5-HT3 receptors and neurotransmitter release in the CNS: a nerve ending story?

Magnesium gates glutamate-activated channels in mouse central neurones

1984 • 3,999 citations

A review of central 5-HT receptors and their function

1999 • 3,121 citations

International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin).

1994 • 2,935 citations

Primary Structure And Functional Expression of the 5HT ₃ Receptor, A Serotonin-gated Ion Channel

1991 • 976 citations

5-HT3 receptors are membrane ion channels

1989 • 630 citations

PRESYNAPTIC IONOTROPIC RECEPTORS AND THE CONTROL OF TRANSMITTER RELEASE

1999 • 578 citations

The 5-HT3B subunit is a major determinant of serotonin-receptor function

1999 • 555 citations

Nervous system distribution of the serotonin 5-HT3 receptor mRNA.

1993 • 369 citations

The 5-HT₃Receptor Is Present in Different Subpopulations of GABAergic Neurons in the Rat Telencephalon

1997 • 363 citations

Neurochemistry and pharmacology of the major hippocampal transmitter systems: Synaptic and nonsynaptic interactions

1998 • 362 citations

Differential inhibitory effects of a 5-HT3 antagonist on drug-induced stimulation of dopamine release

1989 • 277 citations

5-HT3 receptors mediate rapid responses in cultured hippocampus and a clonal cell line

1988 • 261 citations

5-HT3 receptors mediate inhibition of acetylcholine release in cortical tissue

1989 • 259 citations

Activation of Serotonin Receptors Modulates Synaptic Transmission in Rat Cerebral Cortex

1999 • 241 citations

Release of endogenous dopamine by stimulation of 5-hydroxytryptamine3 receptors in rat striatum.

1989 • 238 citations

Central 5-HT4 receptors

1995 • 235 citations

Serotonin facilitates GABAergic transmission in the CA1 region of rat hippocampus in vitro.

1991 • 231 citations

Four Pharmacologically Distinct Subtypes of α4β2 Nicotinic Acetylcholine Receptor Expressed inXenopus laevisOocytes

1998 • 207 citations

Fast Synaptic Signaling by Nicotinic Acetylcholine and Serotonin 5-HT₃Receptors in Developing Visual Cortex

1997 • 194 citations

5-hydroxytryptamine is a fast excitatory transmitter at 5-HT3 receptors in rat amygdala

1992 • 192 citations

Serotonin microinfusion into the ventral tegmental area increases accumbens dopamine release

1989 • 191 citations

5-HT3 receptor binding sites are on capsaicin-sensitive fibres in the rat spinal cord

1989 • 184 citations

Carrier‐dependent and Ca²⁺‐dependent 5‐HT and dopamine release induced by (+)‐amphetamine, 3,4‐methylendioxy‐methamphetamine, p‐chloroamphetamine and (+)‐fenfluramine

1997 • 175 citations

Ligand- and voltage-gated ion channels

1995 • 171 citations

Localisation by autoradiography of neuronal 5-HT3 receptors in the mouse CNS

1988 • 164 citations

Activation of a 5-HT3 receptor releases dopamine from rat striatal slice

1988 • 163 citations

5-HT3 receptors in the rat central nervous system are mainly located on nerve fibres and terminals

1993 • 162 citations

Activation and blocking of neuronal nicotinic acetylcholine receptor reconstituted in Xenopus oocytes.

1990 • 157 citations

5-HT3 receptors control dopamine release in the nucleus accumbens of freely moving rats

1989 • 153 citations

Cloning and fnctional expression of an apparent splice variant of the murine 5-HT3 receptor A subunit

1993 • 147 citations

Opposite change of in vivo dopamine release in the rat nucleus accumbens and striatum that follows electrical stimulation of dorsal raphe nucleus: role of 5-HT3 receptors.

1998 • 143 citations

Hippocampal Interneurons Are Excited Via Serotonin-Gated Ion Channels

1997 • 141 citations

Actions of 5-hydroxytryptamine on ventral tegmental area neurons of the rat in vitro

1994 • 138 citations

Central and peripheral 5-HT3 receptors

1992 • 137 citations

Evidence for 5-HT4 receptor subtype involvement in the enhancement of striatal dopamine release induced by serotonin: a microdialysis study in the halothane-anesthetized rat

1995 • 136 citations

Ultrastructure of the 5‐Hydroxytryptamine₃ Receptor

1995 • 132 citations

Single amino acid substitution affects desensitization of the 5-hydroxytryptamine type 3 receptor expressed in Xenopus oocytes.

