Acceleration of reactions by enzymes

Some Factors in the Interpretation of Protein Denaturation

1959 • 4,817 citations

Theoretical studies of enzymic reactions: Dielectric, electrostatic and steric stabilization of the carbonium ion in the reaction of lysozyme

1976 • 4,264 citations

Enthalpy–entropy compensation phenomena in water solutions of proteins and small molecules: A ubiquitous properly of water

1970 • 1,173 citations

Heat capacity and entropy changes in processes involving proteins.

1977 • 846 citations

Structural basis of the activation and action of trypsin

1978 • 669 citations

Nature of Forces between Large Molecules of Biological Interest*

1948 • 514 citations

Energetics of enzyme catalysis.

1978 • 468 citations

TRANSITION STATE ANALOG INHIBITORS AND ENZYME CATALYSIS

1976 • 415 citations

Transition State Analogues for Enzyme Catalysis

1969 • 381 citations

Metal .sigma.-hydrocarbyls, MRn. Stoichiometry, structures, stabilities, and thermal decomposition pathways

1976 • 337 citations

INTERMOLECULAR CROSS LINKING OF A PROTEIN IN THE CRYSTALLINE STATE: CARBOXYPEPTIDASE-A

1964 • 287 citations

.sigma.-Alkyl and -aryl complexes of the group 4-7 transition metals

1976 • 257 citations

Structures of product and inhibitor complexes of Streptomyces griseus protease A at 1.8 Å resolution

1980 • 214 citations

The Enzymic Behavior of Carboxypeptidase-A in the Solid State^*

1966 • 210 citations

The Effect of Geminal Substitution Ring Size and Rotamer Distribution on the Intramolecular Nucleophilic Catalysis of the Hydrolysis of Monophenyl Esters of Dibasic Acids and the Solvolysis of the Intermediate Anhydrides

1960 • 209 citations

A phosphonamidate dipeptide analog as an inhibitor of carboxypeptidase A

1981 • 208 citations

Binding of the by-product analog benzylsuccinic acid by carboxypeptidase A

1973 • 193 citations

On the size of the active site in proteases II. Carboxypeptidase-A

1967 • 152 citations

Carboxypeptidase A. Differences in the mechanisms of ester and peptide hydrolysis

1974 • 148 citations

Mechanisms of thiamine-catalyzed reactions. Decarboxylation of 2-(1-carboxy-l-hydroxyethyl)-3,4-dimethylthiazolium chloride

1970 • 135 citations

THE STRUCTURE OF CARBOXYPEPTIDASE A, VI. SOME RESULTS AT 2.0-Å RESOLUTION, AND THE COMPLEX WITH GLYCYL-TYROSINE AT 2.8-Å RESOLUTION

1967 • 126 citations

Design of potent and specific inhibitors of carboxypeptidases A and B

1979 • 117 citations

Entropy, Binding Energy, and Enzymic Catalysis

1977 • 114 citations

On the Stability of Metallo-Organic Compounds

1953 • 113 citations

Reporter group at the active site of acetoacetate decarboxylase. II. Ionization constant of the amino group

1971 • 108 citations

Catalytic role of the metal ion of carboxypeptidase A in ester hydrolysis.

1979 • 104 citations

Remarkable stereoselectivity in the hydrolysis of dioxolenium ions and orthoesters fused to anchored six-membered rings

1970 • 99 citations

Modification of carboxyl groups in bovine carboxypeptidase A. I. Inactivation of the enzyme by N-ethyl-5-phenylisoxazolium-3'-sulfonate (Woodward's reagent K)

1971 • 98 citations

Protein hydration changes during catalysis: a new mechanism of enzymic rate-enhancement and ion activation/inhibition of catalysis.

1975 • 92 citations

ON THE MECHANISM OF THE ENZYMATIC DECARBOXYLATION OF ACETOACETATE¹

1959 • 91 citations

The Functional Tyrosyl Residues of Carboxypeptidase A. Nitration with Tetranitromethane^*

1967 • 86 citations

Unified picture of mechanisms of catalysis by carboxypeptidase A.

1977 • 83 citations

Organo-transition-metal complexes: stability, reactivity and orbital correlations

1973 • 79 citations

A model for substrate binding and kinetics of carboxypeptidase A

1968 • 72 citations

Reporter group at the active site of acetoacetate decarboxylase. I. Ionization constant of the nitrophenol

1971 • 71 citations

Calorimetric investigation of inhibitor binding to rabbit muscle aldolase

1971 • 68 citations

Mechanism of action of carboxypeptidase A in ester hydrolysis.

1976 • 66 citations

Rapid amide hydrolysis mediated by copper and zinc

1979 • 66 citations

Environment and conformation dependent sensitivity of the arsanilazotyrosine-248 carboxypeptidase A chromophore

1975 • 64 citations

Binding of ligands to the active site of carboxypeptidase A.

1981 • 57 citations

The transition metal to carbon sigma bond

1972 • 56 citations

Structure of the potato inhibitor complex of carboxypeptidase A at 2.5-A resolution.

1980 • 53 citations

Hydrolysis of esters by carboxypeptidase A requires a penta-coordinate metal ion.

1982 • 49 citations

The importance of the conformation of the tetrahedral intermediate for the α‐chymotrypsin‐catalyzed hydrolysis of peptide substrates

1975 • 47 citations

Kinetic properties of crystalline enzymes. Carboxypeptidase A

1977 • 47 citations

On the mechanism of catalysis by carboxypeptidase A

1976 • 45 citations

Similarities Between the Conformation of Arsanilazotyrosine 248 of Carboxypeptidase A _α in the Crystalline State and in Solution

1972 • 44 citations

Modification of carboxyl groups in bovine carboxypeptidase A. II. Chemical identification of a functional glutamic acid residue and other reactive groups.

1971 • 42 citations

Structure of an actively exchanging complex between carboxypeptidase A and a substrate analogue.

1980 • 31 citations

S_N1 hydrolyses of glycosyl pyridinium salts, and quantification of the main source of catalytic power of E. coli(lacZ)-β-galactosidase

1977 • 28 citations

The Physical State Dependence of Carboxypeptidase A _α and A _γ Kinetics

1974 • 28 citations

Differences between the conformations of nitrotyrosyl-248 carboxypeptidase A in the crystalline state and in solution

1974 • 26 citations

Solvation and approximation. Solvent effects on the bimolecular and intramolecular nucleophilic attack of carboxyl anion on phenyl esters

1970 • 23 citations

Functional tyrosyl residues of carboxypeptidase A. The effect of protein structure on the reactivity of tyrosine-198

1978 • 23 citations

Multiple inhibitor binding to arsanilazotyrosine-248 carboxypeptidase A

1978 • 21 citations

Intramolecular electrostatic and general acid catalysis in the hydrolysis of O,S-thioacetals

1980 • 21 citations

Transition states, standard states and enzymic catalysis

1980 • 18 citations

Mapping Toe Active Site of Carboxypeptidase‐A: A Proposed Scheme for Substrate Binding at the Active Site

1974 • 15 citations

Entropy contributions to rate accelerations of intramolecular reactions in water VS non-structured solvents

1973 • 12 citations

Chapter 26. Selective Enzyme Inhibitors in Medicinal Chemistry

1978 • 7 citations