Bacterial adaptation to oxidative stress: implications for pathogenesis and interaction with phagocytic cells

Superoxide Dismutase

1969 • 12,578 citations

The Biology of Oxygen Radicals

1978 • 3,361 citations

DNA Damage and Oxygen Radical Toxicity

1988 • 1,964 citations

Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli

1984 • 1,608 citations

Toxic DNA Damage by Hydrogen Peroxide Through the Fenton Reaction in Vivo and in Vitro

1988 • 1,505 citations

Biological effects of the superoxide radical

1986 • 1,446 citations

Positive control of a regulon for defenses against oxidative stress and some heat-shock proteins in Salmonella typhimurium

1985 • 1,025 citations

Superoxide dismutases

1989 • 953 citations

DNA REPAIR ENZYMES

1988 • 822 citations

Interaction of human defensins with Escherichia coli. Mechanism of bactericidal activity.

1989 • 695 citations

Synthesis of nitric oxide from <scp>l</scp>-arginine by neutrophils. Release and interaction with superoxide anion

1989 • 529 citations

Starvation-induced cross protection against heat or H2O2 challenge in Escherichia coli

1988 • 509 citations

Biological reactivity of hypochlorous acid: implications for microbicidal mechanisms of leukocyte myeloperoxidase.

1981 • 443 citations

DNA strand scission by enzymically generated oxygen radicals

1981 • 428 citations

Inducible repair of oxidative DNA damage in Escherichia coli

1983 • 415 citations

Endonuclease IV (nfo) mutant of Escherichia coli

1986 • 397 citations

Long-Lived Oxidants Generated by Human Neutrophils: Characterization and Bioactivity

1983 • 396 citations

Purification of the o-dianisidine peroxidase from Escherichia coli B. Physicochemical characterization and analysis of its dual catalatic and peroxidatic activities.

1979 • 371 citations

Manganese and Defenses against Oxygen Toxicity in Lactobacillus plantarum

1981 • 367 citations

Brominating Oxidants Generated by Human Eosinophils

1986 • 364 citations

An Alkyl Hydroperoxide Reductase from Salmonella typhimurium Involved in the Defense of DNA against Oxidative Damage

1989 • 337 citations

Catalase, superoxide dismutase, and virulence of Staphylococcus aureus. In vitro and in vivo studies with emphasis on staphylococcal--leukocyte interaction.

1975 • 324 citations

gamma Ray induced deoxyribonucleic acid strand breaks. 3' Glycolate termini.

1983 • 319 citations

Oxygen-dependent mutagenesis in Escherichia coli lacking superoxide dismutase.

1986 • 314 citations

The electron transport chain of the microbicidal oxidase of phagocytic cells and its involvement in the molecular pathology of chronic granulomatous disease.

1989 • 286 citations

Exonuclease III and endonuclease IV remove 3' blocks from DNA synthesis primers in H2O2-damaged Escherichia coli.

1986 • 270 citations

Mutagenicity of oxygen free radicals.

1982 • 270 citations

Enzymatic defenses against the toxicity of oxygen and of streptonigrin in Escherichia coli

1977 • 263 citations

Catalases HPI and HPII in Escherichia coli are induced independently

1985 • 246 citations

A global response induced in Escherichia coli by redox-cycling agents overlaps with that induced by peroxide stress

1989 • 240 citations

alpha, beta-Dihydroxyisovalerate dehydratase. A superoxide-sensitive enzyme.

1987 • 239 citations

Superoxide dismutase-rich bacteria. Paradoxical increase in oxidant toxicity.

1987 • 238 citations

Escherichia coli xth mutants are hypersensitive to hydrogen peroxide

1983 • 223 citations

Spontaneous mutagenesis and oxidative damage to DNA in Salmonella typhimurium.

1987 • 222 citations

Singlet oxygen production by human eosinophils.

1988 • 207 citations

Endonuclease III (nth) mutants of Escherichia coli.

1985 • 196 citations

Singlet Excited Oxygen as a Mediator of the Antibacterial Action of Leukocytes

1974 • 190 citations

Endonuclease IV of Escherichia coli is induced by paraquat.

1987 • 188 citations

Genetic mapping of katF, a locus that with katE affects the synthesis of a second catalase species in Escherichia coli

1984 • 187 citations

Homogeneous Escherichia coli endonuclease IV. Characterization of an enzyme that recognizes oxidative damage in DNA.

1988 • 183 citations

THE ROLE OF OXYGEN AND ITS DERIVATIVES IN MICROBIAL PATHOGENESIS AND HOST DEFENSE

1984 • 179 citations

Biosynthesis and regulation of superoxide dismutases

1988 • 178 citations

A new mechanism for repairing oxidative damage to DNA: (A)BC excinuclease removes AP sites and thymine glycols from DNA

1989 • 177 citations

Induction of superoxide dismutase in Escherichia coli by heat shock.

1987 • 173 citations

Isolation of catalase-deficient Escherichia coli mutants and genetic mapping of katE, a locus that affects catalase activity

1984 • 165 citations

Exonuclease III and the catalase hydroperoxidase II in Escherichia coli are both regulated by the katF gene product.

1989 • 159 citations

The 65kDa antigen of mycobacteria—a common bacterial protein?

1987 • 154 citations

Transcriptional and posttranscriptional regulation of manganese superoxide dismutase biosynthesis in Escherichia coli, studied with operon and protein fusions

1988 • 139 citations

Human Neutrophil Antimicrobial Activity

1988 • 133 citations

Regulation of the synthesis of catalase and peroxidase in Escherichia coli.

