Covalent modification of human alpha-thrombin with pyridoxal 5'-phosphate. Effect of phosphopyridoxylation on the interaction of thrombin with heparin.

The Purification and Mechanism of Action of Human Antithrombin-Heparin Cofactor

1973 • 1,363 citations

The separation of active and inactive forms of heparin

1976 • 494 citations

Preparation of Crystalline Phosphorylated Derivatives of Vitamin B₆

1954 • 473 citations

Anticoagulant activity of heparin: Separation of high‐activity and low‐activity heparin species by affinity chromatography on immobilized antithrombin

1976 • 420 citations

Inactivation of Myosin by 2,4-Dinitrophenol and Protection by Adenosine Triphosphate and Other Phosphate Compounds

1963 • 409 citations

[14] Thrombin

1976 • 214 citations

Binding of low-affinity and high-affinity heparin to antithrombin. Ultraviolet difference spectroscopy and circular dichroism studies

1978 • 140 citations

Pyridoxal 5'-phosphate as a site-specific protein reagent for a catalytically critical lysine residue in rabbit muscle phosphoglucose isomerase

1971 • 92 citations

Aspartate Transcarbamylase from Escherichia coli

1973 • 91 citations

Studies on the Antithrombin and Heparin Co-factor Activities of a Fraction Adsorbed from Plasma by Aluminum Hydroxide

1955 • 85 citations

Pyridoxamine-Pyruvate Transaminase. II. Characteristics of the Enzyme^*

1963 • 85 citations

Interaction of thrombin and heparin. Proflavine dye binding studies

1974 • 85 citations

Polyethylene glycol 6,000 enhancement of the clotting of fibrinogen solutions in visual and mechanical assays

1974 • 81 citations

The inactivation of thrombin and plasmin by antithrombin III in the presence of Sepharose-heparin

1977 • 80 citations

The role of heparin in the thrombin-antithrombin III reaction

1976 • 78 citations

Action of heparin on thrombin-antithrombin reaction

1975 • 77 citations

Role of heparin in the inactivation of thrombin, factor Xa, and plasmin by antithrombin III

1977 • 50 citations

Decreased Heparin Sensitivity of Cyclohexanedione-Modified Thrombin

1978 • 31 citations

Specific modification of an effector binding site of phosphofructokinase by pyridoxal phosphate

1976 • 22 citations

Ox liver glutamate dehydrogenase. The role of lysine-126 reappraised in the light of studies of inhibition and inactivation by pyridoxal 5'-phosphate

1975 • 21 citations

Modification of pig M4 lactate dehydrogenase by pyridoxal 5'-phosphate. Demonstration of an essential lysine residue

1975 • 21 citations

Fractionation of heparin by affinity chromatography on covalently-bound human α-thrombin

1978 • 20 citations

Tyrosine and tryptophan residues and amino groups in thrombin related to enzymic activities

1970 • 16 citations

Topology of Binding Sites for Carbamyl Phosphate in Aspartate Transcarbamylase from Escherichia coli

1975 • 14 citations

Specific modification of isoleucyl transfer ribonucleic acid synthetase by pyridoxal 5'-phosphate

1977 • 13 citations

Amidinated thrombin: Preparation and peptidase activity

1978 • 6 citations