Degradation of pyrimidines and pyrimidine analogs—Pathways and mutual influences

Thymidylate synthetase - a target enzyme in cancer chemotherapy

1977 • 514 citations

The specific mutagenic effect of base analogues on Phage T4

1959 • 389 citations

Fluorinated Pyrimidines and Their Nucleosides

1975 • 333 citations

The Molecular Biology of Cancer

1974 • 298 citations

Degradation of purines and pyrimidines by microorganisms.

1976 • 270 citations

Fluorinated Pyrimidines

1965 • 252 citations

Studies on fluorinated pyrimidines. III. The metabolism of 5-fluorouracil-2-C14 and 5-fluoroorotic-2-C14 acid in vivo.

1958 • 247 citations

Mode of Action of 5-Fluorocytosine and Mechanisms of Resistance

1975 • 244 citations

Antineoplastic and Immunosuppressive Agents

1975 • 236 citations

Cell kinetics and chemotherapy: a critical review.

1978 • 224 citations

Genetic and Physiological Aspects of Resistance to 5-Fluoropyrimidines in Saccharomyces cerevisiae

1970 • 198 citations

Flucytosine

1977 • 183 citations

Nucleotide pools of Novikoff rat hepatoma cells growing in suspension culture. I. Kinetics of incorporation of nucleosides into nucleotide pools and pool sizes during growth cycle

1971 • 181 citations

PYRIMIDINE METABOLISM

1956 • 178 citations

Inhibition of Ribosomal Ribonucleic Acid Maturation in Novikoff Hepatoma Cells by 5-Fluorouracil and 5-Fluorouridine

1973 • 157 citations

The Utilization of Exogenous Pyrimidines and the Recycling of Uridine‐5′‐Phosphate Derivatives in Saccharomyces cerevisiae, as Studied by Means of Mutants Affected in Pyrimidine Uptake and Metabolism

1969 • 151 citations

A phase III study comparing the clinical utility of four regimens of 5-Fluorouracil.A preliminary report

1977 • 150 citations

Mode of action of 5-fluorocytosine

1978 • 137 citations

Studies on fluorinated pyrimidines

1959 • 135 citations

The cellular location of dihydroorotate dehydrogenase: Relation to de novo biosynthesis of pyrimidines

1976 • 135 citations

Metabolic fate of pyrimidines and purines in dietary nucleic acids ingested by mice

1978 • 134 citations

The metabolism of 5-fluorocytosine-214C and of cytosine-14C in the rat and the disposition of 5-fluorocytosine-214C in man

1966 • 133 citations

Studies of Fluorinated Pyrimidines. XVIII. The Degradation of 5-Fluoro-2'-deoxyuridine and Related Compounds by Nucleoside Phosphorylase^*

1963 • 131 citations

Evidence for Conversion of 5-Fluorocytosine to 5-Fluorouracil in Humans: Possible Factor in 5-Fluorocytosine Clinical Toxicity

1978 • 129 citations

Studies on Fluorinated Pyrimidines

1960 • 126 citations

Studies on Fluorinated Pyrimidines XVI. Metabolism of 5-Fluorouracil-2-C14 and 5-Fluoro-2′-deoxyuridine-2-C14 in Cancer Patients

1963 • 126 citations

Biochemical determinants of 5-fluorouracil response in vivo. The role of deoxyuridylate pool expansion.

1975 • 121 citations

ACTIONS OF DRUGS ON SINGLE NEURONES IN THE CEREBRAL CORTEX

1965 • 118 citations

Pharmacokinetics of fluorouracil in humans.

1978 • 118 citations

Evidence for a Common Transport System for Cytosine, Adenine and Hypoxanthine in Saccharomyces cerevisiae and Candida albicans

1973 • 106 citations

Pharmacokinetic Studies on the Oral Antimycotic Agent 5-Fluorocytosine in Individuals with Normal and Impaired Kidney Function

1973 • 102 citations

Studies on resistance against 5-fluorouracil. I. Enzymes of the uracil pathway during development of resistance.

