Altered phosphatidylcholine metabolism in C3H10T1/2 cells transfected with the Harvey-ras oncogene.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 47,127 citations

A simplification of the protein assay method of Lowry et al. which is more generally applicable

1977 • 8,485 citations

ras GENES

1987 • 3,818 citations

Two dimensional thin layer chromatographic separation of polar lipids and determination of phospholipids by phosphorus analysis of spots

1970 • 3,260 citations

A pharmacokinetic analysis program (multi) for microcomputer.

1981 • 2,465 citations

Quantitative measurement of sn-1,2-diacylglycerols present in platelets, hepatocytes, and ras- and sis-transformed normal rat kidney cells.

1986 • 999 citations

Induction of Membrane Ruffling and Fluid-Phase Pinocytosis in Quiescent Fibroblasts by ras Proteins

1986 • 725 citations

Activation of the T24 bladder carcinoma transforming gene is linked to a single amino acid change

1982 • 706 citations

Phosphatidate accumulation in hormone-treated hepatocytes via a phospholipase D mechanism.

1987 • 472 citations

Ras -Transformed Cells: Altered Levels of Phosphatidylinositol-4,5-Bisphosphate and Catabolites

1986 • 450 citations

Rapid formation of diacylglycerol from phosphatidylcholine: a pathway for generation of a second messenger.

1986 • 415 citations

Normal p21N-ras couples bombesin and other growth factor receptors to inositol phosphate production

1986 • 406 citations

Dissociation of bradykinin-induced prostaglandin formation from phosphatidylinositol turnover in Swiss 3T3 fibroblasts: evidence for G protein regulation of phospholipase A2.

1987 • 375 citations

The design and analysis of isotope experiments

1960 • 325 citations

Phospholipase D catalyzes phospholipid metabolism in chemotactic peptide-stimulated HL-60 granulocytes.

1988 • 307 citations

Stimulation of 1,2-diacylglycerol accumulation in hepatocytes by vasopressin, epinephrine, and angiotensin II.

1985 • 304 citations

Novel source of 1,2-diacylglycerol elevated in cells transformed by Ha-ras oncogene

1987 • 303 citations

A novel mechanism of diglyceride formation. 12-O-tetradecanoylphorbol-13-acetate stimulates the cyclic breakdown and resynthesis of phosphatidylcholine.

1986 • 267 citations

A SIMPLIFIED PURIFICATION OF LECITHIN

1951 • 258 citations

Phosphatidylcholine breakdown in rat liver plasma membranes. Roles of guanine nucleotides and P2-purinergic agonists.

1987 • 253 citations

Choline-linked Phosphoglycerides

1989 • 234 citations

Formation of lysophosphatidylcholine by human platelets in response to thrombin. Support for the phospholipase A2 pathway for the liberation of arachidonic acid.

1981 • 217 citations

Phorbol ester and neomycin dissociate bradykinin receptor-mediated arachidonic acid release and polyphosphoinositide hydrolysis in Madin-Darby canine kidney cells. Evidence that bradykinin mediates noninterdependent activation of phospholipases A2 and C.

1988 • 167 citations

Regulation of phospholipid metabolism in differentiating cells from rat brain cerebral hemispheres in culture. Patterns of acetylcholine phosphocholine, and choline phosphoglycerides labeling from (methyl-14C)choline.

1976 • 164 citations

Separation, purification, and characterization of ethanolamine kinase and choline kinase from rat liver

1974 • 159 citations

The phosphatidylcholine pathway of diacylglycerol formation stimulated by phorbol diesters occurs via phospholipase D activation

1988 • 156 citations

The purification and characterization of CTP:phosphorylcholine cytidylyltransferase from rat liver.

1986 • 143 citations

Regulation of phosphatidylcholine biosynthesis in mammalian cells. II. Effects of phospholipase C treatment on the activity and subcellular distribution of CTP:phosphocholine cytidylyltransferase in Chinese hamster ovary and LM cell lines.

1983 • 141 citations

Activation of alpha 1-adrenoceptors, protein kinase C, or treatment with intracellular free Ca2+ elevating agents increases pineal phospholipase A2 activity. Evidence that protein kinase C may participate in Ca2+-dependent alpha 1-adrenergic stimulation of pineal phospholipase A2 activity.

1987 • 140 citations

Bombesin and phorbol ester stimulate phosphatidylcholine hydrolysis by phospholipase C: Evidence for a role of protein kinase C

1987 • 127 citations

1,2-Diacylglycerols and phorbol esters stimulate phosphatidylcholine metabolism in GH3 pituitary cells. Evidence for separate mechanisms of action.

1987 • 124 citations

Vasopressin induces V1 receptors to activate phosphatidylinositol- and phosphatidylcholine-specific phospholipase C and stimulates the release of arachidonic acid by at least two pathways in the smooth muscle cell line, A-10.

1988 • 117 citations

Alpha 1-adrenergic receptors promote phosphatidylcholine hydrolysis in MDCK-D1 cells. A mechanism for rapid activation of protein kinase C.

1988 • 115 citations

Phospholipid synthesis in isolated fat cells. Studies of microsomal diacylglycerol cholinephosphotransferase and diacylglycerol ethanolaminephosphotransferase activities.

1977 • 108 citations

Elevated phosphocholine concentration in ras-transformed NIH 3T3 cells arises from increased choline kinase activity, not from phosphatidylcholine breakdown.

1989 • 106 citations

Tumor promoter stimulation of phosphatidylcholine turnover in HeLa cells.

1982 • 98 citations

Regulation of phosphatidylcholine biosynthesis in mammalian cells. III. Effects of alterations in the phospholipid compositions of Chinese hamster ovary and LM cells on the activity and distribution of CTP:phosphocholine cytidylyltransferase.

1983 • 95 citations

Stimulation of choline release from NG108-15 cells by 12-O-tetradecanoylphorbol 13-acetate

1987 • 86 citations

Partial down-regulation of protein kinase C in C3H 10T 1/2 mouse fibroblasts transfected with the human Ha-ras oncogene.

1988 • 63 citations

Cholinephosphotransferase in rat lung. The in vitro synthesis of dipalmitoylphosphatidylcholine from dipalmitoylglycerol.

1981 • 53 citations

Oncogene-mediated multistep transformation of C3H10T1/2 cells.

1987 • 37 citations

Trifluoperazine Stimulates the Coordinate Degradation of Sphingomyelin and Phosphatidylcholine in GH3 Pituitary Cells

1989 • 15 citations