Progesterone receptors in mammary gland development and tumorigenesis.

Sequence and Characterization of a Coactivator for the Steroid Hormone Receptor Superfamily

1995 • 2,390 citations

A CBP Integrator Complex Mediates Transcriptional Activation and AP-1 Inhibition by Nuclear Receptors

1996 • 2,183 citations

Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities.

1995 • 1,834 citations

Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B.

1990 • 1,510 citations

Cyclin D1 provides a link between development and oncogenesis in the retina and breast

1995 • 1,017 citations

Effect of Hormone Replacement Therapy on Breast Cancer Risk: Estrogen Versus Estrogen Plus Progestin

2000 • 879 citations

Human progesterone receptor A form is a cell- and promoter-specific repressor of human progesterone receptor B function.

1993 • 749 citations

Non-genomic and genomic effects of steroids on neural activity

1991 • 731 citations

Breast Cancer

1992 • 695 citations

Subgroup of Reproductive Functions of Progesterone Mediated by Progesterone Receptor-B Isoform

2000 • 693 citations

A Mutator Phenotype in Cancer 1

2001 • 675 citations

Dissociation between steroid receptor expression and cell proliferation in the human breast.

1997 • 623 citations

Molecular interactions of steroid hormone receptor with its enhancer element: Evidence for receptor dimer formation

1988 • 600 citations

Differential Gene Regulation by the Two Progesterone Receptor Isoforms in Human Breast Cancer Cells

2002 • 566 citations

Essential function of Wnt-4 in mammary gland development downstream of progesterone signaling

2000 • 476 citations

A paracrine role for the epithelial progesterone receptor in mammary gland development

1998 • 452 citations

The N-terminal region of the chicken progesterone receptor specifies target gene activation

1988 • 425 citations

The Opposing Transcriptional Activities of the Two Isoforms of the Human Progesterone Receptor Are Due to Differential Cofactor Binding

2000 • 375 citations

TRANSCRIPTION ACTIVATION BY ESTROGEN AND PROGESTERONE RECEPTORS

1991 • 372 citations

Hormone and antihormone induce distinct conformational changes which are central to steroid receptor activation.

1992 • 363 citations

Toward the Primary Prevention of Cancer

1991 • 361 citations

Mammary gland development and tumorigenesis in estrogen receptor knockout mice.

1997 • 354 citations

The epidemiology of breast cancer

1991 • 322 citations

A third transactivation function (AF3) of human progesterone receptors located in the unique N-terminal segment of the B-isoform.

1994 • 313 citations

Colocalization of Progesterone Receptors A and B by Dual Immunofluorescent Histochemistry in Human Endometrium during the Menstrual Cycle1

1999 • 266 citations

An adjunct mammary epithelial cell population in parous females: its role in functional adaptation and tissue renewal

2002 • 264 citations

Loss of Co-ordinate Expression of Progesterone Receptors A and B is an Early Event in Breast Carcinogenesis

2002 • 245 citations

Transgenic mice carrying an imbalance in the native ratio of A to B forms of progesterone receptor exhibit developmental abnormalities in mammary glands

1998 • 203 citations

The Chicken Progesterone Receptor A and B Isoforms Are Products of an Alternate Translation Initiation Event

1989 • 196 citations

Murine mammary gland carcinogenesis is critically dependent on progesterone receptor function.

1999 • 190 citations

Mapping and Characterization of the Functional Domains Responsible for the Differential Activity of the A and B Isoforms of the Human Progesterone Receptor

1997 • 187 citations

Dopamine requires the unoccupied progesterone receptor to induce sexual behavior in mice.

1996 • 178 citations

A limiting factor mediates the differential activation of promoters by the human progesterone receptor isoforms.

1992 • 171 citations

Relative expression of progesterone receptors A and B in endometrioid cancers of the endometrium.

2001 • 171 citations

Endocrine Defects in Mice Carrying a Null Mutation for the Progesterone Receptor Gene*

1997 • 169 citations

IGF-2 Is a Mediator of Prolactin-Induced Morphogenesis in the Breast

2002 • 168 citations

Hormone-Dependent Interaction between the Amino- and Carboxyl-Terminal Domains of Progesterone Receptor in Vitro and in Vivo

1999 • 167 citations

Characterization of progesterone receptor A and B expression in human breast cancer.

