Missense mutation of the interleukin-12 receptor β1 chain–encoding gene is associated with impaired immunity againstMycobacterium avium complex infection

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1998 • 1,253 citations

A Mutation in the Interferon-γ –Receptor Gene and Susceptibility to Mycobacterial Infection

1996 • 1,174 citations

Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes

1994 • 1,066 citations

Regulation of the Interleukin (IL)-12R β2 Subunit Expression in Developing T Helper 1 (Th1) and Th2 Cells

1997 • 1,022 citations

Interferon-γ –Receptor Deficiency in an Infant with Fatal Bacille Calmette–Guérin Infection

1996 • 869 citations

Impairment of Mycobacterial Immunity in Human Interleukin-12 Receptor Deficiency

1998 • 837 citations

Severe Mycobacterial and Salmonella Infections in Interleukin-12 Receptor-Deficient Patients

1998 • 812 citations

Selective Expression of an Interleukin-12 Receptor Component by Human T Helper 1 Cells

1997 • 783 citations

The Association of Atopy with a Gain-of-Function Mutation in the α Subunit of the Interleukin-4 Receptor

1997 • 743 citations

Interleukin 12 (IL-12) Is Crucial to the Development of Protective Immunity in Mice Intravenously Infected with Mycobacterium tuberculosis

1997 • 696 citations

A functional interleukin 12 receptor complex is composed of two β-type cytokine receptor subunits

1996 • 690 citations

5-Methylcytosine as an Endogenous Mutagen in the Human LDL Receptor and p53 Genes

1990 • 643 citations

Characterization of a human immunodeficiency virus neutralizing monoclonal antibody and mapping of the neutralizing epitope

1988 • 412 citations

Inherited interleukin 12 deficiency in a child with bacille Calmette-Guérin and Salmonella enteritidis disseminated infection.

1998 • 405 citations

The mutational spectrum of single base-pair substitutions causing human genetic disease: patterns and predictions

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Partial interferon-gamma receptor 1 deficiency in a child with tuberculoid bacillus Calmette-Guérin infection and a sibling with clinical tuberculosis.

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Novel human immunodeficiencies reveal the essential role of type-1 cytokines in immunity to intracellular bacteria

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Expression cloning of a human IL-12 receptor component. A new member of the cytokine receptor superfamily with strong homology to gp130.

1994 • 309 citations

Treatment of Refractory Disseminated Nontuberculous Mycobacterial Infection With Interferon Gamma: A Preliminary Report

1994 • 297 citations

Complete and tissue-independent methylation of CpG sites in the p53 gene: implications for mutations in human cancers.

1995 • 253 citations

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1992 • 204 citations

Mutations of the CD40 Ligand Gene and Its Effect on CD40 Ligand Expression in Patients With X-Linked Hyper IgM Syndrome

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Human herpesvirus-6 enhances natural killer cell cytotoxicity via IL-15.

1996 • 148 citations

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1992 • 139 citations

X-CGDbase: a database of X-CGD-causing mutations

1996 • 73 citations

X-CGDbase: a database of X-CGD-causing mutations

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Functional Properties of Antigen-Specific T Cells Infected by Human T-Cell Leukemia-Lymphoma Virus (HTLV-I)

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T3 surface molecules on adult T cell leukemia cells are modulated in vivo

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NK cell recognition of MHC class I. NK cells are sensitive to peptide-binding groove and surface alpha-helical mutations that affect T cells.

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Discordant gene and surface expression of the T-cell receptor/CD3 complex in adult T-cell leukemia cells.

1991 • 24 citations