Do humans neutrophils form hydroxyl radical? Evaluation of an unresolved controversy

Oxygen toxicity, oxygen radicals, transition metals and disease

1984 • 5,301 citations

The catalytic decomposition of hydrogen peroxide by iron salts

1934 • 2,483 citations

Oxygen free radicals and iron in relation to biology and medicine: Some problems and concepts

1986 • 2,052 citations

Biological effects of the superoxide radical

1986 • 1,446 citations

Superoxide radical inhibits catalase.

1982 • 1,274 citations

The respiratory burst of phagocytes.

1984 • 914 citations

Spin trapping of superoxide and hydroxyl radical: Practical aspects

1980 • 861 citations

Formation of a thiobarbituric‐acid‐reactive substance from deoxyribose in the presence of iron salts

1981 • 830 citations

Spin trapping

1971 • 829 citations

A Mechanism for the Production of Ethylene from Methional

1970 • 668 citations

Inhibition of the iron-catalysed formation of hydroxyl radicals from superoxide and of lipid peroxidation by desferrioxamine

1979 • 637 citations

H2O2 Release from Human Granulocytes during Phagocytosis

1977 • 586 citations

The requirement for iron (III) in the initiation of lipid peroxidation by iron (II) and hydrogen peroxide.

1987 • 547 citations

Role of Iron in Bacterial Infection

1978 • 493 citations

The thiobarbituric acid reagent as a test for the oxidation of unsaturated fatty acids by various agents.

1949 • 487 citations

CHARACTERIZATION OF THE RED PIGMENT FORMED IN THE 2‐THIOBARBITURIC ACID DETERMINATION OF OXIDATIVE RANCIDITY^a,b

1958 • 403 citations

Long-Lived Oxidants Generated by Human Neutrophils: Characterization and Bioactivity

1983 • 396 citations

Iron mobilization from ferritin by superoxide derived from stimulated polymorphonuclear leukocytes. Possible mechanism in inflammation diseases.

1984 • 392 citations

Aromatic hydroxylation as a potential measure of hydroxyl-radical formation in vivo. Identification of hydroxylated derivatives of salicylate in human body fluids

1986 • 374 citations

Evidence for role of hydroxyl radical in complement and neutrophil-dependent tissue injury.

1983 • 338 citations

Lactoferrin enhances hydroxyl radical production by human neutrophils, neutrophil particulate fractions, and an enzymatic generating system.

1981 • 338 citations

THE INVOLVEMENT OF LACTOFERRIN IN THE HYPOSIDEREMIA OF ACUTE INFLAMMATION

1974 • 294 citations

Site-directed mutagenesis

1986 • 286 citations

Generation of Hydroxyl Radical by Enzymes, Chemicals, and Human Phagocytes In Vitro

1979 • 280 citations

Hydrogen peroxide kills Staphylococcus aureus by reacting with staphylococcal iron to form hydroxyl radical.

1981 • 280 citations

Hemoglobin potentiates central nervous system damage.

1987 • 262 citations

The Microbicidal Mechanisms of Human Neutrophils and Eosinophils

1981 • 259 citations

Evidence for hydroxyl radical production by human neutrophils.

1977 • 257 citations

Superoxide-dependent and ascorbate-dependent formation of hydroxyl radicals from hydrogen peroxide in the presence of iron. Are lactoferrin and transferrin promoters of hydroxyl-radical generation?

1987 • 253 citations

Lipid peroxidation: its measurement, occurrence, and significance in animal tissues.

1967 • 250 citations

Unusual copper-induced sensitization of the biological damage due to superoxide radicals.

1981 • 240 citations

Role of myeloperoxidase-mediated antimicrobial systems in intact leukocytes.

1972 • 236 citations

Ozonation of Water: Role of Hydroxyl Radicals as Oxidizing Intermediates

1975 • 197 citations

Polymorphonuclear leukocyte-mediated cell and tissue injury: Oxygen metabolites and their relations to human disease

1985 • 197 citations

Human granulocyte generation of hydroxyl radical.

1978 • 191 citations

Lactoferrin Deficiency Associated with Altered Granulocyte Function

1982 • 172 citations

Do human neutrophils make hydroxyl radical? Determination of free radicals generated by human neutrophils activated with a soluble or particulate stimulus using electron paramagnetic resonance spectrometry.

1986 • 171 citations

The production of hydroxyl and superoxide radicals by stimulated human neutrophils — measurements by EPR spectroscopy

1979 • 161 citations

Hydroxyl radical generation by polymorphonuclear leukocytes measured by electron spin resonance spectroscopy.

