Photoreceptor Guanylate Cyclases: A Review

NITRIC OXIDE: A Physiologic Messenger Molecule

1994 • 2,299 citations

Current Topics in Membranes and Transport

1970 • 1,240 citations

Induction by cyclic GMP of cationic conductance in plasma membrane of retinal rod outer segment

1985 • 1,213 citations

Cyclic GMP Cascade of Vision

1986 • 1,168 citations

C-Type natriuretic peptide (CNP): A new member of natriuretic peptide family identified in porcine brain

1990 • 1,099 citations

A membrane form of guanylate cyclase is an atrial natriuretic peptide receptor

1989 • 996 citations

Atrial Natriuretic Factor: A Hormone Produced by the Heart

1985 • 985 citations

G Proteins: A Family of Signal Transducers

1986 • 975 citations

Responses of retinal rods to single photons.

1979 • 971 citations

Diverse biological actions of atrial natriuretic peptide

1990 • 894 citations

Cyclic GMP synthesis and function.

1987 • 871 citations

Stimulation of guanylate cyclase by sodium nitroprusside, nitroglycerin and nitric oxide in various tissue preparations and comparison to the effects of sodium azide and hydroxylamine.

1977 • 692 citations

The photocurrent, noise and spectral sensitivity of rods of the monkey Macaca fascicularis.

1984 • 689 citations

Primary structure and functional expression from complementary DNA of the rod photoreceptor cyclic GMP-gated channel

1989 • 663 citations

Amplification and kinetics of the activation steps in phototransduction

1993 • 645 citations

Highly cooperative feedback control of retinal rod guanylate cyclase by calcium ions

1988 • 634 citations

A quantitative account of the activation steps involved in phototransduction in amphibian photoreceptors.

1992 • 632 citations

Guanylyl cyclase is a heat-stable enterotoxin receptor

1990 • 600 citations

Cyclic GMP-Activated Conductance of Retinal Photoreceptor Cells

1989 • 582 citations

Differential activation by atrial and brain natriuretic peptides of two different receptor guanylate cyclases

1989 • 579 citations

Recoverin: a Calcium Sensitive Activator of Retinal Rod Guanylate Cyclase

1991 • 569 citations

Dark Current and Photocurrent in Retinal Rods

1970 • 555 citations

Electrical responses of single cones in the retina of the turtle

1970 • 542 citations

Visual excitation and recovery

1991 • 530 citations

Specific deficit of the ON response in visual transmission by targeted disruption of the mGIuR6 gene

1995 • 474 citations

The electrical response of turtle cones to flashes and steps of light

1974 • 471 citations

Suppression by glutamate of cGMP-activated conductance in retinal bipolar cells

1990 • 465 citations

Guanyl Cyclase, an Enzyme Catalyzing the Formation of Guanosine 3',5'-Monophosphate from Guanosine Triphosphate

1969 • 391 citations

ATRIAL NATRIURETIC FACTOR AND RELATED PEPTIDE HORMONES

1991 • 368 citations

Molecular cloning and characterization of retinal photoreceptor guanylyl cyclase-activating protein

1994 • 364 citations

Photoreceptor light adaptation is mediated by cytoplasmic calcium concentration

1988 • 349 citations

Co-purification of an atrial natriuretic factor receptor and particulate guanylate cyclase from rat lung.

1986 • 338 citations

The human photoreceptor membrane guanylyl cyclase, RetGC, is present in outer segments and is regulated by calcium and a soluble activator

1994 • 338 citations

Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family

1995 • 332 citations

The Protein Kinase Domain of the ANP Receptor Is Required for Signaling

1989 • 332 citations

The localization of nitric oxide synthase in the rat eye and related cranial ganglia

1993 • 323 citations

Cloning, Sequencing, and Expression of a 24-kDa Ca2+-binding Protein Activating Photoreceptor Guanylyl Cyclase

1995 • 307 citations

Cyclic Nucleotide-Gated Ion Channels: An Extended Family With Diverse Functions

1996 • 305 citations

Guanylyl cyclase receptors.

