Lens epithelial cells derived from αB‐crystallin knockout mice demonstrate hyperproliferation and genomic instability

A RAPID BANDING TECHNIQUE FOR HUMAN CHROMOSOMES

1971 • 5,049 citations

Genetic instabilities in human cancers

1998 • 4,165 citations

Cell Cycle Control and Cancer

1994 • 2,575 citations

Alpha-crystallin can function as a molecular chaperone.

1992 • 1,822 citations

A missense mutation in the αB-crystallin chaperone gene causes a desmin-related myopathy

1998 • 1,061 citations

A p53-Dependent Mouse Spindle Checkpoint

1995 • 668 citations

p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens

1994 • 617 citations

αB subunit of lens-specific protein α-crystallin is present in other ocular and non-ocular tissues

1989 • 538 citations

Evolution of the alpha-crystallin/small heat-shock protein family.

1993 • 464 citations

The small heat-shock protein αB-crystallin as candidate autoantigen in multiple sclerosis

1995 • 393 citations

Expression of the murine alpha B-crystallin gene is not restricted to the lens.

1989 • 377 citations

Differential disruption of genomic integrity and cell cycle regulation in normal human fibroblasts by the HPV oncoproteins.

1994 • 371 citations

Targeted disruption of the mouse αA-crystallin gene induces cataract and cytoplasmic inclusion bodies containing the small heat shock protein αB-crystallin

1997 • 332 citations

An oncogenic form of p53 confers a dominant, gain-of-function phenotype that disrupts spindle checkpoint control

1998 • 241 citations

Propagation and immortalization of human lens epithelial cells in culture.

1994 • 196 citations

cAMP-dependent phosphorylation of bovine lens alpha-crystallin.

1985 • 171 citations

Dementia, gliosis and expression of the small heat shock proteins hsp27 and αB-crystallin in Parkinsonʼs disease

1999 • 153 citations

Expression of the α-Crystallin/Small Heat-Shock Protein/Molecular Chaperone Genes in the Lens and other Tissues

1994 • 152 citations

Differential expression of alpha A- and alpha B-crystallin during murine ocular development.

1996 • 139 citations

C-myc overexpression and p53 loss cooperate to promote genomic instability

1999 • 137 citations

Tumorigenicity by human papillomavirus type 16 E6 and E7 in transgenic mice correlates with alterations in epithelial cell growth and differentiation

1993 • 126 citations

The Molecular Chaperone αA-Crystallin Enhances Lens Epithelial Cell Growth and Resistance to UVA Stress

1998 • 119 citations

αB Crystallin Accumulation Is a Specific Response to Ha-ras and v-mos Oncogene Expression in Mouse NIH 3T3 Fibroblasts

1991 • 95 citations

Intercellular communication between epithelial and fiber cells of the eye lens

1994 • 92 citations

Identification and Characterization of the Gene Encoding a New Member of the α-Crystallin/Small hsp Family, Closely Linked to the αB-Crystallin Gene in a Head-to-Head Manner

1997 • 92 citations

Synthesis of α-crystallin by a cell line derived from the lens of a transgenic animal

1990 • 76 citations

Conversion from Oligomers to Tetramers Enhances Autophosphorylation by Lens αA-Crystallin

1995 • 74 citations

Expression of growth control and differentiation genes in human lens epithelial cells with extended life span.

1998 • 72 citations

Preferential expression of αB-crystallin in astrocytic elements of neuroectodermal tumors

1991 • 70 citations

[13] Cell culture characterization: Monitoring for cell identification

1979 • 69 citations

Separation of Fibres from the Capsule Enhances Mitotic Activity of Human Lens Epithelium

1997 • 64 citations

The Myotonic Dystrophies

1999 • 62 citations

Genomic instability: first step to carcinogenesis.

2000 • 58 citations

Immortalization of epithelial cells

1996 • 54 citations

Neoplastic transformation of human cells in vitro.

1993 • 51 citations

Alpha B crystallin accumulation is a specific response to Ha-ras and v-mos oncogene expression in mouse NIH 3T3 fibroblasts.

1991 • 50 citations

Genomic Instability and Its Role in Neoplasia

1997 • 50 citations

Tissue culture of lens epithelial cells from normal and Nakano mice.

1977 • 49 citations

αB-Crystallin Interacts with Cytoplasmic Intermediate Filament Bundles during Mitosis

1999 • 48 citations

Ectopic expression of αB-crystallin in Chinese hamster ovary cells suggests a nuclear role for this protein

1999 • 46 citations

Cell cycle regulation in the lens: Proliferation, quiescence, apoptosis and differentiation

1997 • 42 citations

Control of Cell Division in the Ocular Lens, Retina, and Vitreous Humor

1982 • 39 citations

Perturbed development of the mouse lens by polyomavirus large T antigen does not lead to tumor formation.

1989 • 39 citations

Immunohistochemical demonstration of alphaB-crystallin in hamartomas of tuberous sclerosis.

1991 • 38 citations

The dephosphorylation of lens α-crystallin a chain

1989 • 37 citations

Recruitment of enzymes and stress proteins as lens crystallins

1994 • 31 citations

Expression of stress genes during development

1995 • 24 citations

The v-mos and c-Ha-ras oncoproteins exert similar effects on the pattern of protein synthesis.

1989 • 18 citations

Chromosomal imbalances and DNA amplifications in SV40 large T antigen-induced primitive neuroectodermal tumor cell lines of the rat

1999 • 13 citations

Establishment of lens epithelial cell lines from Emory and cataract resistant mice and their response to hydrogen peroxide.

1989 • 12 citations

Transformation by T-antigen and other oncogenes delays Hsp25 accumulation in heat shocked NIH 3T3 fibroblasts

1997 • 6 citations

Genomic instability associated with myotonic dystrophy does not involve p53 expression and activity

1998 • 3 citations