1962 • 99 citations

Chemical carcinogenesis, chemotherapy: cancer's continuing core challenges--G. H. A. Clowes Memorial Lecture.

1970 • 93 citations

Pyrimidine Metabolism

1959 • 93 citations

Control of gene expression in carbohydrate, pyrimidine and DNA metabolism

1971 • 93 citations

Ionization of DNA bases or base analogues as a possible explanation of mutagenesis, with special reference to 5-bromodeoxyuridine

1962 • 89 citations

Pharmacokinetics of the fluoropyrimidines: implications for their clinical use

1976 • 89 citations

A SURVEY OF EFFECTS OF CHEMICALS ON DIVISION AND GROWTH OF YEAST AND ESCHERICHIA COLI

1954 • 88 citations

Clinical evaluation of ftorafur (pyrimidine-deoxyribose n1-2'-furanidyl-5-fluorouracil).

1976 • 87 citations

THE CATABOLISM OF C14-LABELED URACIL, DIHYDROURACIL, AND β-UREIDOPROPIONIC ACID IN RAT LIVER SLICES

1957 • 82 citations

Orotic acid biosynthesis in rat liver: Studies on the source of carbamoylphosphate

1977 • 82 citations

Characterization of cytosine permeation in Saccharomyces cerevisiae

1975 • 74 citations

Dihydrouracil dehydrogenase activity in normal, differentiating and regnerating liver and in hepatomas.

1971 • 74 citations

Behavior of opposing pathways of thymidine utilization in differentiating, regenerating, and neoplastic liver.

1971 • 70 citations

Proceedings of the Symposium

1976 • 69 citations

Biochemical strategy of the genome as expressed in regulation of pyrimidine metabolism

1978 • 68 citations

The Role of the Membrane in the Utilization of Nucleic Acid Precursor

1974 • 66 citations

Disposition and metabolism of 1-(tetrahydro-2-furanyl)-5-fluorouracil (ftorafur) in humans.

1978 • 66 citations

Thymidylate synthetase. Catalysis of dehalogenation of 5-bromo- and 5-iodo-2'-deoxyuridylate

1979 • 65 citations

Mechanism of Action and Application of Azapyrimidines

1963 • 65 citations

Mediated transport of nucleosides by human erythrocytes specificity toward purine nucleosides as permeants

1973 • 63 citations

Antimetabolites of Nucleic Acid Metabolism

1951 • 61 citations

Specific inhibition of transfer RNA methylation and modification in tissues of mice treated with 5-fluorouracil.

1978 • 60 citations

Metabolic Studies with 5-Fluorocytosine-6-<sup>14</sup>C in Mouse, Rat, Rabbit, Dog and Man

1976 • 59 citations

Regulation of nucleotidase activities in animal tissues

1978 • 53 citations

The relationship of thymidine metabolism to the use of fractional incorporation as a measure of DNA synthesis and tissue proliferation

1978 • 52 citations

New developments on the mechanisms of action of antineoplastic drugs

1979 • 49 citations

Tumor 5-fluorodeoxyuridylate concentration as a determinant of 5-fluorouracil response

1978 • 49 citations

Synergism of Polyene Antibiotics with 5-Fluorocytosine

1978 • 48 citations

The Kinetics of 5-Fluorocytosine Elimination in Man

1972 • 48 citations

Role of catabolism in pyrimidine utilization for nucleic acid synthesis in vivo.

