Hepatitis B Virus Infection, the Immune Response and Hepatocellular Carcinoma

HEPATOCELLULAR CARCINOMA AND HEPATITIS B VIRUS

1981 • 2,891 citations

HBx gene of hepatitis B virus induces liver cancer in transgenic mice

1991 • 1,155 citations

Vaccine-induced escape mutant of hepatitis B virus

1990 • 1,081 citations

Vertical Transmission of Hepatitis B Antigen in Taiwan

1975 • 1,022 citations

Large surface proteins of hepatitis B virus containing the pre-s sequence

1984 • 812 citations

Viruses in Human Cancers

1991 • 793 citations

Integration of Hepatitis B Virus DNA into the Genome of Liver Cells in Chronic Liver Disease and Hepatocellular Carcinoma

1981 • 715 citations

Molecular pathogenesis of hepatocellular carcinoma in hepatitis B virus transgenic mice

1989 • 692 citations

Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinoma

1990 • 660 citations

A virus similar to human hepatitis B virus associated with hepatitis and hepatoma in woodchucks.

1978 • 657 citations

Presence of integrated hepatitis B virus DNA sequences in cellular DNA of human hepatocellular carcinoma

1980 • 610 citations

Hepatocellular carcinoma and the hepatitis B virus: evidence for a causal association.

1978 • 588 citations

Is a function of the secreted hepatitis B e antigen to induce immunologic tolerance in utero?

1990 • 578 citations

Cellular immune response to hepatitis B virus-encoded antigens in acute and chronic hepatitis B virus infection.

1990 • 503 citations

Mechanisms of class I restricted immunopathology. A transgenic mouse model of fulminant hepatitis.

1993 • 454 citations

Long-Term Remission of Chronic Hepatitis B after Alpha-Interferon Therapy

1991 • 415 citations

Hepatitis B virus DNA integration in a sequence homologous to v-erb-A and steroid receptor genes in a hepatocellular carcinoma

1986 • 399 citations

Specificity of T lymphocyte cytotoxicity to autologous hepatocytes in chronic hepatitis B virus infection: evidence that T cells are directed against HBV core antigen expressed on hepatocytes.

1982 • 395 citations

Immunobiology and Pathogenesis of Hepatocellular Injury in Hepatitis B Virus Transgenic Mice

1990 • 363 citations

Cytotoxic T lymphocytes recognize an HLA-A2-restricted epitope within the hepatitis B virus nucleocapsid antigen.

1991 • 363 citations

HLA A2 restricted cytotoxic T lymphocyte responses to multiple hepatitis B surface antigen epitopes during hepatitis B virus infection.

1993 • 333 citations

Antibody production to the nucleocapsid and envelope of the hepatitis B virus primed by a single synthetic T cell site

1987 • 319 citations

Acute exacerbations of chronic type B hepatitis are accompanied by increased T cell responses to hepatitis B core and e antigens. Implications for hepatitis B e antigen seroconversion.

1992 • 294 citations

The preS2/S region of integrated hepatitis B virus DNA encodes a transcriptional transactivator

1990 • 284 citations

A novel steroid thyroid hormone receptor-related gene inappropriately expressed in human hepatocellular carcinoma

1987 • 282 citations

A Transgenic Mouse Model of the Chronic Hepatitis B Surface Antigen Carrier State

1985 • 281 citations

Transcriptional trans-activating function of hepatitis B virus

1987 • 280 citations

Hepatocarcinogenicity of the woodchuck hepatitis virus.

1987 • 273 citations

Relationship Between Hepatocellular Carcinoma and Cirrhosis

1984 • 264 citations

Frequent activation of N-myc genes by hepadnavirus insertion in woodchuck liver tumours

1990 • 245 citations

Identification of integrated hepatitis B virus DNA sequences in human hepatocellular carcinomas

1981 • 217 citations

The mode of hepatitis B virus DNA integration in chromosomes of human hepatocellular carcinoma.

1987 • 204 citations

Hepatocellular Carcinoma and Hepatitis B Virus

1984 • 202 citations

Deletion in Chromosome 11p Associated with a Hepatitis B Integration Site in Hepatocellular Carcinoma

1985 • 199 citations

Hepatitis B virus transactivator X protein is not tumorigenic in transgenic mice

1990 • 196 citations

Preferential activation of Th2 cells in chronic graft-versus-host reaction.

1993 • 187 citations

Relation of the hepatitis B virus carrier state to hepatocellular carcinoma

1987 • 186 citations

The serology of chronic hepatitis B infection revisited.

1993 • 165 citations

Expression of hepatitis B virus surface and core antigens: influences of pre-S and precore sequences

1987 • 165 citations

The HBV X-ORF encodes a transactivator: a potential factor in viral hepatocarcinogenesis.