1995 • 163 citations

Absence of Gonadotropin Surges and Gonadotropin-Releasing Hormone Self-Priming in Ovariectomized (OVX), Estrogen (E2)-Treated, Progesterone Receptor Knockout (PRKO) Mice*

1999 • 161 citations

Persistent Parity-Induced Changes in Growth Factors, TGF-β3, and Differentiation in the Rodent Mammary Gland

2002 • 157 citations

C/EBPβ (CCAAT/Enhancer Binding Protein) Controls Cell Fate Determination during Mammary Gland Development

2000 • 156 citations

A Novel LacZ Reporter Mouse Reveals Complex Regulation of the Progesterone Receptor Promoter During Mammary Gland Development

2002 • 146 citations

An N-terminal Inhibitory Function, IF, Suppresses Transcription by the A-isoform but Not the B-isoform of Human Progesterone Receptors

1998 • 145 citations

Impact of progesterone receptor on cell-fate decisions during mammary gland development

2000 • 138 citations

Search for a Killer: Focus Shifts from Fat to Hormones

1993 • 135 citations

p53 is a potential mediator of pregnancy and hormone-induced resistance to mammary carcinogenesis

2001 • 135 citations

Differential expression of uterine progesterone receptor forms A and B during the menstrual cycle

1997 • 134 citations

The role of prolactin and growth hormone in mammary gland development

2002 • 132 citations

Effect of Hormone Replacement Therapy on Breast Cancer Risk: Estrogen Versus Estrogen Plus Progestin

2000 • 129 citations

Heterogeneity of progesterone receptors A and B expression in human endometrial glands and stroma

2000 • 123 citations

Progestogens in hormonal replacement therapy: new molecules, risks, and benefits

2002 • 122 citations

Persistent Changes in Gene Expression Induced by Estrogen and Progesterone in the Rat Mammary Gland

2001 • 107 citations

Disruption of Steroid and Prolactin Receptor Patterning in the Mammary Gland Correlates with a Block in Lobuloalveolar Development

2002 • 106 citations

Effect of Overexpression of Progesterone Receptor A on Endogenous Progestin-Sensitive Endpoints in Breast Cancer Cells

1999 • 96 citations

Impaired Mammary Gland Development in Cyl-1−/− Mice during Pregnancy and Lactation Is Epithelial Cell Autonomous

1999 • 82 citations

Hormone-induced protection against breast cancer.

2002 • 81 citations

Progesterone receptors in the mouse mammary duct: distribution and developmental regulation.

1996 • 76 citations

Selective vulnerability of pigmented dopaminergic neurons in Parkinson's disease

1989 • 75 citations

Reversal of the antitumor effects of tamoxifen by progesterone in the 7,12-dimethylbenzanthracene-induced rat mammary carcinoma model.

1987 • 74 citations

Validity of mouse mammary tumour models for human breast cancer: Comparative pathology

2001 • 71 citations

Estrogen-progestin replacement and risk of breast cancer.

2000 • 52 citations

Mechanisms of Hormonal Prevention of Breast Cancer

2001 • 49 citations

Early exposure of the rat mammary gland to estrogen and progesterone blocks co-localization of estrogen receptor expression and proliferation

2001 • 46 citations

Progesterone receptors - animal models and cell signaling in breast cancer: Progesterone's role in mammary gland development and tumorigenesis as disclosed by experimental mouse genetics

2002 • 44 citations

Refractoriness to mammary carcinogenesis in the parous mouse is reversible by hormonal stimulation induced by pituitary isografts

1995 • 32 citations

The Endocrine Prevention of Breast Cancer

1995 • 32 citations

Medroxyprogesterone acetate enhances spontaneous mammary tumorigenesis and uterine adenomyosis in mice

1988 • 28 citations

Benefits and risks of hormone replacement therapy (HRT)

1995 • 27 citations

Role of the progesterone receptor (PR) in susceptibility of mouse mammary gland to 7,12-dimethylbenz[a]anthracene-induced hormone-independent preneoplastic lesions in vitro

2002 • 25 citations