The contribution of proximity and orientation to catalytic reaction rates

Statistical mechanics of chain molecules

1969 • 6,455 citations

Structure of Hen Egg-White Lysozyme: A Three-dimensional Fourier Synthesis at 2 Å Resolution

1965 • 1,623 citations

Entropic Contributions to Rate Accelerations in Enzymic and Intramolecular Reactions and the Chelate Effect

1971 • 980 citations

Mechanism and Structure in Organic Chemistry.

1960 • 590 citations

The Effect of Geminal Substitution Ring Size and Rotamer Distribution on the Intramolecular Nucleophilic Catalysis of the Hydrolysis of Monophenyl Esters of Dibasic Acids and the Solvolysis of the Intermediate Anhydrides

1960 • 209 citations

A Source for the Special Catalytic Power of Enzymes: Orbital Steering

1970 • 153 citations

INTRAMOLECULAR MODELS DEPICTING THE KINETIC IMPORTANCE OF „FIT” IN ENZYMATIC CATALYSIS

1960 • 107 citations

The Active Site and Enzyme Action

1960 • 102 citations

The Compensation in ΔH[UNK] and ΔS[UNK] Accompanying the Conversion of Lower Order Nucleophilic Displacement Reactions to Higher Order Catalytic Processes. The Temperature Dependence of the Hydrazinolysis and Imidazole-Catalyzed Hydrolysis of Substituted Phenyl Acetates

1964 • 97 citations

Properties of Thiol-Subtilisin

1968 • 80 citations

The comparison of non-enzymic and enzymic reaction velocities

1962 • 80 citations

Prediction of RNA Secondary Structure

1971 • 78 citations

A Comparison of the Bimolecular and Intramolecular Nucleophilic Catalysis of the Hydrolysis of Substituted Phenyl Acylates by the Dimethylamino Group

1963 • 74 citations

The dipole moments and the structure of polyoxymethylene dimethyl ethers

1956 • 72 citations

Theoretical Aspects of Orbital Steering

1971 • 63 citations

On the Concept of Orbital Steering in Catalytic Reactions

1971 • 62 citations

Imidazole Catalysis. V. The Intramolecular Participation of the Imidazolyl Group in the Hydrolysis of Some Esters and the Amide of γ-(4-Imidazolyl)-butyric Acid and 4-(2'-Acetoxyethyl)-imidazole²

1959 • 57 citations

Significance of Molecular Alignment and Orbital Steering in Mechanisms for Enzymatic Catalysis

1972 • 56 citations

Environment of a reporter group at the active site of chymotrypsin

1967 • 44 citations

Theory of the influence of oligonucleotide chain conformation on double helix stability

1971 • 36 citations

Steric Acceleration of the Lactonization of 2-(Hydroxymethyl)benzoic Acids^1,2

1965 • 21 citations

Electrostatic contributions to oligonucleotide transitions

1971 • 18 citations

The gem effect. IV. Activation parameters accompanying the increased steric requirements of 3,3'-substituents in the solvolysis of mono(p-bromophenyl) glutarates

1968 • 17 citations