1972 • 46 citations

Thymidylate synthetase catalyzed dehalogenation of 5-bromo-and 5-iodo-2′-deoxyuridylate

1975 • 46 citations

Uridine kinase activities and pyrimidine nucleoside phosphorylation in fluoropyrimidine-sensitive and -resistant cell lines of the Novikoff hepatoma

1977 • 45 citations

Degradation of Pyrimidines — Enzymes, Localization and Role in Metabolism

1978 • 44 citations

Studies on Fluorinated Pyrimidines XVII. Tissue Distribution of 5-Fluorouracil-2-C14 and 5-Fluoro-2′-deoxyuridine in Cancer Patients

1963 • 44 citations

Perspectives in the Treatment of Breast Cancer: 1976

1977 • 44 citations

The Relation between Uracil-catabolizing Enzymes and Rate of Rat Liver Regeneration

1962 • 43 citations

Studies of a Mutation Affecting Pyrimidine Degradation in Inbred Mice

1970 • 42 citations

On the mechanism of action of antibiotics which act as irreversible enzyme inhibitors

1975 • 42 citations

Antitumor activity of 1-hexylcarbamoyl-5-fluorouracil in a variety of experimental tumors.

1976 • 40 citations

Molecular Correlation Concept

1974 • 39 citations

Ordered and specific pattern of gene expression in neoplasia

1973 • 38 citations

Pyrimidine-degrading enzymes. Purification and properties of β-ureidopropionase of Euglena gracilis

1979 • 37 citations

Irreversible inhibition of dehalogenation of 5-iodouracil by 5-diazouracil and reversible inhibition by 5-cyanouracil.

1970 • 33 citations

Ambiguity of the thymidine index.

1976 • 32 citations

Fungistatic Activity, Uptake and Incorporation of 5-FIuorocytosine in <i>Candida albicans, </i>as influenced by Pyrimidines and Purines

1973 • 31 citations

Iododeoxyuridine administered to mice is de-iodinated and incorporated into DNA primarily as thymidylate

1979 • 31 citations

Dihydroorotic Acid Dehydrogenase Activity of Human Diploid Cell Strains

1968 • 30 citations

Increased formation of nucleotide derivatives of 5‐fluorouridine in hepatoma cells treated with inhibitors of pyrimidine synthesis and D‐galactosamine

1978 • 30 citations

The reduction of thymine by human leukocytes

1964 • 30 citations

Substrate specificity of the dihydro-uracil dehydrogenase and uridine phosphorylase of rat liver

1962 • 27 citations

Fluoroacetate toxicity inThiobacillus neapolitanus and its relevance to the problem of obligate chemoautotrophy

1968 • 26 citations

Dihydrouracil Dehydrogenase of Rat Liver

1971 • 26 citations

Solid tumour models for the assessment of different treatment modalities: IV. the combined effects of radiation and 5-fluorouracil

1976 • 25 citations

Enhancement of the antitumor activity of 5-fluorouracil by drug combinations.

1973 • 25 citations

The Influence of 5-FIuorocytosine on Nucleic Acid Synthesis in <i>Candida albicans, Cryptococcus neoformans</i>, and <i>Aspergillus fumigatus</i>

1977 • 25 citations

Effects of natural pyrimidines and of certain related compounds on the spontaneous activity of the mouse.

1978 • 25 citations

Some aspects of the metabolism of 5-bromouracil

1959 • 25 citations

Inhibition by barbituric acid and its derivatives of the enzymes in rat brain which participate in the synthesis of pyrimidine ribotides

1978 • 24 citations

Growth-physiological Changes in Escherichia coli and Other Bacteria During Division Inhibition by 5-Diazouracil

1969 • 24 citations

Partial purification and characterization of dihydropyrimidinases from calf and rat liver.

1978 • 24 citations

Beta-aminoisobutyric acid, a new probe for the metabolism of DNA and RNA in normal and tumorous tissue.

1974 • 24 citations

Antitumor activity of 1-alkylcarbamoyl derivatives of 5-fluorouracil against L1210 leukemia.

1978 • 22 citations

Incorporation of precursors and inhibitors of nucleic acid synthesis into hepatomas and liver of the rat.

1974 • 22 citations

Synthetic pyrimidines as inhibitors of uracil and thymine degradation by rat-liver supernatant

1964 • 22 citations

Kinetic alterations induced by 5-fluorouracil in bone marrow, intestinal mucosa, and tumor.

