Mechanisms of blood-brain barrier breakdown

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.

1989 • 1,744 citations

The Concept of a Blood-Brain Barrier

1980 • 812 citations

An Easier, Reproducible, and Mass‐Production Method to Study the Blood–Brain Barrier In Vitro

1990 • 534 citations

The biphasic opening of the blood-brain barrier to proteins following temporary middle cerebral artery occlusion

1985 • 354 citations

Astrocyte-mediated induction of tight junctions in brain capillary endothelium: an efficient in vitro model

1987 • 353 citations

Pathophysiological Aspects of Brain Edema

1972 • 322 citations

Mediators of Blood-Brain Barrier Dysfunction and Formation of Vasogenic Brain Edema

1988 • 294 citations

DURATION AND SELECTIVITY OF BLOOD-BRAIN BARRIER BREAKDOWN IN CHRONIC RELAPSING EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS STUDIED BY GADOLINIUM-DTPA AND PROTEIN MARKERS

1990 • 215 citations

The blood-brain barrier to horseradish peroxidase under normal and experimental conditions

1977 • 177 citations

Ultrastructural characteristics of the brain and blood-brain barrier in experimental seizures

1977 • 165 citations

Glial Cells Influence Polarity of the Blood-Brain Barrier

1984 • 164 citations

Leukotrienes increase blood‐brain barrier permeability following intraparenchymal injections in rats

1985 • 155 citations

Permeability of the Blood‐Brain Barrier to the Immunosuppressive Cyclic Peptide Cyclosporin A

1990 • 128 citations

Brain lactic acidosis and ischemic cell damage: Quantitative ultrastructural changes in capillaries of rat cerebral cortex

1983 • 125 citations

Cortical blindness due to osmotic disruption of the blood‐brain barrier by angiographic contrast material

1989 • 125 citations

Effects of histamine on brain capillaries

1982 • 113 citations

A new aspect of the protective functions of the blood-brain barrier: Activities of four drug-metabolizing enzymes in isolated rat brain microvessels

1988 • 109 citations

Permeability and vasomotor response of cerebral vessels during exposure to arachidonic acid

1987 • 107 citations

Positron emission tomographic measurement of blood‐to‐brain and blood‐to‐tumor transport of ⁸²Rb: The effect of dexamethasone and whole‐brain radiation therapy

1985 • 107 citations

The blood-brain barrier in health and disease

1987 • 87 citations

Blood-brain barrier breakdown by cold injury. Polyamine signals mediate acute stimulation of endocytosis, vesicular transport, and microvillus formation in rat cerebral capillaries.

1986 • 85 citations

Radiographic contrast agents

1978 • 82 citations

Effects of methylprednisolone on peritumoral brain edema

1983 • 79 citations

Blood–Brain Barrier Breakdown in Cold‐Injured Brain Is Linked to a Biphasic Stimulation of Ornithine Decarboxylase Activity and Polyamine Synthesis: Both Are Coordinately Inhibited by Verapamil, Dexamethasone, and Aspirin

1989 • 78 citations

Changes in the effectiveness of the blood-brain and blood-spinal cord barriers in experimental allergic encephalomyelitis

1981 • 75 citations

Comparative Physiology of the Blood-Brain Barrier

1992 • 75 citations

Capillary permeability factor secreted by malignant brain tumor

1990 • 70 citations

A calcium‐dependent reversible permeability increase in microvessels in frog brain, induced by serotonin.

1985 • 68 citations

Differentiation of Brain Endothelial Cells in Cell Culture

1991 • 67 citations

The effect of dexamethasone on serum protein extravasation and edema development in experimental brain tumors of cat

1983 • 58 citations

Free oxygen radicals decrease electrical resistance of microvascular endothelium in brain

1987 • 57 citations

Neovasculature and blood-brain barrier in ischemic brain infarct

1988 • 55 citations

Middle Cerebral Artery Thrombosis: Acute Blood-Brain Barrier Consequences

1988 • 47 citations

Blood-Brain Barrier Disruption in the Treatment of Brain Tumors

1989 • 43 citations

Blood-Brain Barrier Disruption in the Treatment of Brain Tumors

1989 • 42 citations

Photochemically stimulated blood-borne factors induce blood-brain barrier alterations in rats.

1988 • 40 citations

Brain Tumors and the Blood-Tumor Barrier

1989 • 40 citations

Blood-brain barrier impairment by low pH buffer perfusion via the internal carotid artery in rat

1985 • 39 citations

Disturbances of the Blood-Brain Barrier in Cerebrovascular Disorders

1983 • 37 citations

Regulation of ion permeability in frog brain venules. Significance of calcium, cyclic nucleotides and protein kinase C.

1987 • 36 citations

Sequelae of the osmotic blood-brain barrier opening in rats

1988 • 36 citations

Polyamines mediate the reversible opening of the blood-brain barrier by the intracarotid infusion of hyperosmolal mannitol

1989 • 35 citations

Effects of Contrast Agents on the Blood-Brain Barrier An Electron Microscopic Study

1975 • 35 citations

Brain Microvessels Produce 12‐Hydroxyeicosatetraenoic Acid

1989 • 35 citations

A UNIFYING CONCEPT ON THE PATHOGENESIS OF BRAIN OEDEMAS

1987 • 35 citations

Polyamines and Ca²⁺ Mediate Hyperosmolal Opening of the Blood‐Brain Barrier: In Vitro Studies in Isolated Rat Cerebral Capillaries

1989 • 35 citations

Pathophysiological aspects of acute experimental allergic encephalomyelitis

1988 • 26 citations

Blood-brain barrier permeability and vascular reactivity to bradykinin after pretreatment with dexamethasone

1989 • 26 citations

Complement-derived polypeptide C3adesArg as a mediator of inflammation at the blood-brain barrier in a new experimental cat model

1989 • 23 citations

Cerebromicrovascular endothelial permeability

1987 • 23 citations

Cerebral Edema and the Blood-Brain Barrier

1989 • 17 citations

Steroids in Diseases of the Central Nervous System

1990 • 16 citations

The effect of dexamethasone on vascular permeability of experimental brain tumours

1986 • 15 citations

The Blood-Brain Barrier and the Immune System

1989 • 13 citations

The Effect of a Low pH Saline Perfusate upon the Integrity of the Energy-Depleted Rat Blood-Brain Barrier

1989 • 11 citations

CNS Imaging and the Brain Barriers

1989 • 10 citations

Local blood flow and vascular permeability of autonomic ganglion-transplants in the brain

1987 • 9 citations

Deleted Work

1955 • 0 citations