Molecular genetics of superoxide dismutases

Superoxide Dismutase

1969 • 12,578 citations

Oxygen toxicity, oxygen radicals, transition metals and disease

1984 • 5,301 citations

The Biology of Oxygen Radicals

1978 • 3,361 citations

Dietary Carcinogens and Anticarcinogens

1983 • 3,028 citations

Superoxide Dismutases

1975 • 1,673 citations

Superoxide Radical: An Endogenous Toxicant

1983 • 1,176 citations

Positive control of a regulon for defenses against oxidative stress and some heat-shock proteins in Salmonella typhimurium

1985 • 1,025 citations

Mitochondrial Superoxide Dismutase

1973 • 965 citations

Aspects of the Structure, Function, and Applications of Superoxide Dismutas

1987 • 859 citations

Isolation of superoxide dismutase mutants in Escherichia coli: is superoxide dismutase necessary for aerobic life?

1986 • 777 citations

Superoxide and Superoxide Dismutases

1978 • 754 citations

Superoxide and superoxide dismutases

1993 • 518 citations

Transgenic mice with increased Cu/Zn-superoxide dismutase activity: animal model of dosage effects in Down syndrome.

1987 • 461 citations

Overproduction of human Cu/Zn-superoxide dismutase in transfected cells: extenuation of paraquat-mediated cytotoxicity and enhancement of lipid peroxidation.

1986 • 322 citations

Oxygen-dependent mutagenesis in Escherichia coli lacking superoxide dismutase.

1986 • 314 citations

Superoxide radical and the oxygen enhancement of the toxicity of paraquat in Escherichia coli.

1978 • 298 citations

A yeast mutant lacking mitochondrial manganese-superoxide dismutase is hypersensitive to oxygen.

1986 • 262 citations

Architecture and anatomy of the chromosomal locus in human chromosome 21 encoding the Cu/Zn superoxide dismutase.

1985 • 251 citations

Biochemical mechanisms accounting for the toxic action of oxygen on living organisms: The key role of superoxide dismutase

1978 • 249 citations

Isolation and sequence of complementary DNA encoding human extracellular superoxide dismutase.

1987 • 239 citations

Superoxide dismutase-rich bacteria. Paradoxical increase in oxidant toxicity.

1987 • 238 citations

Superoxide dismutase, glutathione peroxidase and lipoperoxidation in Oown's syndrome fetal brain

1984 • 224 citations

Superoxide mediates the toxicity of paraquat for cultured mammalian cells.

1988 • 197 citations

Is hydroxyl radical generated by the Fenton reaction in vivo?

1985 • 173 citations

Superoxide and superoxide dismutase in chemistry, biology and medicine

1987 • 158 citations

A Streptococcus mutans superoxide dismutase that is active with either manganese or iron as a cofactor.

1986 • 150 citations

Human Cu/Zn superoxide dismutase cDNA: isolation of clones synthesising high levels of active or inactive enzyme from an expression library

1985 • 149 citations

The copper, zinc-superoxide dismutase gene of Saccharomyces cerevisiae: cloning, sequencing, and biological activity.

1988 • 147 citations

SUPEROXIDE RADICALS, SUPEROXIDE DISMUTASES AND THE AEROBIC LIFESTYLE

1978 • 140 citations

Superoxide dismutase and the oxygen enhancement of radiation lethality

1976 • 140 citations

Transcriptional and posttranscriptional regulation of manganese superoxide dismutase biosynthesis in Escherichia coli, studied with operon and protein fusions

1988 • 139 citations

Iron superoxide dismutase. Nucleotide sequence of the gene from Escherichia coli K12 and correlations with crystal structures.

1988 • 138 citations

Pathology of Oxygen Toxicity

1983 • 136 citations

Pathology of oxygen toxicity

1982 • 136 citations

Nucleotide sequence analysis of the nuclear gene coding for manganese superoxide dismutase of yeast mitochondria, a gene previously assumed to code for the Rieske iron‐sulphur protein

1985 • 129 citations

Cloning and mapping of the manganese superoxide dismutase gene (sodA) of Escherichia coli K-12

1983 • 123 citations

Structure and gene expression of theE. coliMn-superoxide dismutase gene

1986 • 116 citations

Localization of manganese superoxide dismutase in peroxisomes isolated from Pisum sativum L.

1987 • 115 citations

Bacteriocuprein superoxide dismutases in pseudomonads

1985 • 115 citations

Examination of the role of arginine-143 in the human copper and zinc superoxide dismutase by site-specific mutagenesis.

1987 • 104 citations

Nucleotide sequences of cDNAs coding for rat manganese-containing superoxide dismutase

1987 • 104 citations

Effect of Hyperbaric Oxygen on Microorganisms

1971 • 101 citations

Copper-zinc superoxide dismutase from Caulobacter crescentus CB15. A novel bacteriocuprein form of the enzyme.

1982 • 98 citations

Expression of transfected human CuZn superoxide dismutase gene in mouse L cells and NS20Y neuroblastoma cells induces enhancement of glutathione peroxidase activity

1988 • 96 citations

Amino Terminal Acetylation of Authentic Human Cu,Zn Superoxide Dismutase Produced in Yeast

1987 • 96 citations

Cloning of cDNA for maize superoxide dismutase 2 (SOD2).

