Neoplastic progression in ulcerative colitis: Histology, DNA content, and loss of a p53 allele

Genetic Alterations during Colorectal-Tumor Development

1988 • 6,691 citations

The p53 tumour suppressor gene

1991 • 3,871 citations

Basic Methods in Molecular Biology

1986 • 3,284 citations

Mutations in the p53 gene occur in diverse human tumour types

1989 • 2,765 citations

Chromosome 17 Deletions and p53 Gene Mutations in Colorectal Carcinomas

1989 • 2,081 citations

Dysplasia in inflammatory bowel disease: Standardized classification with provisional clinical applications

1983 • 1,856 citations

Mutational hot spot in the p53 gene in human hepatocellular carcinomas

1991 • 1,525 citations

Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa

1991 • 1,418 citations

p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis.

1990 • 1,080 citations

Purification of DNA from formaldehyde fixed and paraffin embedded human tissue

1985 • 821 citations

DNA aneuploidy in colonic biopsies predicts future development of dysplasia in ulcerative colitis

1992 • 554 citations

Colorectal cancer in ulcerative colitis: a cohort study of primary referrals from three centres.

1988 • 506 citations

Frequent mutation of the p53 gene in human esophageal cancer.

1990 • 393 citations

The influence of tumour cell DNA abnormalities on survival in colorectal cancer

1985 • 281 citations

p53 gene mutations in Barrett's epithelium and esophageal cancer.

1991 • 266 citations

Detection of frequent p53 gene mutations in primary gastric cancer by cell sorting and polymerase chain reaction single-strand conformation polymorphism analysis.

1991 • 230 citations

Codon 72 polymorphism of the TP53 gene

1990 • 225 citations

Reduction to homozygosity involving p53 in esophageal cancers demonstrated by the polymerase chain reaction.

1991 • 162 citations

C-Ki-ras mutations in chronic ulcerative colitis and sporadic colon carcinoma

1990 • 150 citations

Occurrence of p53 Gene Abnormalities in Gastric Carcinoma Tumors and Cells Lines

1991 • 131 citations

Dysplasia and Deoxyribonucleic Acid Aneuploidy in the Assessment of Precancerous Changes in Chronic Ulcerative Colitis

1988 • 122 citations

Carcinoma of the colon in ulcerative colitis

1964 • 122 citations

Activation of c-Ki-ras in human gastrointestinal dysplasias determined by direct sequencing of polymerase chain reaction products.

1990 • 100 citations

Distribution of aneuploid cell populations in ulcerative colitis with dysplasia or cancer

1991 • 97 citations

Accll polymorphism of the p53 gene

1990 • 86 citations

Molecular analysis of the p53 alleles in primary hepatocellular carcinomas and cell lines.

1991 • 74 citations

Carcinoma and Ulcerative Colitis a Clinical-Pathologic Study

1958 • 69 citations

Frequent Loss of a p53 Allele in Carcinomas and their Precursors in Ulcerative Colitis

1991 • 62 citations

Carcinoma and ulcerative colitis, a clinical-pathologic study. II. Statistical analysis.

1958 • 58 citations

The p53 tumor suppressor gene and gene product.

1989 • 57 citations

Analysis of c-Ki-ras mutations in human colon carcinoma by cell sorting, polymerase chain reaction, and DNA sequencing.

1989 • 51 citations

Ulcerative Colitis and Colon Cancer

1988 • 50 citations

Deoxyribonucleic acid ploidy and cell cycle events in benign colonic epithelium peripheral to carcinoma.

1988 • 17 citations

New Technologies in Cytometry

1989 • 7 citations

Flow Cytometric Changes That Precede Cancer: Premalignant Gastrointestinal Disease

1989 • 6 citations