1976 • 21 citations

Identification of the metabolites of bromacil in rat urine

1969 • 21 citations

Effects of 5-fluorocytosine on protein synthesis and amino acid pool inCandida albicans

1974 • 20 citations

Buffer-catalyzed tautomerism of uracil monoanion

1971 • 19 citations

Comparison of 5-fluorouracil and ftorafur. I. Quantitative and qualitative differences in toxicity to mice.

1976 • 19 citations

Inhibition of uracil and thymine degradation by some 5-substituted uracil analogues

1961 • 19 citations

Inhibition of rat dihydropyrimidine dehydrogenase by 5-cyanouracil in vitro.

1969 • 19 citations

In vivo inhibition of pyrimidine catabolism by 5-cyanouracil.

1971 • 19 citations

Identification of the metabolites of terbacil in dog urine

1969 • 18 citations

Thymine and Uracil Catabolism in Escherichia coli

1972 • 18 citations

Quantitative analysis of 5-fluorouracil in human serum by selected ion monitoring gas chromatography—mass spectrometry

1978 • 18 citations

A biochemical and pharmacological study of therapeutic synergism with 5-fluorouracil plus cyclophosphamide in murine L1210 leukemia.

1979 • 17 citations

Stimulation of plant development by some uracil analogues

1960 • 17 citations

Understanding the actions of carcinostatic drugs to improve chemotherapy: 5-fluorouracil

1978 • 17 citations

Response of DNA thymine synthesis in human tumor and normal tissue to 5-fluorouracil.

1972 • 17 citations

Resistance of Mammalian Tumour Cells toward Pyrimidine Analogues

1973 • 17 citations

Metabolism and Disposition of Baker's Antifolate (NSC-139105), Ftorafur (NSC-148958), and Dichlorallyl Lawsone (NSC-126771) in Man

1978 • 16 citations

Role of enzymatically catalyzed 5-iodo-5,6-dihydrouracil ring hydrolysis on the dehalogenation of 5-iodouracil.

1976 • 16 citations

Comparison of 5-fluorouracil and ftorafur. II. Therapeutic response and development of resistance in murine tumors.

1976 • 16 citations

Degradation of pyrimidines in Euglena gracilis II. Inhibition of degradation by structural analogues and their own degradation

1977 • 15 citations

Dihydropyrimidinase. Metabolism of some cyclic imides of different ring size.

1978 • 15 citations

Properties of three distinct pyrimidine transport systems in yeast. Evidence for distinct energy coupling

1978 • 15 citations

The effect of thiols on the dehalogenation of 5-iodo and 5-bromouracil

1973 • 15 citations

Dihydropyrimidinase. Stereochemistry of the metabolism of some 5-alkylhydantoins.

1978 • 14 citations

Evidence for role of purine nucleoside phosphorylase in sensitivity of Novikoff hepatoma cells to 5-fluorouracil

1977 • 14 citations

Effect of 5-fluorouracil and thymidine on the transmembrane potential and zeta potential of HeLa cells.

1978 • 14 citations

Pyrimidine reducing enzymes of rat liver

1976 • 14 citations

Some pyrimidine derivatives as new types of plant stimulants

1960 • 14 citations

Fifty-five percent complete remission of mammary carcinoma in mice with 5-fluorouracil and chloroquine.

1978 • 14 citations

Antitumor activity of carbamoyl derivatives of 5-fluorouracil by oral administration.