1994 • 292 citations

The calcium feedback signal in the phototransduction cascade of vertebrate rods

1994 • 290 citations

Light-suppressible, cyclic GMP-sensitive conductance in the plasma membrane of a truncated rod outer segment

1985 • 289 citations

Evidence for Two Different Forms of Guanylate Cyclase in Rat Heart

1974 • 286 citations

Determination of Guanosine 3',5'-Monophosphate in Tissues and of Guanyl Cyclase in Rat Intestine

1969 • 281 citations

Hemi‐gap‐junction channels in solitary horizontal cells of the catfish retina.

1992 • 276 citations

A photoreceptor calcium binding protein is recognized by autoantibodies obtained from patients with cancer-associated retinopathy.

1991 • 264 citations

Cyclic GMP and calcium: The internal messengers of excitation and adaptation in vertebrate photoreceptors

1990 • 258 citations

Action of glutamate and aspartate analogues on rod horizontal and bipolar cells

1981 • 249 citations

Glutamate receptors of rod bipolar cells are linked to a cyclic GMP cascade via a G-protein

1990 • 249 citations

Purification and physiological evaluation of a guanylate cyclase activating protein from retinal rods.

1994 • 247 citations

A cGMP-gated current can control exocytosis at cone synapses

1994 • 244 citations

Cloning and expression of a second photoreceptor-specific membrane retina guanylyl cyclase (RetGC), RetGC-2.

1995 • 239 citations

Regulation of sensitivity in vertebrate rod photoreceptors by calcium

1996 • 237 citations

Two membrane forms of guanylyl cyclase found in the eye.

1995 • 237 citations

Retinal ganglion cells express a cGMP-gated cation conductance activatable by nitric oxide donors

1994 • 236 citations

The concentration of cytosolic free calcium in vertebrate rod outer segments measured with fura-2

1988 • 234 citations

The cyclic nucleotide-gated channels of vertebrate photoreceptors and olfactory epithelium

1991 • 224 citations

Molecular cloning of a retina-specific membrane guanylyl cyclase

1992 • 220 citations

Coexistence of Guanylate Cyclase and Atrial Natriuretic Factor Receptor in a 180-kD Protein

1987 • 218 citations

Detection of guanyl cyclase in mammalian tissues

1969 • 215 citations

Control of light‐sensitive current in salamander rods.

1988 • 207 citations

Guanylyl Cyclase Activating Protein

1995 • 203 citations

Two distinct forms of receptors for atrial natriuretic factor in bovine adrenocortical cells. Purification, ligand binding, and peptide mapping.

1987 • 199 citations

A 26 kd calcium binding protein from bovine rod outer segments as modulator of photoreceptor guanylate cyclase.

1991 • 198 citations

cGMP-gated conductance in retinal bipolar cells is suppressed by the photoreceptor transmitter

1991 • 194 citations

The effect of recoverin-like calcium-Binding proteins on the photoresponse of retinal rods

1993 • 194 citations

Calcium homeostasis in the outer segments of retinal rods from the tiger salamander.

1992 • 186 citations

Amplitude, kinetics, and reversibility of a light-induced decrease in guanosine 3',5'-cyclic monophosphate in frog photoreceptor membranes.

1979 • 186 citations

Visual transduction in vertebrate rods and cones: A tale of two transmitters, calcium and cyclic GMP

1986 • 178 citations

The Biochemical Pharmacology of Atrial Peptides

1989 • 174 citations

Magnitude of increase in retinal cGMP metabolic flux determined by 18O incorporation into nucleotide alpha-phosphoryls corresponds with intensity of photic stimulation.

1983 • 171 citations

Purification and identification of photoreceptor guanylate cyclase

1991 • 162 citations

Cytoplasmic calcium as the messenger for light adaptation in salamander rods.

1989 • 162 citations

Participation of adenosine 5′‐triphosphate in the activation of membrane‐bound guanylate cyclase by the atrial natriuretic factor

1987 • 160 citations

Adenine nucleotides are required for activation of rat atrial natriuretic peptide receptor/guanylyl cyclase expressed in a baculovirus system

1991 • 158 citations

Calcium modulation of cyclic GMP synthesis in rat visual cells

1982 • 153 citations

Calcium controls light-triggered formation of catalytically active rhodopsin

1994 • 153 citations

Adenyl Cyclase as a Link between Photon Capture and Changes in Membrane Permeability of Frog Photoreceptors

1971 • 152 citations

Incorporation of calcium buffers into salamander retinal rods: a rejection of the calcium hypothesis of phototransduction.