1988 • 161 citations

Hepatitis B virus integration site in hepatocellular carcinoma at chromosome 17;18 translocation.

1986 • 155 citations

Rearrangement and enhanced expression of c-myc in hepatocellular carcinoma of hepatitis virus infected woodchucks

1986 • 139 citations

Hepatitis B and C viruses in the development of hepatocellular carcinoma

1994 • 138 citations

Hepatitis B virus integration event in human chromosome 17p near the p53 gene identifies the region of the chromosome commonly deleted in virus-positive hepatocellular carcinomas.

1991 • 128 citations

Hepatocellular carcinoma in ground squirrels persistently infected with ground squirrel hepatitis virus.

1986 • 126 citations

Hepatitis B Virus Infection and Primary Hepatocellular Carcinoma 2 3

1977 • 125 citations

Cloning and structural analysis of integrated woodchuck hepatitis virus sequences from hepatocellular carcinomas of woodchucks

1982 • 125 citations

Comparative immunogenicity of hepatitis B virus core and E antigens.

1988 • 117 citations

Chromosomal translocation and inverted duplication associated with integrated hepatitis B virus in hepatocellular carcinomas

1987 • 113 citations

Hepatitis B virus integration in hepatocellular carcinoma DNA: duplication of cellular flanking sequences at the integration site.

1985 • 112 citations

Hepatitis B Virus Mutants with Precore-Region Defects in Two Babies with Fulminant Hepatitis and Their Mothers Positive for Antibody to Hepatitis B e Antigen

1991 • 105 citations

Detection of Hepatitis B Virus DNA in Hepatocellular Carcinomas in Japan

1984 • 102 citations

Assembly of viral particles in Xenopus oocytes: pre-surface-antigens regulate secretion of the hepatitis B viral surface envelope particle.

1986 • 98 citations

Hepatitis B virus large surface protein is not secreted but is immunogenic when selectively expressed by recombinant vaccinia virus

1986 • 98 citations

Serology of acute exacerbation in chronic hepatitis B virus infection

1993 • 96 citations

Hepatitis B Vaccines in Clinical Practice

1993 • 96 citations

Duck hepatitis B virus and liver diseases

1983 • 88 citations

Distinguishing between acute and symptomatic chronic hepatitis B virus infection

1994 • 77 citations

Contribution of aflatoxin B1 and hepatitis B virus infection in the induction of liver tumors in ducks.

1990 • 76 citations

Immune Response to Hepatitis B Virus Proteins: Relevance of the Murine Model

1991 • 75 citations

Cloning and analysis of integrated hepatitis virus sequences from a human hepatoma cell line

1984 • 75 citations

Structural rearrangement of integrated hepatitis B virus DNA as well as cellular flanking DNA is present in chronically infected hepatic tissues

1990 • 74 citations

Cellular and Molecular Mechanisms of Hepatocarcinogenesis

1992 • 67 citations

Co-amplification of integrated hepatitis B virus DNA and transforming gene hst-1 in a hepatocellular carcinoma.

1988 • 65 citations

Structural analysis of a hepatitis B virus genome integrated into chromosome 17p of a human hepatocellular carcinoma

1988 • 59 citations

Hepatic neoplasms in aflatoxin B1-treated, congenital duck hepatitis B virus-infected, and virus-free pekin ducks.

1990 • 49 citations

VIRUS AND IMMUNE RESPONSES: LYMPHOCYTIC CHORIOMENINGITIS VIRUS AS A PROTOTYPE MODEL OF VIRAL PATHOGENESIS

1985 • 47 citations

Maternofetal Transmission of IgG-Bound Hepatitis B e Antigen

1982 • 42 citations

Hepatitis B Viral DNA in Infected Human Liver and in Hepatocellular Carcinoma

1985 • 39 citations

Incidence and nature of cytoplasmic hepatitis B antigen in hepatocytes.

1975 • 39 citations

A chromosome 17:7 translocation is associated with a hepatitis B virus DNA integration in human hepatocellular carcinoma DNA

1992 • 38 citations

A lack of direct role of hepatitis B virus in the activation of ras and c-myc oncogenes in human hepatocellular carcinogenesis

1988 • 31 citations

Status of hepatitis B virus DNA in hepatocellular carcinoma: A study based on paired tumor and nontumor liver tissues

1988 • 27 citations

A Comparison of the Molecular Structure of Integrated Hepatitis B Virus Genomes in Hepatocellular Carcinoma Cells and Hepatocytes Derived From the Same Patient

1990 • 19 citations

Hepatocellular Carcinoma

1983 • 9 citations

Historic milestones in cancer virology.

1979 • 7 citations