Circadian variation of 5-fluorouracil catabolism in isolated perfused rat liver.

Clinical Pharmacology of 5-Fluorouracil

1989 • 910 citations

Familial deficiency of dihydropyrimidine dehydrogenase. Biochemical basis for familial pyrimidinemia and severe 5-fluorouracil-induced toxicity.

1988 • 500 citations

Interaction of Mixed‐Function Oxidation with Biosynthetic Processes

1973 • 305 citations

Enzymes of uracil catabolism in normal and neoplastic human tissues.

1985 • 282 citations

Daily rhythmic variation in hepatic drug metabolism in the rat and mouse.

1968 • 224 citations

Circadian rhythm-varying plasma concentration of 5-fluorouracil during a five-day continuous venous infusion at a constant rate in cancer patients.

1988 • 163 citations

Rapid catabolism of 5-fluorouracil in freshly isolated rat hepatocytes as analyzed by high performance liquid chromatography.

1982 • 145 citations

Degradation of pyrimidines and pyrimidine analogs—Pathways and mutual influences

1980 • 117 citations

Clinical pharmacological studies of concurrent infusion of 5-fluorouracil and thymidine in treatment of colorectal carcinomas.

1982 • 110 citations

Combination clinical trials with thymidine and fluorouracil: A phase I and clinical pharmacologic evaluation

1980 • 85 citations

Circadian rhythm of rat liver dihydropyrimidine dehydrogenase

1988 • 75 citations

Investigative Methodology for Chronobiology

1983 • 40 citations

Circadian pattern of continuous FUDR infusion reduces toxicities.

1987 • 36 citations

Circadian-based infusional chrono-chemotherapy controls progressive metastatic renal cell carcinoma.

1988 • 25 citations

Dihydropyrimidine Dehydrogenase Activity in Human Blood Mononuclear Cells

1989 • 24 citations