Modification of histidines in human prothrombin. Effect on the interaction of fibrinogen with thrombin from diethyl pyrocarbonate-modified prothrombin.

Application of a Theory of Enzyme Specificity to Protein Synthesis

1958 • 2,272 citations

Spectrophotometric Assay Using o-Phthaldialdehyde for Determination of Proteolysis in Milk and Isolated Milk Proteins

1983 • 1,431 citations

[41] Modification of histidyl residues in proteins by diethylpyrocarbonate

1977 • 813 citations

Inactivation of Myosin by 2,4-Dinitrophenol and Protection by Adenosine Triphosphate and Other Phosphate Compounds

1963 • 409 citations

Ethoxyformylation of proteins. Reaction of ethoxyformic anhydride with .alpha.-chymotrypsin, pepsin, and pancreatic ribonuclease at pH 4

1970 • 388 citations

Characterization of the complementary deoxyribonucleic acid and gene coding for human prothrombin

1983 • 299 citations

Comparative model-building of the mammalian serine proteases

1981 • 286 citations

A simple, specific one-stage prothrombin assay using Russell's viper venom in cephalin suspension.

1955 • 261 citations

Computer-generated models of blood coagulation factor Xa, factor IXa, and thrombin based upon structural homology with other serine proteases.

1982 • 220 citations

Evidence of an essential histidine residue in thermolysin

1974 • 210 citations

[13] Prothrombin

1976 • 197 citations

Ionic properties of an essential histidine residue in pig heart lactate dehydrogenase

1973 • 176 citations

Protein Shape and Biological Control

1973 • 103 citations

The Purification of Thrombin and Isolation of a Peptide Containing the Active Center Histidine

1971 • 101 citations

Chemical modification of bacterial luciferase with ethoxyformic anhydride: evidence for an essential histidyl residue

1976 • 92 citations

Effects of chemical modification on the activity of Crotalus adamanteus phospholipase A₂. Evidence for an essential amino group

1973 • 76 citations

Evidence for an essential histidine residue in S-adenosylhomocysteinase from rat liver

1983 • 66 citations

Covalent modification of human alpha-thrombin with pyridoxal 5'-phosphate. Effect of phosphopyridoxylation on the interaction of thrombin with heparin.

1979 • 63 citations

Protonic reorganization and substrate structure in catalysis by serine proteases

1980 • 62 citations

Tryptophan analysis of proteins in 6M guanidine hydrochloride: Modification for more general application

1974 • 51 citations

Correlations between biological activity and the number of functional groups chemically modified

1979 • 47 citations

The acetylation of thrombin.

1959 • 46 citations

[24] Prothrombin activator from Echis carinatus venom

1981 • 45 citations

The irreversible cleavage of histidine residues by diethylpyrocarbonate (ethoxyformic anhydride)

1976 • 42 citations

THE ACETYLATION OF THROMBIN

1959 • 37 citations

Decreased Heparin Sensitivity of Cyclohexanedione-Modified Thrombin

1978 • 31 citations

Reaction of purified bovine thrombin with N-acetylimidazole

1973 • 29 citations

Bovine alpha- and beta-thrombin. Reduced fibrinogen-clotting activity of beta-thrombin is not a consequence of reduced affinity for fibrinogen.

1984 • 25 citations

The modification of tryptophan in bovine thrombin

1977 • 24 citations

The differential effect of tetranitromethane on the proteinase and esterase activity of bovine thrombin

1971 • 24 citations

Nitration of Pepsin, Thrombin and Carboxypeptidase B with Tetranitromethane

1969 • 18 citations

Tyrosine and tryptophan residues and amino groups in thrombin related to enzymic activities

1970 • 16 citations

Inhibition of Hageman Factor, Plasma Thromboplastin Antecedent, Thrombin and Other Clotting Factors by Phenylglyoxal Hydrate

1975 • 7 citations

Reaction of bovine thrombin with N-butyrylimidazole. Two different reactions resulting in the inhibition of catalytic activity

1975 • 7 citations

Chemically modified bovine prothrombin as a substrate in studies of activation kinetics and fluorescence changes during thrombin formation.

1980 • 6 citations

Amidinated thrombin: Preparation and peptidase activity

1978 • 6 citations