A Comparison of the Molecular Structure of Integrated Hepatitis B Virus Genomes in Hepatocellular Carcinoma Cells and Hepatocytes Derived From the Same Patient

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

[2] New M13 vectors for cloning

1983 • 5,402 citations

Screening λgt Recombinant Clones by Hybridization to Single Plaques in Situ

1977 • 4,696 citations

Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate.

1979 • 3,525 citations

Viral Hepatitis and Liver Disease

1985 • 1,886 citations

Lambda replacement vectors carrying polylinker sequences

1983 • 1,809 citations

The hepatitis B virus

1985 • 1,219 citations

Epidemiology of Hepatocellular Carcinoma

2005 • 1,146 citations

Lambdoid phages that simplify the recovery of in vitro recombinants

1977 • 779 citations

Integration of Hepatitis B Virus DNA into the Genome of Liver Cells in Chronic Liver Disease and Hepatocellular Carcinoma

1981 • 715 citations

Hierarchical order in chromosome-specific human alpha satellite DNA

1987 • 510 citations

Tbe complete nudeotide sequences of the cloned hepatitis B vims DNA; subtype adr and adw

1983 • 426 citations

Viral Hepatitis and Liver Disease

1989 • 389 citations

State of hepatitis B virus DNA in hepatocytes of patients with hepatitis B surface antigen-positive and -negative liver diseases.

1981 • 351 citations

Packaging recombinant DNA molecules into bacteriophage particles in vitro.

1977 • 343 citations

Cloning and structural analyses of hepatitis B virus DNAs, subtypeadr

1983 • 309 citations

Sequence definition and organization of a human repeated DNA

1980 • 230 citations

The mode of hepatitis B virus DNA integration in chromosomes of human hepatocellular carcinoma.

1987 • 204 citations

Deletion in Chromosome 11p Associated with a Hepatitis B Integration Site in Hepatocellular Carcinoma

1985 • 199 citations

Complete nucleotide sequence of hepatitis B virus DNA of subtype adr and its conserved gene organization

1984 • 196 citations

Antibodies to Peptides Detect New Hepatitis B Antigen: Serological Correlation with Hepatocellular Carcinoma

1985 • 169 citations

Specific hepatitis B virus integration in hepatocellular carcinoma DNA through a viral 11-base-pair direct repeat.

1984 • 156 citations

Hepatitis B virus integration site in hepatocellular carcinoma at chromosome 17;18 translocation.

1986 • 155 citations

Effect of chromosomal position on amplification of transfected genes in animal cells

1984 • 140 citations

Multiple integration site of hepatitis B virus DNA in hepatocellular carcinoma and chronic active hepatitis tissues from children

1987 • 118 citations

Sequence of hepatitis B virus DNA incorporated into the genome of a human hepatoma cell line

1985 • 113 citations

Chromosomal translocation and inverted duplication associated with integrated hepatitis B virus in hepatocellular carcinomas

1987 • 113 citations

Hepatitis B virus integration in hepatocellular carcinoma DNA: duplication of cellular flanking sequences at the integration site.

1985 • 112 citations

Repeating restriction fragments of human DNA

1976 • 90 citations

Inversely repeating integrated hepatitis B virus DNA and cellular flanking sequences in the human hepatoma-derived cell line huSP.

1985 • 86 citations

Tight clustering of human hepatitis B virus integration sites in hepatomas near a triple-stranded region

1987 • 86 citations

Toward a molecular paleontology of primate genomes

1981 • 68 citations

Amplification and rearrangement in hepatoma cell DNA associated with integrated hepatitis B virus DNA.

1984 • 60 citations

Integration of hepatitis B virus DNA in chromosome-specific satellite sequences

1986 • 51 citations

The genetic organization of integrated hepatitis B virus DNA in the human hepatoma cell line PLC/PRF/5

1984 • 51 citations

High frequency DNA rearrangements associated with mouse centromeric satellite DNA

1986 • 46 citations

Hepatitis B Viral DNA in Infected Human Liver and in Hepatocellular Carcinoma

1985 • 39 citations

Integration of hepatitis B virus: analysis of unoccupied sites

1987 • 31 citations

Induction of Hepatitis B Virus Core Gene in Human Cells by Cytosine Demethylation in the Promoter

1985 • 28 citations

Free and integrated forms of hepatitis B virus DNA in human hepatocellular carcinoma cells (PLC/342) propagated in nude mice

1987 • 21 citations