Aging, Longevity, and Cancer: Studies in Down's Syndrome and Centenarians^a

Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome

1985 • 1,125 citations

A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility.

1988 • 958 citations

Oxidative damage to DNA: relation to species metabolic rate and life span.

1988 • 587 citations

Ageing of Clones of Mammalian Cells

1973 • 409 citations

A test of evolutionary theories of senescence

1980 • 349 citations

Three Mutants That Extend Both Mean and Maximum Life Span of the Nematode, Caenorhabditis Elegans, Define the Age-1 Gene

1988 • 239 citations

The effect of donor age on spontaneous and induced micronuclei

1985 • 179 citations

DNA, mutations and aging

1989 • 158 citations

THYMIC HORMONE DEFICIENCY IN NORMAL AGEING AND DOWN'S SYNDROME: IS THERE A PRIMARY FAILURE OF THE THYMUS?

1984 • 157 citations

Extremely low frequency pulsed electromagnetic fields increase cell proliferation in lymphocytes from young and aged subjects

1989 • 149 citations

Cell proliferation, cell death and aging

1989 • 123 citations

Intrinsic mutagenesis

1974 • 122 citations

Extremely low frequency pulsed electromagnetic fields increase interleukin‐2 (IL‐2) utilization and IL‐2 receptor expression in mitogen‐stimulated human lymphocytes from old subjects

1989 • 121 citations

Precocious aging of the immune system in Down syndrome: Alteration of b lymphocytes, T-lymphocyte subsets, and cells with natural killer markers

2005 • 114 citations

Age-related expansion of functionally inefficient cells with markers of natural killer activity in Down's syndrome

1991 • 110 citations

Deficiency of autologous mixed lymphocyte reactions and serum thymic factor level in Down's syndrome.

1981 • 87 citations

Presence of ACTH and β-endorphin immunoreactive molecules in the freshwater snail Planorbarius corneus (L.) (Gastropoda, Pulmonata) and their possible role in phagocytosis

1990 • 85 citations

Immunoregulation in aging.

1987 • 76 citations

T AND B LYPMHOCYTE SUBPOPULATIONS IN DOWN'S SYNDROME. A STUDY ON NON‐INSTITUTIONALISED SUBJECTS

1978 • 54 citations

Minireview: What Evolutionary Biology Can Do for Gerontology

1989 • 52 citations

DNA sequence changes in aging: How frequent, how important?

1990 • 44 citations

Evolutionary Biology of Aging and Longevity in Mammalian Species

1984 • 39 citations

DNA repair after gamma radiation and superoxide dismutase activity in lymphocytes from subjects of far advanced age

1982 • 37 citations

Age-related increase of mitomycin C-induced micronuclei in lymphocytes from Down's syndrome subjects

1990 • 36 citations

Enhancing effect of lithium and potassium ions on lectin-induced lymphocyte proliferation in aging and down's syndrome subjects

1983 • 36 citations

Alterations of the Capping Phenomenon on Lymphocytes from Aged and Down’s Syndrome Subjects

1984 • 29 citations

Recovery of Human Lymphocytes Damaged with γ-Radiation or Enzymatically Produced Oxygen Radicals: Different Effects of Poly(ADP-ribosyl)polymerase Inhibitors

1990 • 25 citations

Genetic Specification of Life Span: Processes, Problems, and Potentials

1988 • 18 citations

Fetal thymic differentiation in Down's syndrome.

1989 • 17 citations

Defective Self-Recognition in Subjects of Far-Advanced Age

1983 • 13 citations

Oxidative Stress, Poly(ADP)Ribosylation and Aging: In Vitro Studies on Lymphocytes from Normal and Down’s Syndrome Subjects of Different Age and from Patients with Alzheimer’s Dementia

1990 • 12 citations

Effect of ADP‐Ribosyl Transferase Inhibitors on the Survival of Human Lymphocytes after Exposure to Different DNA‐Damaging Agents ^a

1988 • 7 citations