Immune Deficiency Presenting as Mycobacterial Infection

CELLULAR RESPONSES TO INTERFERON-γ

1997 • 2,885 citations

An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection.

1993 • 2,410 citations

Disseminated tuberculosis in interferon gamma gene-disrupted mice.

1993 • 1,982 citations

A Mutation in the Interferon-γ –Receptor Gene and Susceptibility to Mycobacterial Infection

1996 • 1,174 citations

Interferon-γ –Receptor Deficiency in an Infant with Fatal Bacille Calmette–Guérin Infection

1996 • 869 citations

Requirement for Transcription Factor IRF-1 in NO Synthase Induction in Macrophages

1994 • 840 citations

Impairment of Mycobacterial Immunity in Human Interleukin-12 Receptor Deficiency

1998 • 837 citations

Severe Mycobacterial and Salmonella Infections in Interleukin-12 Receptor-Deficient Patients

1998 • 812 citations

Effects of Single-Dose Interleukin-12 Exposure on Interleukin-12–Associated Toxicity and Interferon-γ Production

1997 • 788 citations

A Controlled Trial of Interferon Gamma to Prevent Infection in Chronic Granulomatous Disease

1991 • 785 citations

Infection withMycobacterium aviumComplex in Patients without Predisposing Conditions

1989 • 701 citations

Thalidomide Costimulates Primary Human T Lymphocytes, Preferentially Inducing Proliferation, Cytokine Production, and Cytotoxic Responses in the CD8+ Subset

1998 • 576 citations

A human IFNGR1 small deletion hotspot associated with dominant susceptibility to mycobacterial infection

1999 • 483 citations

In vitroproduction of IFN-γ correlates with CA repeat polymorphism in the human IFN-γ gene

1999 • 465 citations

Mutation in the signal-transducing chain of the interferon-gamma receptor and susceptibility to mycobacterial infection.

1998 • 427 citations

Inherited interleukin 12 deficiency in a child with bacille Calmette-Guérin and Salmonella enteritidis disseminated infection.

1998 • 405 citations

Mycobacterium avium Complex Pulmonary Disease Presenting as an Isolated Lingular or Middle Lobe Pattern

1992 • 384 citations

Partial interferon-gamma receptor 1 deficiency in a child with tuberculoid bacillus Calmette-Guérin infection and a sibling with clinical tuberculosis.

1997 • 383 citations

The Influence of Thalidomide on the Clinical and Immunologic Manifestation of Erythema Nodosum Leprosum

1993 • 379 citations

Mice that lack the interferon-gamma receptor have profoundly altered responses to infection with Bacillus Calmette-Guérin and subsequent challenge with lipopolysaccharide.

1993 • 352 citations

Early interleukin 12 production by macrophages in response to mycobacterial infection depends on interferon gamma and tumor necrosis factor alpha.

1995 • 348 citations

Interferons Regulate the Phenotype of Wild-type and Mutant Herpes Simplex Viruses In Vivo

1999 • 343 citations

Local and Systemic Effects of Intradermal Recombinant Interferon-γ in Patients with Lepromatous Leprosy

1986 • 328 citations

Interferon-γ and interleukin-12 pathway defects and human disease

2000 • 326 citations

Gamma interferon activates human macrophages to become tumoricidal and leishmanicidal but enhances replication of macrophage-associated mycobacteria

1985 • 315 citations

Treatment of Refractory Disseminated Nontuberculous Mycobacterial Infection With Interferon Gamma: A Preliminary Report

1994 • 297 citations

Disseminated Infection with Mycobacterium avium-intracellulare

1985 • 293 citations

Familial disseminated atypical mycobacterial infection in childhood: a human mycobacterial susceptibility gene?

1995 • 217 citations

Interferon γ Regulates Acute and Latent Murine Cytomegalovirus Infection and Chronic Disease of the Great Vessels

1998 • 210 citations

Comparison of the roles of reactive oxygen and nitrogen intermediates in the host response to Mycobacterium tuberculosis using transgenic mice

1997 • 184 citations

Transient Loss of Resistance to Pulmonary Tuberculosis in p47^phox−/−Mice

2000 • 182 citations

Partial Interferon‐γ Receptor Signaling Chain Deficiency in a Patient with Bacille Calmette‐Guérin andMycobacterium abscessusInfection

2000 • 178 citations

Pectus Excavatum and Scoliosis: Thoracic Anomalies Associated with Pulmonary Disease Caused byMycobacterium aviumComplex

1991 • 175 citations

Defective monocyte costimulation for IFN-gamma production in familial disseminated Mycobacterium avium complex infection: abnormal IL-12 regulation.