1993 • 130 citations

The properties of 5‐HT₃ receptors in clonal cell lines studied by patch‐clamp techniques

1989 • 129 citations

5-Hydroxytryptamine2 receptor facilitates GABAergic neurotransmission in rat hippocampus.

1998 • 124 citations

Pharmacological characterization of serotonin 5-HT3 receptor-mediated electrical response in cultured mouse neuroblastoma cells

1988 • 110 citations

Serotonergic Facilitation of Acetylcholine Release In Vivo from Rat Dorsal Hippocampus via Serotonin 5‐HT₃ Receptors

1994 • 106 citations

Opposing roles for 5‐HT_1B and 5‐HT₃ receptors in the control of 5‐HT release in rat hippocampus in vivo

1992 • 106 citations

Distribution and functional properties of 5-HT3 receptors in the rat hippocampal dentate gyrus: a patch-clamp study

1994 • 100 citations

Cholecystokinin release mediated by 5‐HT₃ receptors in rat cerebral cortex and nucleus accumbens

1991 • 97 citations

High Calcium Permeability of Serotonin 5‐HT₃ Receptors on Presynaptic Nerve Terminals from Rat Striatum

1998 • 96 citations

Inhibition by steroids of [14C]-guanidinium flux through the voltage-gated sodium channel and the cation channel of the 5-HT3 receptor of N1E-115 neuroblastoma cells

1999 • 92 citations

Ondansetron Exhibits the Properties of a Local Anesthetic

1997 • 92 citations

The Role of Tryptophan Residues in the 5-Hydroxytryptamine3 Receptor Ligand Binding Domain

2000 • 91 citations

Serotonin-stimulated release of [3H]dopamine via reversal of the dopamine transporter in rat striatum and nucleus accumbens: a comparison with release elicited by potassium, N-methyl-D-aspartic acid, glutamic acid and D-amphetamine.

1992 • 86 citations

Serotonin (5-HT) enhances hippocampal noradrenaline (NA) release: Evidence for facilitatory 5-HT receptors within the CNS

1986 • 85 citations

Evidence for presynaptic 5-hydroxytryptamine3 recognition sites on vagal afferent terminals in the brainstem of the ferret

1990 • 77 citations

Analysis of the Ligand Binding Site of the 5-HT 3 Receptor Using Site Directed Mutagenesis: Importance of Glutamate 106

1997 • 77 citations

Baroreceptor reflex inhibition induced by the stimulation of serotonin3 receptors in the nucleus tractus solitarius of the rat

1992 • 75 citations

Serotonergic modulation of the release of endogenous norepinephrine from rat hypothalamic slices.

1991 • 71 citations

Direct Observation of Serotonin 5‐HT₃ Receptor‐Induced Increases in Calcium Levels in Individual Brain Nerve Terminals

1996 • 69 citations

Calcium changes induced by presynaptic 5-hydroxytryptamine-3 serotonin receptors on isolated terminals from various regions of the rat brain

1999 • 69 citations

Ventral tegmental area 5-HT receptors: mesolimbic dopamine release and behavioural studies

1995 • 68 citations

Involvement of GABA systems in acetylcholine release induced by 5-HT3 receptor blockade in slices from rat entorhinal cortex

1996 • 66 citations

Regulation of striatal dopamine release through 5-HT1 and 5-HT2 receptors

1999 • 64 citations

Allosteric modulation of 5-HT3 receptors: focus on alcohols and anaesthetic agents

1996 • 62 citations

5-HT1B receptors modulate release of [3H]dopamine from rat striatal synaptosomes

1999 • 57 citations

The putative 5-HT3 agonist phenylbiguanide induces carrier-mediated release of [3H]dopamine

1989 • 57 citations

The dopamine response in mouse neuroblastoma cells is mediated by serotonin 5HT3 receptors

1986 • 56 citations

Promiscuous coassembly of serotonin 5-HT ₃ and nicotinic α4 receptor subunits into Ca ²⁺ -permeable ion channels

1998 • 56 citations

Activation of 5-HT3 receptors enhances the electrically evoked release of [3H]noradrenaline in rat brain limbic structures

1994 • 56 citations

Developmental Changes in the Differential Expression of Two Serotonin 5‐HT₃ Receptor Splice Variants in the Rat

1995 • 55 citations

Characteristics of [¹⁴C]Guanidinium Accumulation in NG 108‐15 Cell Exposed to Serotonin 5‐HT₃ Receptor Ligands and Substance P

