Use of pH studies to elucidate the catalytic mechanism of rabbit muscle creatine kinase

[6] Statistical analysis of enzyme kinetic data

1979 • 2,002 citations

Proton Transfer, Acid‐Base Catalysis, and Enzymatic Hydrolysis. Part I: ELEMENTARY PROCESSES

1964 • 1,743 citations

ADENOSINETRIPHOSPHATE-CREATINE TRANSPHOSPHORYLASE

1954 • 396 citations

Determining the Chemical Mechanisms of Enzyme‐Catalyzed Reactions by Kinetic Studies

1977 • 340 citations

The mechanism of the reaction catalysed by adenosine triphosphate-creatine phosphotransferase

1965 • 286 citations

Essential arginyl residue at the nucleotide binding site of creatine kinase

1975 • 196 citations

pK of the lysine amino group at the active site of acetoacetate decarboxylase

1971 • 195 citations

Inhibition of adenosine 5′-triphosphate–creatine phosphotransferase by substrate–anion complexes. Evidence for the transition-state organization of the catalytic site

1971 • 191 citations

Isotope Exchange Studies of the Mechanism of the Reaction Catalyzed by Adenosine Triphosphate: Creatine Phosphotransferase

1966 • 176 citations

Determination of the Rate of Hexokinase-Glucose Dissociation by the Isotope-trapping Method

1974 • 142 citations

Structural Changes Induced by Substrates and Anions at the Active Site of Creatine Kinase

1972 • 134 citations

A refined model of the sugar binding site of yeast hexokinase B

1978 • 130 citations

Specificity of creatine kinase. New glycocyamines and glycocyamine analogs related to creatine

1971 • 128 citations

Investigations of substrate specificity and reaction mechanism of several kinases using chromium(III) adenosine 5'-triphosphate and chromium(III) adenosine 5'-diphosphate

1980 • 112 citations

High resolution crystal structures of yeast hexokinase complexes with substrates, activators, and inhibitors. Evidence for an allosteric control site.

1977 • 103 citations

Site actif des ATP: Guanidine phosphotransférases

1968 • 94 citations

Inhibition of Creatine Kinase by Chromium Nucleotides

1973 • 91 citations

A study of the ‘reactive’ sulphydryl groups of adenosine 5′-triphosphate-creatine phosphotransferase

1962 • 81 citations

Nonessentiality of the Active Sulfhydryl Group of Rabbit Muscle Creatine Kinase

1974 • 81 citations

The Role of the Lysyl Residue at the Active Site of Creatine Kinase

1974 • 76 citations

Identification of the six ligands to manganese(II) in transition-state-analog complexes of creatine kinase: oxygen-17 superhyperfine coupling from selectively labeled ligands

1980 • 75 citations

Properties of a CH3-blocked creatine kinase with altered catalytic activity. Kinetic consequences of the presence of the blocking group.

1977 • 75 citations

Specificity of Creatine Kinase for Guanidino Substrates

1972 • 65 citations

Magnetic resonance study of the three-dimensional structure of creatine kinase-substrate complexes. Implications for substrate specificity and catalytic mechanism.

1976 • 64 citations

Use of pH studies to elucidate the chemical mechanism of yeast hexokinase

1978 • 52 citations

Structure of metal x nucleotide complex in the creatine kinase reaction. A study with diastereomeric phosphorothioate analogs of adenosine di- and triphosphate.

1980 • 50 citations

X-ray structure of the ternary complex Zn(II)-ATP-2,2′-bipyridyl and possible model for ATP transport

1980 • 33 citations

Affinity labeling of creatine kinase by N-(2,3-epoxypropyl)-N-amidinoglycine.

1979 • 31 citations

STRUCTURAL STUDIES OF TRANSITION STATE ANALOG COMPLEXES OF CREATINE KINASE *

1973 • 28 citations

Determination of the rate-limiting steps and chemical mechanism of fructokinase by isotope exchange, isotope partitioning, and pH studies

1977 • 28 citations

Investigations of anion binding sites in transition state analogue complexes of creatine kinase by infrared spectroscopy.

1978 • 27 citations

The reaction of rabbit muscle creatine kinase with diethyl pyrocarbonate

1979 • 18 citations

Conformationally restricted creatine analogs and substrate specificity of rabbit muscle creatine kinase

1980 • 9 citations