1979 • 156 citations

Ethylene formation from methional

1978 • 156 citations

The effect of human serum transferrin and milk lactoferrin on hydroxyl radical formation from superoxide and hydrogen peroxide.

1984 • 147 citations

Superoxide and superoxide dismutase in chemistry, biology and medicine

1987 • 141 citations

The ability of scavengers to distinguish OH· production in the iron-catalyzed Haber-Weiss reaction: Comparison of four assays for OH·

1987 • 138 citations

Ethylene formation by polymorphonuclear leukocytes. Role of myeloperoxidase.

1978 • 121 citations

Spin trapping of the azidyl radical in azide/catalase/H2O2 and various azide/peroxidase/H2O2 peroxidizing systems.

1985 • 117 citations

Myeloperoxidase as an effective inhibitor of hydroxyl radical production. Implications for the oxidative reactions of neutrophils.

1986 • 109 citations

Stimulated human neutrophils limit iron-catalyzed hydroxyl radical formation as detected by spin-trapping techniques.

1986 • 108 citations

Detection of the Production of Oxygen-Centered Free Radicals by Human Neutrophils Using Spin Trapping Techniques: A Critical Perspective

1987 • 106 citations

Fate of human lactoferrin and myeloperoxidase in phagocytizing human neutrophils: effects of immunoglobulin G subclasses and immune complexes coated on latex beads

1975 • 105 citations

Use of spin traps in biological systems

1985 • 102 citations

Oxidation of salicylates by stimulated granulocytes: evidence that these drugs act as free radical scavengers in biological systems.

1987 • 98 citations

Lactoferrin-catalysed hydroxyl radical production. Additional requirement for a chelating agent

1983 • 96 citations

Enhanced production of hydroxyl radicals by the xanthine-xanthine oxidase reaction in the presence of lactoferrin

1982 • 90 citations

Chemical Evidence for Production of Hydroxyl Radicals During Microsomal Electron Transfer

1979 • 90 citations

A new method for the detection of hydroxyl radical production by phagocytic cells

1980 • 89 citations

Comparison of human lactoferrins from milk and neutrophilic leucocytes. Relative molecular mass, isoelectric point, iron-binding properties and uptake by the liver

1985 • 85 citations

Oxygen radical-induced erythrocyte hemolysis by neutrophils. Critical role of iron and lactoferrin.

1985 • 75 citations

Prooxidant action of desferrioxamine: Fenton-like production of hydroxyl radicals by reduced ferrioxamine

1986 • 71 citations

Hydrogen peroxide causes dimethylthiourea consumption while hydroxyl radical causes dimethyl sulfoxide consumption in vitro

1985 • 59 citations

Role of free radical processes in stimulated human polymorphonuclear leukocytes

1986 • 51 citations

Oxidative decarboxylation of benzoate to carbon dioxide by rat liver microsomes: a probe for oxygen radical production during microsomal electron transfer

1982 • 48 citations

Myeloperoxidase oxidation of sulfur‐centered and benzoic acid hydroxyl radical scavengers

1985 • 40 citations

The interaction of hydroxyl radicals with dimethylsulfoxide produces formaldehyde

1980 • 39 citations

Evidence for production of oxidizing radicals by the particulate O-2- forming system from human neutrophils

1979 • 37 citations

Detection of phagocyte-derived free radicals with spin trapping techniques: Effect of temperature and cellular metabolism

1988 • 34 citations

Bactericidal capacity of phorbol myristate acetate-treated human polymorphonuclear leukocytes

1978 • 33 citations

Oxygen‐derived radicals from Trypanosoma cruzi‐stimulated human neutrophils

1983 • 31 citations

Iodination catalyzed by the xanthine oxidase system: role of hydroxyl radicals

1982 • 30 citations

Putative superoxide dismutase activity of iron-EDTA: A reexamination

1980 • 29 citations

The production of oxygen‐derived radicals by neutrophils from selenium‐deficient cattle

1981 • 29 citations

Effect of staphylococcal iron content on the killing of Staphylococcus aureus by polymorphonuclear leukocytes

1981 • 27 citations

Evidence that OH· production by human PMNs is related to prostaglandin metabolism

1980 • 25 citations

Heterogeneous Pathways of Oxidizing Radical Production in Human Neutrophils and the HL-60 Cell Line

1982 • 19 citations

Determination of Alternate Pathway Complement Kinetics by Electron Spin Resonance Spectroscopy

1983 • 18 citations

Metabolism of benzoic acid by stimulated polymorphonuclear cells

1986 • 16 citations