CD4+, but not CD8+, T cells from mammary tumor-bearing mice have a down-regulated production of IFN-gamma: role of phosphatidyl serine.

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1986 • 7,504 citations

Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands.

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A TH1→TH2 switch is a critical step in the etiology of HIV infection

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Purification, sequence, and cellular localization of a novel chromosomal protein that binds to Methylated DNA

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Differential production of interferon-γ and interleukin-4 in response to Th1- and Th2-stimulating pathogens by γδ T cells in vivo

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Separation of mouse spleen cells by passage through columns of sephadex G-10

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Simultaneous production of IL-2, IL-4, and IFN-gamma by activated human CD4+ and CD8+ T cell clones.

1988 • 509 citations

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Interleukin-12 primes human CD4 and CD8 T cell clones for high production of both interferon-gamma and interleukin-10.

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Flow cytometric determination of cytokines in activated murine T helper lymphocytes: Expression of interleukin‐10 in interferon‐γ and in interleukin‐4‐expressing cells

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Interferons with Special Emphasis on the Immune System

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The altered tumoricidal capacity of macrophages isolated from tumor-bearing mice is related to reduce expression of the inducible nitric oxide synthase gene.

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Differentiation of the T helper phenotypes by analysis of the methylation state of the IFN-gamma gene.

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Use of a HpaII-polymerase chain reaction assay to study DNA methylation in the Pgk-1 CpG island of mouse embryos at the time of X-chromosome inactivation.

1990 • 183 citations

Heterogeneity of single cell cytokine gene expression in clonal T cell populations.

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The Nuclear Factor YY1 Suppresses the Human Gamma Interferon Promoter through Two Mechanisms: Inhibition of AP1 Binding and Activation of a Silencer Element

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Hematopoietic growth factors secreted by seven human pleural mesothelioma cell lines: Interleukin‐6 production as a common feature

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1990 • 130 citations

Gradual Loss of T-Helper 1 Populations in Spleen of Mice During Progressive Tumor Growth

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Hypomethylation of the interferon‐γ gene correlates with its expression by primary T‐lineage cells

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Production of colony-stimulating factor by tumor cells and the factor-mediated induction of suppressor cells.

1988 • 112 citations

Interferon-γ: Producer cells, activation stimuli, and molecular genetic regulation

1990 • 110 citations

Induction of a Th2 population from a polarized Leishmania-specific Th1 population by in vitro culture with IL-4.

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Isolation of a nitric oxide inhibitor from mammary tumor cells and its characterization as phosphatidyl serine.

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Down-regulation of IL-12, not a shift from a T helper-1 to a T helper-2 phenotype, is responsible for impaired IFN-gamma production in mammary tumor-bearing mice.

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Splenic Macrophages From Tumor-Bearing Mice Co-Expressing MAC-1 and MAC-2 Antigens Exert Immunoregulatory Functions Via Two Distinct Mechanisms

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Identification of enhancer-like elements in human IFN-gamma genomic DNA.

1990 • 61 citations

A correlation between GM‐CSF gene expression and metastases in murine tumors

1991 • 61 citations

Analysis of T Helper and Suppressor Lymphocyte Subsets in Relation to the Clinical Stage of Solid Neoplasms

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Modulation of the Immune System by Mammary Tumor-Derived Factors

1991 • 32 citations

Development of IFN-gamma-producing CD8+ gamma delta+ T lymphocytes and IL-2-producing CD4+ alpha beta+ T lymphocytes during contact sensitivity.

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Response of Hyperplastic Alveolar Nodule Outgrowth-Line D1 to Mammary Tumor Virus, Nodule-Inducing Virus, and Prolonged Hormonal Stimulation Acting Singly and in Combination<xref ref-type="fn" rid="FN2">2</xref>

1969 • 31 citations

Uudermethylation of interferon-γ gene in human T cell lines and normal T lymphocytes

1986 • 28 citations

Characterization of nuclear protein binding to the interferon‐γ promoter in quiescent and activated human T cells

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In vivo and in vitro production of haemopoietic colony-stimulating activity by murine cell lines of different origin: a frequent finding

1989 • 23 citations

Inhibition of IFN-γ induction of class II MHC genes by cAMP and prostaglandins

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Phosphatidyl serine is involved in the reduced rate of transcription of the inducible nitric oxide synthase gene in macrophages from tumor-bearing mice.

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In vitro immune responses to viral and tumor antigens in murine breast cancer.

1976 • 17 citations

Human gamma interferon induction by staphylococcal protein a: Effector cells, kinetics and the effect of prostaglandin, indomethacin, ibuprofen and aspirin

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IMPAIRED ACTIVATION OF TUMORICIDAL FUNCTION IN MACROPHAGES FROM MAMMARY-TUMOR BEARERS - THE ROLE OF IFN-GAMMA

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Splenic alterations during mammary tumorigenesis: diverse effects on different immune parameters.

1981 • 9 citations

Interferon and Host Defense Systems

1983 • 8 citations

Characterization of the effector cells mediating an "innocent bystander" cytotoxicity reaction induced by a syngeneic mammary adenocarcinoma in mice.

1984 • 5 citations

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1981 • 1 citations