1978 • 132 citations

Overproduction of peroxide-scavenging enzymes in Escherichia coli suppresses spontaneous mutagenesis and sensitivity to redox-cycling agents in oxyR-mutants.

1988 • 128 citations

Induction and repression of outer membrane proteins by anaerobic growth of Neisseria gonorrhoeae

1987 • 127 citations

Escherichia coli proteins inducible by oxidative stress mediated by the superoxide radical

1989 • 118 citations

Separation of sublethal and lethal effects of the bactericidal/permeability increasing protein on Escherichia coli.

1990 • 118 citations

Purification and characterization of hydroperoxidase II of Escherichia coli B.

1979 • 112 citations

Inactivation of enzymes and oxidative modification of proteins by stimulated neutrophils

1987 • 111 citations

Myeloperoxidase as an effective inhibitor of hydroxyl radical production. Implications for the oxidative reactions of neutrophils.

1986 • 109 citations

Stimulated human neutrophils limit iron-catalyzed hydroxyl radical formation as detected by spin-trapping techniques.

1986 • 108 citations

Molecular genetics of superoxide dismutases

1988 • 107 citations

Anaerobic biosynthesis of the manganese-containing superoxide dismutase in Escherichia coli.

1984 • 98 citations

Superoxide Dismutase from Mycobacterium tuberculosis

1976 • 96 citations

Role for Endogenous and Acquired Peroxidase in the Toxoplasmacidal Activity of Murine and Human Mononuclear Phagocytes

1982 • 93 citations

Purification and properties of a unique superoxide dismutase from Nocardia asteroides.

1983 • 92 citations

Effects of oxygen stress on membrane functions in Escherichia coli: role of HPI catalase

1988 • 86 citations

DNA damage by superoxide-generating systems in relation to the mechanism of action of the anti-tumour antibiotic adriamycin

1983 • 84 citations

Iron mediates paraquat toxicity in Escherichia coli.

1986 • 83 citations

Relationship between superoxide dismutase and pathogenic mechanisms of Listeria monocytogenes

1979 • 82 citations

Superoxide radicals and phagocytosis

1974 • 81 citations

Oxygen toxicity in Streptococcus sanguis. The relative importance of superoxide and hydroxyl radicals.

1982 • 74 citations

Neutrophil degranulation inhibits potential hydroxyl-radical formation. Relative impact of myeloperoxidase and lactoferrin release on hydroxyl-radical production by iron-supplemented neutrophils assessed by spin-trapping techniques

1989 • 71 citations

Induction of superoxide dismutases in Escherichia coli B by metal chelators

1985 • 67 citations

Heat shock inhibits NADPH oxidase in human neutrophils

1988 • 63 citations

Do humans neutrophils form hydroxyl radical? Evaluation of an unresolved controversy

1988 • 60 citations

Phagocyte-derived lactate stimulates oxygen consumption by Neisseria gonorrhoeae. An unrecognized aspect of the oxygen metabolism of phagocytosis.

1988 • 60 citations

Mutagenic activity of chloramines

1987 • 59 citations

Purification and characterization of the major iron-regulated protein expressed by pathogenic Neisseriae.

1987 • 57 citations

Increased superoxide radical production evokes inducible DNA repair in Escherichia coli.

1985 • 55 citations

Intracellular localization of the superoxide dismutases of Escherichia coli: a reevaluation

1977 • 55 citations

Isolation of gene fusions (soi::lacZ) inducible by oxidative stress in Escherichia coli.

1988 • 53 citations

The Intracellular Survival and Growth of Gonococci in Human Phagocytes

1979 • 50 citations

Compartmentalization of catalases in Escherichia coli

1988 • 47 citations

Cloning of the exonuclease III gene of Escherichia coli

1980 • 46 citations

Absence of superoxide dismutase in some strains of Neisseria gonorrhoeae

1979 • 45 citations

Role of extracellular iron in the action of the quinone antibiotic streptonigrin: mechanisms of killing and resistance of Neisseria gonorrhoeae

1987 • 38 citations

Formation of endonuclease III-sensitive sites as a consequence of oxygen radical attack on DNA

1989 • 37 citations

Loss of catalase activity in Tn1545-induced mutants does not reduce growth of Listeria monocytogenes in vivo

1989 • 36 citations

Bacterial iron enhances oxygen radical-mediated killing of Staphylococcus aureus by phagocytes

1990 • 36 citations

Myeloperoxidase-mediated damage to the succinate oxidase system of Escherichia coli. Evidence for selective inactivation of the dehydrogenase component.

1987 • 34 citations

Effect of human polymorphonuclear and mononuclear leukocytes on chromosomal and plasmid DNA of Escherichia coli. Role of acid DNase.

1984 • 30 citations

Oxidant stress in Neisseria gonorrhoeae: adaptation and effects on L-(+)-lactate dehydrogenase activity

1989 • 28 citations

Cytoplasmic membrane is the target organelle for transition metal mediated damage induced by paraquat in Escherichia coli

1988 • 26 citations

Induction of the manganese-containing superoxide dismutase in Escherichia coli is independent of the oxidative stress (oxyR-controlled) regulon.

1988 • 17 citations

An electron spin resonance study of oxyradical generation in superoxide dismutase- and catalase-deficient mutants of Escherichia coli K-12

1989 • 13 citations

The Role of Hydroxyl Radical in Chromosomal and Plasmid Damage inNeisseria Gonorrhoeae in vivo

1989 • 9 citations

Fate of the DNA in plasmid-containing Escherichia coli minicells ingested by human neutrophils

1987 • 6 citations