Circadian rhythm-varying plasma concentration of 5-fluorouracil during a five-day continuous venous infusion at a constant rate in cancer patients.

Methods for cosinor-rhythmometry.

1979 • 1,693 citations

A clinical-pharmacological evaluation of hepatic arterial infusions of 5-fluoro-2'-deoxyuridine and 5-fluorouracil.

1978 • 516 citations

Comparison of continuously infused 5-fluorouracil with bolus injection in treatment of patients with colorectal adenocarcinoma

1975 • 420 citations

Circadian Timing of Cancer Chemotherapy

1985 • 358 citations

Clinical trial of cisplatin and 5-FU infusion as initial treatment for advanced squamous cell carcinoma of the head and neck.

1982 • 234 citations

Daily rhythmic variation in hepatic drug metabolism in the rat and mouse.

1968 • 224 citations

Circadian Changes of Drug Disposition in Man

1982 • 220 citations

The pharmacology of the fluoropyrimidines.

1981 • 189 citations

Rapid catabolism of 5-fluorouracil in freshly isolated rat hepatocytes as analyzed by high performance liquid chromatography.

1982 • 145 citations

Continuous infusion chemotherapy: a critical review.

1984 • 138 citations

Clinical pharmacological studies of concurrent infusion of 5-fluorouracil and thymidine in treatment of colorectal carcinomas.

1982 • 110 citations

Clinical pharmacokinetic study of 5-FU in continuous 5-day infusions for head and neck cancer

1986 • 110 citations

Clinical response and plasma levels of 5-fluorouracil in patients with colonic cancer treated by drug infusion

1978 • 105 citations

Steady-state nonlinear pharmacokinetics of 5-fluorouracil during hepatic arterial and intravenous infusions in cancer patients.

1986 • 94 citations

Comparison of liquid- and gas-liquid chromatographic assays of 5-fluorouracil in plasma.

1979 • 84 citations

Induction chemotherapy with cis-platinum and 5-fluorouracil for squamous cell carcinoma of the head and neck

1986 • 75 citations

Comparison of pharmacokinetics of 5-fluorouracil and 5-fluorouracil with concurrent thymidine infusions in a Phase I trial.

1980 • 73 citations

Effect of Biological Time on the Determination of the LD<sub>50</sub> of 5-Fluorouracil in Mice

1984 • 52 citations

Plasma pharmacokinetics of 5-FU given by continuous infusion with allopurinol.

1986 • 36 citations

Continuous 5-day regional chemotherapy by 5-fluorouracil in colon carcinoma: Pharmacokinetic evaluation

1985 • 31 citations

Interindividual Differences in the Circadian Hematologic Time Structure of Cancer Patients

1986 • 22 citations

Blood levels of 5-fluorouracil during intravenous infusion

1976 • 16 citations