1986 • 150 citations

Primary structure and functional expression of the human receptor for Escherichia coli heat-stable enterotoxin.

1991 • 148 citations

Evidence that cyclic GMP regulates membrane potential in rod photoreceptors

1979 • 144 citations

Elemental distribution in Rana pipiens retinal rods: quantitative electron probe analysis.

1985 • 143 citations

Family of cyclic nucleotide gated ion channels

1995 • 143 citations

The Membrane Guanylyl Cyclase, Retinal Guanylyl Cyclase-1, Is Activated through Its Intracellular Domain

1996 • 139 citations

Guanylate cyclase of isolated bovine retinal rod axonemes

1979 • 137 citations

Cyclic GMP injected into retinal rod outer segments increases latency and amplitude of response to illumination.

1978 • 137 citations

Calcium feedback and sensitivity regulation in primate rods.

1991 • 132 citations

Structural and functional characterization of the rod outer segment membrane guanylate cyclase

1994 • 132 citations

Atrial natriuretic factor R1 receptor from bovine adrenal zona glomerulosa: purification, characterization, and modulation by amiloride

1988 • 132 citations

Ca2+ modulation of the cGMP‐gated channel of bullfrog retinal rod photoreceptors.

1995 • 131 citations

Ultrastructural localization of retinal guanylate cyclase in human and monkey retinas

1994 • 131 citations

Calcium and cyclic nucleotide regulation in incubated mouse retinas.

1978 • 131 citations

Amplification of phosphodiesterase activation is greatly reduced by rhodopsin phosphorylation

1986 • 130 citations

Functional Characterization of a Guanylyl Cyclase-activating Protein from Vertebrate Rods

1996 • 126 citations

Effects on the photoresponse of calcium buffers and cyclic GMP incorporated into the cytoplasm of retinal rods

1985 • 125 citations

Multiple classes of glutamate receptor on depolarizing bipolar cells in retina

1987 • 122 citations

Nitric oxide synthase in Muller cells and neurons of salamander and fish retina

1994 • 120 citations

Guanosine 3',5'‐cyclic monophosphate‐activated conductance studied in a truncated rod outer segment of the toad.

1988 • 119 citations

The Molecular Mechanism of Photoreception

1986 • 118 citations

Purification and characterization of two types of atrial natriuretic factor receptors from bovine adrenal cortex: Guanylate cyclase-linked and cyclase-free receptors

1987 • 117 citations

Cyclic Nucleotide Phosphodiesterase: High Activity in a Mammalian Photoreceptor

1972 • 115 citations

Effects of Cyclic GMP on Smooth Muscle Relaxation

1994 • 113 citations

Guanyl cyclase. Determination of enzyme activity

1969 • 112 citations

The cGMP-phosphodiesterase and its contribution to sensitivity regulation in retinal rods

1995 • 110 citations

GTP hydrolysis in intact rod outer segments and the transmitter cycle in visual excitation

1979 • 108 citations

Cyclic nucleotide-gated channels: an expanding new family of ion channels.

1994 • 108 citations

Free calcium concentrations in bullfrog rods determined in the presence of multiple forms of Fura-2

1994 • 106 citations

Intracellular biochemical manipulation of phototransduction in detached rod outer segments.

1987 • 105 citations

Regulation of cyclic GMP metabolism in toad photoreceptors. Definition of the metabolic events subserving photoexcited and attenuated states.

1988 • 103 citations

Characterization of ATP-stimulated guanylate cyclase activation in rat lung membranes

1990 • 103 citations

Calcium Modulation of Bovine Photoreceptor Guanylate Cyclase

1996 • 100 citations

Characterization of guanylate cyclase activity in single retinal rod outer segments

1995 • 99 citations

Localization of particulate guanylate cyclase in plasma membranes and microsomes of rat liver.

1975 • 98 citations

cGMP Signaling through cAMP- and cGMP-Dependent Protein Kinases

1995 • 98 citations

Light-induced decreases in cGMP concentration precede changes in membrane permeability in frog rod photoreceptors.

