Lazaroids: potent inhibitors of iron-dependent lipid peroxidation for neurodegenerative disorders

Basal Lipid Peroxidation in Substantia Nigra Is Increased in Parkinson's Disease

1989 • 1,369 citations

Transition Metals, Ferritin, Glutathione, and Ascorbic Acid in Parkinsonian Brains

1989 • 1,367 citations

The oxidant stress hypothesis in Parkinson's disease: Evidence supporting it

1992 • 925 citations

Pharmacology of Cerebral Ischemia

1989 • 675 citations

Central nervous systems trauma and strokeI. Biochemical considerations for oxygen radical formation and lipid peroxidation

1989 • 626 citations

β-Amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage

1990 • 620 citations

Novel 21-amino steroids as potent inhibitors of iron-dependent lipid peroxidation.

1987 • 474 citations

The neuroprotective pharmacology of methylprednisolone

1992 • 474 citations

Autopsy Samples of Alzheimer's Cortex Show Increased Peroxidation In Vitro

1990 • 456 citations

Effects of the 21-aminosteroid U74006F on experimental head injury in mice

1988 • 296 citations

21-Aminosteroid lipid peroxidation inhibitor U74006F protects against cerebral ischemia in gerbils.

1988 • 266 citations

Brain Hydroxyl Radical Generation in Acute Experimental Head Injury

1993 • 226 citations

Biochemistry and pharmacology of lipid antioxidants in acute brain and spinal cord injury.

1992 • 195 citations

The 21-aminosteroid inhibitors of lipid peroxidation: Reactions with lipid peroxyl and phenoxy radicals

1989 • 187 citations

Growth factors and vitamin E modify neuronal glutamate toxicity.

1992 • 167 citations

Tirilazad reduces cortical infarction after transient but not permanent focal cerebral ischemia in rats.

1992 • 146 citations

U-78517F: a potent inhibitor of lipid peroxidation with activity in experimental brain injury and ischemia.

1991 • 145 citations

A new 21-aminosteroid antioxidant lacking glucocorticoid activity stimulates adrenocorticotropin secretion and blocks arachidonic acid release from mouse pituitary tumor (AtT-20) cells.

1988 • 138 citations

21-Aminosteroid reduces ion shifts and edema in the rat middle cerebral artery occlusion model of regional ischemia.

1988 • 135 citations

Effects of tirilazad mesylate on postischemic brain lipid peroxidation and recovery of extracellular calcium in gerbils.

1991 • 111 citations

Mechanisms of blood-brain barrier breakdown

1991 • 104 citations

The Novel 21-Aminosteroid U74006F Attenuates Cerebral Edema and Improves Survival after Brain Injury in the Rat

1992 • 98 citations

A nonglucocorticoid steroid analog of methylprednisolone duplicates its high-dose pharmacology in models of central nervous system trauma and neuronal membrane damage.

1987 • 98 citations

Evidence for 21-aminosteroid association with the hydrophobic domains of brain microvessel endothelial cells

1991 • 97 citations

Pharmacology of cerebral ischemia

1992 • 78 citations

Tirilazad Mesylate Protects Vitamins C and E in Brain Ischemia‐Reperfusion Injury

1992 • 67 citations

The effects of two 21-aminosteroids on overt infarct size 48 hours after middle cerebral artery occlusion in the rat

1991 • 54 citations

Interaction of antioxidants with depth-dependent fluorescence quenchers and energy transfer probes in lipid bilayers

1992 • 43 citations

Effects of a 21-aminosteroid (U-74006F) on cerebral metabolites and edema after severe experimental head trauma.

1990 • 40 citations

Intensive anti-oxidant pretreatment retards motor nerve degeneration

1987 • 34 citations

Calcium and phosphorus in dementia

1990 • 34 citations

Impact of oxidized lipids and antioxidants, such as vitamin E and lazaroids, on the structure and dynamics of unsaturated membranes

1992 • 28 citations

Diquat-induced oxidative damage in hepatic microsomes: Effects of antioxidants

1991 • 25 citations

Methylprednisolone preservation of motor nerve function during early degeneration

1984 • 20 citations

Preservation of motor nerve function during early degeneration by the 21-aminosteroid anti-oxidant U74006F

1990 • 18 citations

Protective effects of a 21-aminosteroid against copper-induced erythrocyte and plasma lipid peroxidation

1992 • 18 citations

U-74, 006F, A 21-Aminosteroid, Does not Ameliorate Feline Focal Cerebral Ischemia

1990 • 8 citations

STUDIES ON THE PHARMACOLOGY OF METAPHEN AND ACRIFLAVINE

1932 • 4 citations