Combination Effects in Chemical Carcinogenesis

1976 • 18 citations

Some Examples of Dose-Response Studies in Chemical Carcinogenesis

1976 • 17 citations

Effect of pretreatment with other dialkylnitrosamines on excision from hepatic DNA of O6-methylguanine produced by dimethylnitrosamine

1978 • 16 citations

Enhancement of hepatic and renal tumorigenesis in thyroidectomized NZR/Gd rats treated with dimethylnitrosamine

1976 • 13 citations

Effect of hypophysectomy on persistence of methylated purines in rat liver deoxyribonucleic acid after administration of dimethylnitrosamine

1978 • 9 citations

Some Aspects of the Metabolism of Dimethylnitrosamine in the Rat

1974 • 4 citations