1996 • 174 citations

Studies of IFN-Induced Transcriptional Activation Uncover the Jak-Stat Pathway

1998 • 173 citations

Viral infections in interferon-γ receptor deficiency

1999 • 173 citations

Polyclonal Mycobacterium avium Complex Infections in Patients with Nodular Bronchiectasis

1998 • 166 citations

Prolonged treatment with recombinant interferon gamma induces erythema nodosum leprosum in lepromatous leprosy patients.

1992 • 160 citations

Interleukin-12 production by human monocytes infected with Mycobacterium tuberculosis: role of phagocytosis

1996 • 159 citations

Abnormal Regulation of Interferon‐γ, Interleukin‐12, and Tumor Necrosis Factor‐α in Human Interferon‐g Receptor 1 Deficiency

1998 • 150 citations

Successful Treatment of Invasive Aspergillosis in Chronic Granulomatous Disease by Bone Marrow Transplantation, Granulocyte Colony-Stimulating Factor–Mobilized Granulocytes, and Liposomal Amphotericin-B

1998 • 147 citations

Chronic infection due to Mycobacterium intracellulare in mice: association with macrophage release of prostaglandin E2 and reversal by injection of indomethacin, muramyl dipeptide, or interferon-gamma.

1986 • 145 citations

CORRELATION OF GRANULOMA STRUCTURE WITH CLINICAL OUTCOME DEFINES TWO TYPES OF IDIOPATHIC DISSEMINATED BCG INFECTION

1997 • 135 citations

Detection of Intracellular Phosphorylated STAT-1 by Flow Cytometry

1999 • 127 citations

Interferon-γ in the Management of Infectious Diseases

1995 • 124 citations

Mendelian susceptibility to mycobacterial infection in man

1998 • 121 citations

Interferon-γ in the Management of Infectious Diseases

1995 • 114 citations

Defects in cell-mediated immunity affect chronic, but not innate, resistance of mice to Mycobacterium avium infection.

1997 • 113 citations

Interleukin-12: Basic Principles and Clinical Applications

1999 • 111 citations

Detection of Intracellular Phosphorylated STAT-4 by Flow Cytometry

2001 • 103 citations

Effector mechanisms involved in cytokine-mediated bacteriostasis of Mycobacterium avium infections in murine macrophages.

1993 • 101 citations

Once Weekly Azithromycin Therapy for Prevention ofMycobacterium aviumComplex Infection in Patients with AIDS: A Randomized, Double‐Blind, Placebo‐Controlled Multicenter Trial

1998 • 87 citations

Interleukin-12-stimulated natural killer cells can activate human macrophages to inhibit growth of Mycobacterium avium

1995 • 84 citations

Cytokine modulation of mycobacterium tuberculosis growth in human macrophages

1990 • 67 citations

Old mice are able to control low-dose aerogenic infections with Mycobacterium tuberculosis

1995 • 67 citations

Stimulation with cytokines enhances penetration of azithromycin into human macrophages

1991 • 64 citations

Safety and Effectiveness of Long-Term Interferon Gamma Therapy in Patients with Chronic Granulomatous Disease

1995 • 63 citations

Interferon- and Mycobacterium avium-intracellulare Infection

1989 • 55 citations

Oxidative and non-oxidative intracellular killing of Mycobacterium avium complex

1989 • 51 citations

Inhibition of cellular responsiveness to interferon-gamma (IFN gamma) induced by overexpression of inactive forms of the IFN gamma receptor

1993 • 51 citations

IL-12-Independent Costimulation Pathways for Interferon-γ Production in Familial DisseminatedMycobacterium aviumComplex Infection

1999 • 34 citations

Defective antigen processing associated with familial disseminated mycobacteriosis

1996 • 31 citations

Interferon-gamma receptor deficiency: relationship between genotype, environment, and phenotype (Review).

1998 • 28 citations

Nontuberculous mycobacterial pulmonary disease.

1998 • 26 citations

New developments in the treatment of nontuberculous mycobacterial (NTM) disease.

1996 • 24 citations

Isolated cutaneous response to granulocyte-monocyte colony stimulating factor in fatal idiopathic disseminated Bacillus-Calmette-Guerin infection

2000 • 16 citations

Effect of rhuIFN-gamma treatment in multibacillary leprosy patients.

1996 • 12 citations

Global Tuberculosis Challenges

1998 • 11 citations

Association for Patient-Oriented Research

1999 • 2 citations