1984 • 96 citations

Guanyl cyclase in a mammalian photoreceptor

1973 • 95 citations

Inactivation of EF-hands Makes GCAP-2 (p24) a Constitutive Activator of Photoreceptor Guanylyl Cyclase by Preventing a Ca2+-induced “Activator-to-Inhibitor” Transition

1996 • 95 citations

Visual transduction in dialysed detached rod outer segments from lizard retina.

1993 • 94 citations

Control of Guanylate Cyclase Activity in the Rod Outer Segment

1973 • 93 citations

Two forms of guanylate cyclase in mammalian tissues and possible mechanisms for their regulation

1975 • 92 citations

Heme Stoichiometry of Heterodimeric Soluble Guanylate Cyclase

1995 • 90 citations

Differential Laminar Expression of Particulate and Soluble Guanylate Cyclase Genes in Rat Retina

1993 • 89 citations

Light-induced increases in cGMP metabolic flux correspond with electrical responses of photoreceptors.

1986 • 89 citations

Guanylate cyclase from bovine rod outer segments: solubilization, partial purification, and regulation by inorganic pyrophosphate

1990 • 89 citations

Modulation of transduction gain in light adaptation of retinal rods

1994 • 85 citations

A structural motif that defines the ATP-regulatory module of guanylate cyclase in atrial natriuretic factor signalling

1992 • 83 citations

Polymorphism in purified guanylate cyclase from vertebrate rod photoreceptors.

1991 • 78 citations

Cloning and expression of an ATP-regulated human retina C-type natriuretic factor receptor guanylate cyclase

1993 • 77 citations

Cytoplasmic free calcium concentration in dark-adapted retinal rod outer segments

1989 • 77 citations

Guanylate cyclase in rod outer segments of the toad retina

1986 • 77 citations

Molecular characterization of human and mouse photoreceptor guanylate cyclase-activating protein (GCAP) and chromosomal localization of the human gene.

1994 • 75 citations

Sodium‐dependent calcium extrusion and sensitivity regulation in retinal cones of the salamander.

1989 • 75 citations

Dual regulation of atrial natriuretic factor‐dependent guanylate cyclase activity by ATP

1991 • 72 citations

The kinetics of inactivation of the rod phototransduction cascade with constant Ca2+i.

1996 • 72 citations

Identification of a G-protein in depolarizing rod bipolar cells

1993 • 72 citations

Frog rod outer segments with attached inner segment ellipsoids as an in vitro model for photoreceptors on the retina.

1985 • 72 citations

CYCLIC NUCLEOTIDE PHOSPHODIESTERASE OF THE BOVINE RETINA: ACTIVITY, SUBCELLULAR DISTRIBUTION AND KINETIC PARAMETERS

1974 • 71 citations

Stereochemical course of the reaction catalyzed by guanylate cyclase from bovine retinal rod outer segments.

1990 • 70 citations

EFFECTS OF LIGHT ON CYCLIC GMP METABOLISM IN RETINAL PHOTORECEPTORS

1976 • 70 citations

Site-directed mutational analysis of a membrane guanylate cyclase cDNA reveals the atrial natriuretic factor signaling site.

1991 • 69 citations

Characterization of Guanylate cyclase of rod outer segments of the bovine retina

1978 • 65 citations

Association of guanylate cyclase with the axoneme of retinal rods

1980 • 64 citations

Subcellular localization of guanylate cyclase

1975 • 64 citations

Structural and Biochemical Identity of Retinal Rod Outer Segment Membrane Guanylate Cyclase

1993 • 64 citations

Distribution of enzyme activities in subcellular fractions of bovine retina.

1976 • 61 citations

Molecular Characterization of S100A1-S100B Protein in Retina and Its Activation Mechanism of Bovine Photoreceptor Guanylate Cyclase

1996 • 60 citations

The carboxyl region contains the catalytic domain of the membrane form of guanylate cyclase.

1990 • 60 citations

Ca2+ Dependence of Dark- and Light-Adapted Flash Responses in Rod Photoreceptors

1996 • 59 citations

Transduction in vertebrate photoreceptors: the roles of cyclic GMP and calcium

1986 • 59 citations

Physiological evidence that light-mediated decrease in cyclic GMP is an intermediary process in retinal rod transduction.

