Mapping and Characterization of the Functional Domains Responsible for the Differential Activity of the A and B Isoforms of the Human Progesterone Receptor

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B.

1990 • 1,510 citations

Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors.

1992 • 829 citations

Human progesterone receptor A form is a cell- and promoter-specific repressor of human progesterone receptor B function.

1993 • 749 citations

Progestin Regulation of Cellular Proliferation*

1990 • 659 citations

MINIREVIEW: The Steroid Receptor Superfamily: More Excitement Predicted for the Future

1990 • 489 citations

Construction of plasmids that expressE.coli β-galactosidase in mammalian cells

1989 • 458 citations

The N-terminal region of the chicken progesterone receptor specifies target gene activation

1988 • 425 citations

The mechanism of RU486 antagonism is dependent on the conformation of the carboxy-terminal tail of the human progesterone receptor

1992 • 381 citations

The A and B isoforms of the human progesterone receptor operate through distinct signaling pathways within target cells.

1994 • 343 citations

Agonistic and antagonistic activities of RU486 on the functions of the human progesterone receptor.

1990 • 333 citations

A third transactivation function (AF3) of human progesterone receptors located in the unique N-terminal segment of the B-isoform.

1994 • 313 citations

The contribution of the N- and C-terminal regions of steroid receptors to activation of transcription is both receptor and cell-specific

1989 • 299 citations

Progesterone antagonism of the oestrogen receptor and oestrogen-induced uterine growth

1975 • 273 citations

Regulation of Estrogen Receptor Messenger Ribonucleic Acid and Protein Levels in Human Breast Cancer Cell Lines by Sex Steroid Hormones, Their Antagonists, and Growth Factors

1989 • 261 citations

Transcriptional activation by the estrogen receptor requires a conformational change in the ligand binding domain.

1993 • 249 citations

In SituPhotolinked Nuclear Progesterone Receptors of Human Breast Cancer Cells: Subunit Molecular Weights after Transformation and Translocation*

1983 • 238 citations

Purification of unactivated progesterone receptor and identification of novel receptor-associated proteins.

1990 • 229 citations

Identification of a New Subclass of Alu DNA Repeats Which Can Function as Estrogen Receptor-dependent Transcriptional Enhancers

1995 • 226 citations

RU486 exerts antiestrogenic activities through a novel progesterone receptor A form-mediated mechanism.

1994 • 214 citations

Cloning and sequence analysis of rabbit progesterone-receptor complementary DNA.

1986 • 204 citations

The A and B forms of the chicken progesterone receptor arise by alternate initiation of translation of a unique mRNA

1987 • 202 citations

Inhibitory Cross-Talk between Steroid Hormone Receptors: Differential Targeting of Estrogen Receptor in the Repression of Its Transcriptional Activity by Agonist- and Antagonist-Occupied Progestin Receptors

1995 • 187 citations

A limiting factor mediates the differential activation of promoters by the human progesterone receptor isoforms.

1992 • 171 citations

EFFECTS OF PROGESTINS ON ESTRADIOL RECEPTOR LEVELS IN HUMAN ENDOMETRIUM

1975 • 163 citations

The Subunit Structure of Human Breast Cancer Progesterone Receptors: Characterization by Chromatography and Photoaffinity Labeling*

1983 • 142 citations

High level expression of biologically active estrogen receptor in Saccharomyces cerevisiae

1991 • 141 citations

Dimerization of mammalian progesterone receptors occurs in the absence of DNA and is related to the release of the 90-kDa heat shock protein.

1991 • 133 citations

Novel estrogen response elements identified by genetic selection in yeast are differentially responsive to estrogens and antiestrogens in mammalian cells.

1994 • 92 citations

Steroid Hormone-Dependent Interaction of Human Progesterone Receptor with its Target Enhancer Element

1988 • 92 citations

Murine progesterone receptor exists predominantly as the 83-kilodalton ‘A’ form

1991 • 89 citations

Differential effect of forms A and B of human progesterone receptor on estradiol-dependent transcription.

1994 • 77 citations

Hinge and Amino-Terminal Sequences Contribute to Solution Dimerization of Human Progesterone Receptor

1997 • 73 citations

Progestin Regulation of Estrogen Receptor Messenger RNA in Human Breast Cancer Cells

1990 • 61 citations

Progesterone enhances target gene transcription by receptor free of heat shock proteins hsp90, hsp56, and hsp70.

1991 • 59 citations

Steroid receptor folding by heat-shock proteins and composition of the receptor heterocomplex

1992 • 51 citations

The nonactivated progesterone receptor is a nuclear heterooligomer.

1990 • 47 citations

Definition of the cellular mechanisms which distinguish between hormone and antihormone activated steroid receptors.

1994 • 33 citations

A novel, highly regulated, rapidly inducible system for the expression of chicken progesterone receptor, cPRA, in Saccharomyces cerevisiae

1992 • 16 citations