1987 • 92 citations

Biosynthesis of mitochondrial manganese superoxide dismutase in saccharomyces cerevisiae. Precursor form of mitochondrial superoxide dismutase made in the cytoplasm.

1982 • 88 citations

Human copper-zinc superoxide dismutase complements superoxide dismutase-deficient Escherichia coli mutants.

1987 • 81 citations

Superoxide dismutase. Reversible removal of manganese and its substitution by cobalt, nickel or zinc.

1976 • 75 citations

Some characteristics of hyperoxia-adapted HeLa cells. A tissue culture model for cellular oxygen tolerance.

1985 • 70 citations

The presence of a copper/zinc superoxide dismutase in the bacterium Photobacterium leiognathi: a likely case of gene transfer from eukaryotes to prokaryotes.

1985 • 70 citations

Isolation and reconstitution of iron- and manganese-containing superoxide dismutases from Bacteroides thetaiotaomicron

1986 • 66 citations

Scientific basis for the clinical use of superoxide dismutase

1986 • 66 citations

Cloning of the iron superoxide dismutase gene (sodB) in Escherichia coli K-12

1984 • 65 citations

Characterization of the O2-induced manganese-containing superoxide dismutase from Bacteroides fragilis

1985 • 65 citations

High-level expression of enzymatically active human Cu/Zn superoxide dismutase in Escherichia coli.

1986 • 65 citations

Lipid Peroxidation and Superoxide Dismutase-1 and Glutathione Peroxidase Activities in Trisomy 16 Fetal Mice and Human Trisomy 21 Fibroblasts

1987 • 64 citations

Bacteriocuprein superoxide dismutase of Photobacterium leiognathi. Isolation and sequence of the gene and evidence for a precursor form.

1987 • 62 citations

The Primary Structure of Cu-Zn Superoxide Dismutase fromPhotobacterium leiognathi:Evidence for a Separate Evolution of Cu-Zn Superoxide Dismutase in Bacteria

1983 • 61 citations

Targeting efficiency of a mitochondrial pre-sequence is dependent on the passenger protein.

1986 • 60 citations

Human Cu/Zn superoxide dismutase gene: molecular characterization of its two mRNA species

1984 • 58 citations

Down syndrome with duplication of a region of chromosome 21 containing the CuZn superoxide dismutase gene without detectable karyotypic abnormality

1987 • 57 citations

Selective oxidation of the exonuclease domain of bacteriophage T7 DNA polymerase.

1987 • 56 citations

Paraquat-mediated selection for mutations in the manganese-superoxide dismutase gene sodA

1986 • 55 citations

Intracellular localization of the superoxide dismutases of Escherichia coli: a reevaluation

1977 • 55 citations

Cloning and sequencing of a rat CuZn superoxide dismutase cDNA. Correlation between CuZn superoxide dismutase mRNA level and enzyme activity in rat and mouse tissues

1987 • 55 citations

The function of superoxide dismutase during the enzymatic formation of the free radical of ribonucleotide reductase.

1987 • 54 citations

Crystallographic characterization of recombinant human CuZn superoxide dismutase.

1986 • 53 citations

Superoxide dismutase deficiency and the toxicity of the products of autooxidation of polyunsaturated fatty acids in yeast

1989 • 52 citations

Characterization of an oxygen-tolerant cell line derived from Chinese hamster ovary

1985 • 52 citations

CYTOGENETIC ANALYSIS OF THE cSOD MICROREGION IN DROSOPHILA MELANOGASTER

1986 • 48 citations

Submicroscopic duplication of chromosome 21 and trisomy 21 phenotype (Down syndrome)

1987 • 36 citations

Isolation and characterization of a protein with cyanide-sensitive superoxide dismutase activity from the prokaryote, paracoccus denitrificans

1982 • 32 citations

Chemical aspects of structure, function and evolution of superoxide dismutases

1983 • 30 citations

In vitro synthesis, importation and processing of Mn-superoxide dismutase (SOD-3) into maize mitochondria

1987 • 29 citations

Copper/Zinc superoxide dismutase: How likely is gene transfer from ponyfish toPhotobacterium leiognathi?

1986 • 29 citations

Human Cu/Zn superoxide dismutase gene family: molecular structure and characterization of four Cu/Zn superoxide dismutase-related pseudogenes.

1986 • 27 citations

Mutations in Escherichia coli that effect sensitivity to oxygen

1987 • 25 citations

Chemical aspects of the structure, function and evolution of superoxide dismutases

1984 • 24 citations

The sequence of the Cu–Zn superoxide dismutase gene ofDrosophila

1987 • 23 citations

Oxidation increases the proteolytic susceptibility of a localized region in rhodanese.

1987 • 20 citations

Effect of normobaric hyperoxia on antioxidant defenses of hela and CHO cells

1988 • 18 citations

Lack of cross-resistance to X-irradiation in oxygen-resistant mammalian cell lines

1985 • 12 citations

Superoxide‐induced deimination of arginine in hematopoietic cells

1988 • 11 citations

First Description of a Variant of E.Coli Lacking Superoxide Dismutase Activity Yet Able to Grow Efficiently on Minimal, Oxygenated Medium

1988 • 10 citations

Superoxide dismutase in Drosophila melanogaster

1985 • 9 citations

Drosophila Cu-Zn superoxide dismutase cDNA sequence

1987 • 9 citations

Cell‐free synthesis of human Cu/Zn‐superoxide dismutase

1980 • 8 citations