1982 • 58 citations

Allosteric modulation by ATP of the bovine adrenal natriuretic factor R1 receptor functions

1991 • 58 citations

Influence of light and calcium on guanosine 5'-triphosphate in isolated frog rod outer segments.

1979 • 58 citations

Immunohistochemical study of S-100 protein in the postnatal development of M�ller cells and astrocytes in the rat retina

1984 • 57 citations

The bovine rod outer segment guanylate cyclase, ROS-GC, is present in both outer segment and synaptic layers of the retina

1995 • 56 citations

GUANYLATE CYCLASES IN CNS: ENZYMATIC CHARACTERISTICS OF SOLUBLE AND PARTICULATE ENZYMES FROM MOUSE CEREBELLUM AND RETINA

1978 • 55 citations

Solubilization of guanylyl cyclase from bovine rod outer segments and effects of lowering Ca2+ and nitro compounds

1991 • 55 citations

Core sequence of ATP regulatory module in receptor guanylate cyclases

1993 • 53 citations

Guanylate Cyclase: Inhibition by Light in Retinal Photoreceptors

1974 • 53 citations

cGMP‐mediated effects on the physiology of bovine and human retinal Müller (glial) cells.

1996 • 52 citations

Regulation of cGMP levels by guanylate cyclase in truncated frog rod outer segments.

1989 • 51 citations

Adrenocorticotropin-dependent particulate guanylate cyclase in rat adrenal and adrenocortical carcinoma: Comparison of its properties with soluble guanylate cyclase and its relationship with ACTH-induced steroidogenesis

1982 • 51 citations

Nucleotide Inhibitors and Activators of Retinal Guanylyl Cyclase

1994 • 51 citations

A novel calcium-dependent activator of retinal rod outer segment membrane guanylate cyclase

1995 • 50 citations

Activation of Bovine Photoreceptor Guanylate Cyclase by S100 Proteins

1996 • 50 citations

Structural and Functional Characterization of a Second Subfamily Member of the Calcium-Modulated Bovine Rod Outer Segment Membrane Guanylate Cyclase, ROS-GC2

1997 • 49 citations

The Photoreceptor Guanylate Cyclase Is an Autophosphorylating Protein Kinase

1996 • 47 citations

Responses of rod bipolar cells isolated from dogfish retinal slices to concentration-jumps of glutamate

1994 • 45 citations

Light- and GTP-activated photoreceptor phosphodiesterase: regulation by a light-activated GTPase and identification of rhodopsin as the phosphodiesterase binding site.

1978 • 45 citations

Opposing adenine nucleotide-dependent pathways regulate guanylyl cyclase C in rat intestine.

1994 • 44 citations

Cyclic nucleotide-gated channels in visual and olfactory transduction

1995 • 42 citations

The Nature and Identity of the Internal Excitational Transmitter of Vertebrate Phototransduction

1987 • 41 citations

Actions of Ca2+ on an Early Stage in Phototransduction Revealed by the Dynamic Fall in Ca2+ Concentration during the Bright Flash Response

1997 • 40 citations

Light adaptation and the rising phase of the flash photocurrent of salamander retinal rods.

1995 • 39 citations

Adenine nucleotide regulation of particulate guanylate cyclase from rat lung

1991 • 39 citations

Inorganic pyrophosphatase from bovine retinal rod outer segments.

1992 • 39 citations

Genetically tailored atrial natriuretic factor‐dependent guanylate cyclase Immunological and functional identity with 180 kDa membrane guanylate cyclase and ATP signaling site

1992 • 38 citations

Third calcium-modulated rod outer segment membrane guanylate cyclase transduction mechanism.

1998 • 38 citations

The role of cyclic nucleotides in visual excitation

1973 • 38 citations

Static and dynamic actions of cytoplasmic Ca2+ in the adaptation of responses to saturating flashes in salamander rods.

