Bovine alpha- and beta-thrombin. Reduced fibrinogen-clotting activity of beta-thrombin is not a consequence of reduced affinity for fibrinogen.

Serine Proteases: Structure and Mechanism of Catalysis

1977 • 1,238 citations

Role of a Buried Acid Group in the Mechanism of Action of Chymotrypsin

1969 • 1,060 citations

[41] Modification of histidyl residues in proteins by diethylpyrocarbonate

1977 • 813 citations

Human thrombins. Production, evaluation, and properties of alpha-thrombin.

1977 • 587 citations

Hemostasis and Thrombosis, Basic Principles and Clinical Practice

1983 • 450 citations

Comparison of the esterase activities of trypsin, plasmin, and thrombin on guanidinobenzoate esters. Titration of the enzymes

1969 • 433 citations

[28] Assay of coagulation proteases using peptide chromogenic and fluorogenic substrates

1981 • 310 citations

Chromatography of Trypsin and Its Derivatives

1968 • 281 citations

Rapid method for the purification of bovine thrombin and the inhibition of the purified enzyme with phenylmethylsulfonyl fluoride

1971 • 281 citations

Direct determination of the protonation states of aspartic acid-102 and histidine-57 in the tetrahedral intermediate of the serine proteases: neutron structure of trypsin

1981 • 266 citations

[14] Thrombin

1976 • 214 citations

Interactions of a fluorescent active-site-directed inhibitor of thrombin: dansylarginine N-(3-ethyl-1,5-pentanediyl)amide

1979 • 213 citations

Simultaneous Purification of Bovine Prothrombin and Factor X

1973 • 204 citations

Preparation and partial characterization of two forms of bovine thrombin

1975 • 183 citations

Ionic properties of an essential histidine residue in pig heart lactate dehydrogenase

1973 • 176 citations

The chemistry and physiology of human plasma proteins

1980 • 167 citations

Chemistry and Biology of Thrombin

1978 • 166 citations

Re-examination of the charge relay system in subtilisin comparison with other serine proteases.

1977 • 119 citations

Chemistry and biology of thrombin

1977 • 116 citations

Multiple Active Forms of Thrombin

1971 • 108 citations

The Purification of Thrombin and Isolation of a Peptide Containing the Active Center Histidine

1971 • 101 citations

Steady-state kinetic study of the bovine thrombin-fibrinogen interaction

1980 • 88 citations

Multiple Active Forms of Thrombin

1971 • 79 citations

Multiple Bovine Thrombin Components

1970 • 78 citations

Preparation and properties of thrombin

1968 • 70 citations

Antithrombin reactions with .alpha.- and .gamma.-thrombins

1979 • 69 citations

Protonic reorganization and substrate structure in catalysis by serine proteases

1980 • 62 citations

Human thrombin: Partial primary structure

1977 • 57 citations

Multiple Active Forms of Thrombin

1973 • 53 citations

The Conversion of Human Prothrombin to Thrombin by Sodium Citrate

1965 • 50 citations

Isolation and some properties of thrombin-E and other prothrombin derivatives

1974 • 49 citations

Role of Asp102 in the enzymatic reaction of bovine β-trypsin

1981 • 44 citations

The Molecular Weights of Bovine Thrombin and Its Primary Autolysis Products

1969 • 44 citations

Two Forms of Human Thrombin

1973 • 42 citations

Mechanism of action of thrombin on fibrinogen on the role of the a chain of bovine thrombin in specificity and in differentiating between thrombin and trypsin

1975 • 37 citations

Esterase and Clotting Activity Derived From Purified Prothrombin

1957 • 36 citations

Spin-labeled sulfonyl fluorides as active-site probes of protease structure. Part 3. Active-site topography of human coagulant (.alpha.) and noncoagulant (.gamma.)thrombins

1981 • 35 citations

Interaction of Soybean Trypsin Inhibitor with Thrombin and Its Effect on Prothrombin Activation

1969 • 32 citations

The covalent differences between bovine alpha- and beta-thrombin. A structural explanation for the changes in catalytic activity.

1979 • 24 citations

Stability differences between high coagulant (alpha) and noncoagulant (gamma) human thrombins. Denaturation.

1980 • 20 citations

Conformational differences between high clotting human .alpha.-thrombin and nonclotting .gamma.-thrombin

1981 • 20 citations

Solvent effects on the deacylation of acyl-chymotrypsins: a critical comment on the charge-relay hypothesis

1981 • 16 citations

Isolation and characterization of multiple forms of human thrombin

1974 • 15 citations

Comparison of the Catalytic Properties of Thrombin and Trypsin by Kinetic Analysis on the Basis of Active Enzyme Concentration1

1975 • 15 citations

The structure of human thrombin in relation to autolytic degradation

1976 • 13 citations

Conversion of Pig Prothrombin into Thrombin: Amino Acid Composition of the Active Enzyme

1974 • 11 citations

The chemical reactivity of the histidine-195 residue in lactate dehydrogenase thiomethylated at the cysteine-165 residue

1981 • 9 citations

On the Preparation of Bovine α-Thrombin

1978 • 8 citations

The role of the environment around the catalytic triad in β-trypsin: A molecular orbital study

1982 • 5 citations