1975 • 12 citations

Solvolysis of 5-Halouridines and Related Nucleosides

1968 • 12 citations

In vivo Metabolite-antimetabolite relationships in antitumor therapy

1978 • 12 citations

Effect of water on the tautomeric equilibrium of uracil monoanions. A PCILO study

1976 • 12 citations

Delayed synthesis of uracil-degrading enzymes in regenerating rat liver

1964 • 11 citations

The dehalogenation of iodouracil by cysteine. Intramolecular general-acid catalysis of cysteine addition to 5-iodouracil

1974 • 10 citations

The effect of uracil analogues on the metabolism of pyrimidines in cucumber seedlings

1960 • 10 citations

Biochemical and kinetic approaches to inhibition of multiple pathways

1979 • 10 citations

Effect of Uracil and 5‐Nitrouracil on Growth and Flowering of Tomato

1968 • 9 citations

5,6-Dihydrouracil: Its occurrence and metabolism in rat brain

1970 • 9 citations

Transformations of uracil analogues in cucumber seedlings

1960 • 9 citations

Relationship between urinary beta-aminoisobutyric acid and transfer RNA turnover in cancer patients.

1974 • 9 citations

The addition of bisulfite to 5-fluorouracil. Evidence for a change in rate determining step

1974 • 9 citations

The role of bisulfite in the debromination of 5-bromouracil

1974 • 8 citations

Transport of Antineoplastic Agents

1974 • 8 citations

Stimulatory Effect of Purine and Pyrimidine Bases and their Role in the Mediation of Auxin Action through the Regulation of Carbohydrate Metabolism during Adventitious Root Formation in Hypocotyl Cuttings of Phaseolus mungo

1978 • 8 citations

Interference between the Uptake of Pyrimidines and Purines in Yeasts

1973 • 8 citations

Effect of 5-Diazouracil on the Synthetic and Catabolic Utilization of Thymine in Rat Liver

1972 • 7 citations

Inhibition by 6-aminothymine of the degradation of nucleosides (5-iododeoxyuridine, thymidine) and pyrimidine bases (5-iodouracil, uracil and 5-fluorouracil) in vivo.

1974 • 7 citations

Notizen: A note on in vitro inhibition of thymine degradation by some pyrimidine analogues and related products

1969 • 7 citations

Metabolism of Thymine in Tumor Tissue: The Origins of β-aminoisobutyric Acid

1975 • 7 citations

Enhancement of antileukemic effect in combination of 5-fluorouracil and OK-432.

1977 • 7 citations

The dehalogenation of halocytosines by bisulfite buffers

1975 • 7 citations

Study of the mechanism of the growth-inhibiting effect of 3-oxauracil in Escherichia coli

1974 • 7 citations

The dehalogenation of the 5-halo-5,6-dihydrouracils

1976 • 6 citations

Catabolic degradation of 6-azauracil and 6-azauridine by Pseudomonas putida

1977 • 6 citations

Inhibition of metabolism of β-alanine and D-β-aminoisobutyric acid by D-cycloserine

1976 • 6 citations

A theory for the chemical mediation of the excitability of the brain, with special reference to natural and drug-induced sleep

1977 • 6 citations

The growth stimulating effect of 5-bromouracil and uracil on chlorococcal algae

1974 • 5 citations

Physical properties of pyrimidine and purine antimetabolites. II. Permeation of 5-fluorouracil and 1-(2-tetrahydrofuryl)-5-fluorouracil through cellophane, collagen, and silicone membranes.

1976 • 5 citations

Influence of some derivatives and structural analogues of pyrimidine and purine bases on the degradation of uracil

1963 • 5 citations

Effects of Purines and Pyrimidines on the Fungistatic Activity of 5-Fluorocytosine in Aspergillus Species

1977 • 5 citations

Incorporation of 5-Diazouracil- 2 - ¹⁴ C into Ribonucleic Acids of Escherichia coli During Division Inhibition

1970 • 4 citations

Abnormal excretion of .BETA.-aminoisobutyric acid in urine of the rats injected with 1-aminoproline and its stereospecificity.

1978 • 3 citations

Pharmacological considerations in combination chemotherapy

1977 • 3 citations

The stimulatory effect of uracil and 5-bromouracil on the seed set inPapaver somniferum L.

1972 • 3 citations

The intramolecular cyclization of 2-iodo-3-ureidopropionic acid

1978 • 2 citations

On the mode of action of 5-diazouracil on bacterial cell division

1976 • 1 citations