1996 • 37 citations

cGMP immunocytochemistry in aorta, kidney, retina and brain tissues of the rat after perfusion with nitroprusside

1989 • 37 citations

Molecular Mechanisms of Photoreceptor Transduction

1981 • 33 citations

Activation by PKC of the Ca2+-sensitive guanylyl cyclase in bovine retinal rod outer segments measured with optical assays

1995 • 32 citations

Time-dependent reduction of glutamate current in retinal bipolar cells

1990 • 32 citations

Expression of guanylate cyclase-A mRNA in the rat retina: Detection using polymerase chain reaction

1992 • 31 citations

Kinetics of desensitization induced by saturating flashes in toad and salamander rods.

1996 • 30 citations

Purification and characterization of the 180-kDa membrane guanylate cyclase containing atrial natriuretic factor receptor from rat adrenal gland and its regulation by protein kinase C

1989 • 30 citations

Effect of GTP analogues on purified soluble guanylate cyclase.

1982 • 29 citations

The glycine residue of ATP regulatory module in receptor guanylate cyclases that is essential in natriuretic factor signaling

1993 • 29 citations

Molecular diversity of cyclic nucleotide-gated cation channels

1995 • 27 citations

Phosphorylation of recoverin, the calcium‐sensitive activator of photoreceptor guanylyl cyclase

1991 • 27 citations

Purification of guanylyl cyclase from rod outer segments

1991 • 25 citations

Demonstration of ACTH—Sensitive particulate guanylate cyclase in adrenocortical carcinoma

1981 • 24 citations

ATP modulation of the ligand binding and signal transduction activities of the type C natriuretic peptide receptor guanylate cyclase

1995 • 24 citations

Glutamic Acid-332 Residue of the Type C Natriuretic Peptide Receptor Guanylate Cyclase Is Important for Signaling

1994 • 24 citations

Purification and primary structure of Capl, an S-100-related calcium-binding protein isolated from bovine retina.

1994 • 23 citations

Interactions of nucleotide analogs with rod outer segment guanylate cyclase

1991 • 23 citations

ATP Bimodal Switch That Regulates the Ligand Binding and Signal Transduction Activities of the Atrial Natriuretic Factor Receptor Guanylate Cyclase

1995 • 23 citations

Molecular Aspects of Cyclic GMP Signaling

1995 • 23 citations

The Bovine Photoreceptor Outer Segment Guanylate Cyclase: Purification, Kinetic Properties, and Molecular Size

1995 • 22 citations

Bovine retinal rod guanyl cyclase represents a new N‐glycosylated subtype of membrane‐bound guanyl cyclases

1994 • 21 citations

Regulation of bovine rod outer segment membrane guanylate cyclase by ATP, phosphodiesterase and metal ions

1995 • 20 citations

Immunohistochemical localization of S-100 protein in the retina, ciliary body and iris of human fetuses

1985 • 20 citations

Nitric Oxide/Cyclic GMP‐mediated Signal Transduction^a

1994 • 19 citations

Immunochemical detection of S-100 protein in non-nervous structures of the rabbit eye

1985 • 19 citations

Trypsin solubilization of rat liver membrane-bound guanylate cyclase results in a form kinetically distinct from the cytosolic enzyme.

1981 • 17 citations

Distinct inhibitory ATP-regulated modulatory domain (ARMi) in membrane guanylate cyclases

1996 • 16 citations

Distribution and regulation of natriuretic factor-R1C receptor subtypes in mammalian cell lines

1993 • 15 citations

Membrane guanylate cyclase signal transduction system.

1997 • 13 citations

The cGMP-gated channel of photoreceptor cells: Its structural properties and role in phototransduction

1995 • 13 citations

Cyclic Nucleotide-Gated Nonselective Cation Channels: A Multifunctional Gene Family

1993 • 12 citations

Cyclic GMP as a Second Messenger in the Cardiovascular System.

1995 • 10 citations

Regulation of intracellular cyclic GMP concentration by light and calcium in electropermeabilized rod photoreceptors.

1994 • 9 citations

Ubiquitous and bifunctional 180 kDa atrial natriuretic factor-dependent guanylate cyclase

1991 • 8 citations

The effects of light on cyclic nucleotide metabolism of isolated cone photoreceptors

1992 • 8 citations

Control of intracellular calcium in vertebrate photoreceptors

1989 • 5 citations