A cluster of four Sp1 binding sites required for efficient expression of the human insulin receptor gene

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

1985 • 2,257 citations

Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain

1987 • 1,640 citations

The human insulin receptor cDNA: The structural basis for hormone-activated transmembrane signalling

1985 • 1,485 citations

The promoter-specific transcription factor Sp1 binds to upstream sequences in the SV40 early promoter

1983 • 1,471 citations

Tissue-specific in vitro transcription from the mouse albumin promoter

1986 • 1,322 citations

Insulin-Dependent Regulation of Insulin Receptor Concentrations: A Direct Demonstration in Cell Culture

1974 • 1,037 citations

A cDNA cloning vector that permits expression of cDNA inserts in mammalian cells.

1983 • 933 citations

After Insulin Binds

1987 • 687 citations

Human insulin receptors mutated at the ATP-binding site lack protein tyrosine kinase activity and fail to mediate postreceptor effects of insulin.

1987 • 648 citations

Receptor and postreceptor defects contribute to the insulin resistance in noninsulin-dependent diabetes mellitus.

1981 • 628 citations

Nucleoprotein complexes that regulate gene expression in adipocyte differentiation: direct participation of c-fos

1987 • 523 citations

The Molecular Mechanism of Insulin Action

1985 • 424 citations

Insulin Receptor: Evidence That It Is a Protein Kinase

1983 • 413 citations

Replacement of lysine residue 1030 in the putative ATP-binding region of the insulin receptor abolishes insulin- and antibody-stimulated glucose uptake and receptor kinase activity.

1987 • 399 citations

Structure of the human insulin receptor gene and characterization of its promoter.

1989 • 349 citations

Tyrosine-specific protein kinase activity is associated with the purified insulin receptor.

1983 • 324 citations

The Nature and Regulation of the Insulin Receptor: Structure and Function

1985 • 318 citations

Two Mutant Alleles of the Insulin Receptor Gene in a Patient with Extreme Insulin Resistance

1988 • 308 citations

Molecular cloning and characterization of a human DNA binding factor that represses transcription

1989 • 285 citations

Insulin-Resistant Diabetes Due to a Point Mutation That Prevents Insulin Proreceptor Processing

1988 • 253 citations

Acute insulin action requires insulin receptor kinase activity: introduction of an inhibitory monoclonal antibody into mammalian cells blocks the rapid effects of insulin.

1987 • 221 citations

Insulin-induced receptor loss in cultured human lymphocytes is due to accelerated receptor degradation.

1981 • 217 citations

Human Diabetes Associated with a Mutation in the Tyrosine Kinase Domain of the Insulin Receptor

1989 • 192 citations

Sequence-specific interactions between cellular DNA-binding proteins and the adenovirus origin of DNA replication.

1987 • 169 citations

The Insulin Receptor in Vertebrates Is Functionally More Conserved during Evolution than Insulin Itself

1979 • 164 citations

A mutation in the insulin receptor gene that impairs transport of the receptor to the plasma membrane and causes insulin-resistant diabetes.

1989 • 155 citations

Internalized insulin receptors are recycled to the cell surface in rat hepatocytes.

1982 • 142 citations

Human Diabetes Associated with a Deletion of the Tyrosine Kinase Domain of the Insulin Receptor

1989 • 129 citations

Isolation of a Drosophila genomic sequence homologous to the kinase domain of the human insulin receptor and detection of the phosphorylated Drosophila receptor with an anti-peptide antibody.

1986 • 123 citations

Characterization of the promoter region of the human insulin receptor gene. Evidence for promoter activity.

1987 • 117 citations

Mineral Metabolism and Bone Mass at Peripheral and Axial Skeleton in Diabetes Mellitus

1988 • 109 citations

A transcription factor active on the epidermal growth factor receptor gene.

1988 • 102 citations

Trans effect of the E1 region of adenoviruses on the expression of a prokaryotic gene in mammalian cells: resistance to 5' -CCGG- 3' methylation.

1986 • 79 citations

A leucine-to-proline mutation in the insulin receptor in a family with insulin resistance.

1989 • 77 citations

pSV00CAT: low background CAT plasmid

1988 • 75 citations

Characterization of the Promoter Region and 3′ End of the Human Insulin Receptor Gene

1989 • 74 citations

Insulin-resistant diabetes associated with partial deletion of insulin-receptor gene

1990 • 73 citations

Cloning of a drosophila cDNA encoding a polypeptide similar to the human insulin receptor precursor

1986 • 73 citations

Sequence and Analysis of Promoter Region of Human Insulin-Receptor Gene

1988 • 51 citations

Promoter and 11-kilobase upstream enhancer elements responsible for hepatoma cell-specific expression of the rat ornithine transcarbamylase gene.

1990 • 51 citations

Insulin resistance by unprocessed insulin proreceptors point mutation at the cleavage site

1988 • 46 citations

Defects in Human Insulin Receptor Gene Expression

1988 • 44 citations

Characterization of the mouse insulin receptor gene promoter.

1989 • 28 citations