1993 • 55 citations

Selection of distinct conformational states of the 5‐HT₃ receptor by full and partial agonists

1996 • 54 citations

5-Hydroxytryptamine-3 receptors modulate synaptic activity in the rat nucleus tractus solitarius in vitro

1992 • 53 citations

Effects of 5-HT3 receptor antagonists on binding and function of mouse and human GABAA receptors

1994 • 44 citations

Role of 5‐HT₃ receptors in basal and K⁺‐evoked dopamine release from rat olfactory tubercle and striatal slices

1994 • 43 citations

5-Hydroxytryptamine antagonist ICS 205-930 blocks cardiac potassium, sodium and calcium currents.

1988 • 41 citations

THE EFFECTS OF 5‐HYDROXYTRYPTOPHAN AND 5‐HYDROXYTRYPTAMINE ON DOPAMINE SYNTHESIS AND RELEASE IN RAT BRAIN STRIATAL SYNAPTOSOMES¹

1978 • 39 citations

Dopamine releasing effect of phenylbiguanide in rat striatal slices

1992 • 39 citations

Effect of cocaine and 5-HT3 receptor antagonists on 5-HT=indeced [5H]dopamine release from rat striatal synaptosomes

1991 • 39 citations

Feedback Stimulation of Somatodendritic Serotonin Release: A 5-HT3 Receptor-Mediated Effect in the Raphe Nuclei of the Rat

1998 • 37 citations

Pre‐ and post‐synaptic effects of the 5‐HT₃ agonist 2‐Methyl‐5‐HT on the 5‐HT system in the rat brain

1995 • 36 citations

Stress‐ and Yohimbine‐Induced Release of Cholecystokinin in the Frontal Cortex of the Freely Moving Rat: Prevention by Diazepam but Not Ondansetron

1996 • 33 citations

5-HT3 receptor ligands lack modulatory influence on acetycholine release in rat entorhinal cortex

1993 • 32 citations

Inhibitory effect of ondansetron on glycine response of dissociated rat hippocampal neurons.

1999 • 32 citations

5‐HT₃ receptor agonist induced carrier‐mediated release of dopamine in rat striatum in vivo

1995 • 30 citations

5-HT 3 SEROTONIN HETERO-RECEPTORS INHIBIT [ 3 H]ACETHYLCHOLINE RELEASE IN RAT CORTICAL SYNAPTOSOMES

1997 • 28 citations

Biguanide derivatives: agonist pharmacology at 5-hydroxytryptamine type 3 receptors in vitro.

1994 • 27 citations

Identification of a domain affecting agonist potency of meta-chlorophenylbiguanide in 5-HT3 receptors

1999 • 25 citations

5‐HT₃ receptors which modulate [³H]5‐HT release in the guinea pig hypothalamus are not autoreceptors

1993 • 23 citations

The 5-HT3 receptor agonist 1-(m-chlorophenyl)-biguanide interacts with the dopamine transporter in rat brain synaptosomes

1995 • 21 citations

GABA augments basal and electrically stimulated 3H-norepinephrine release in hypothalamic, preoptic area and cortical slices of female rats

1997 • 20 citations

Differentiation Alters the Expression of the Two Splice Variants of the Serotonin 5‐HT₃ Receptor‐A mRNA in NG108‐15 Cells

1995 • 20 citations

Effects of 5‐HT receptor agonists on depolarization‐induced [³H]‐noradrenaline release in rabbit hippocampus and human neocortex

1995 • 20 citations

The 5-HT3 receptor agonist 1-(m-chlorophenyl)-biguanide facilitates noradrenaline release by blockade of ?2-adrenoceptors in the mouse brain cortex

1994 • 20 citations

Native Serotonin 5‐HT₃ Receptors Expressed in Xenopus Oocytes Differ from Homopentameric 5‐HT₃ Receptors

1997 • 18 citations

Clozapine's antipsychotic effects do not depend on blockade of 5-HT3 receptors.

1999 • 16 citations

The 5-HT3 Receptor Channel: Function, Activation and Regulation

2000 • 15 citations

The effect of 5-HT3 receptor antagonists on the morphine-induced excitation of A10 dopamine cells: electrophysiological studies

1994 • 13 citations

Inhibition of [³H] γ‐aminobutyric acid release from guinea‐pig hippocampal synaptosomes by serotonergic agents

1992 • 11 citations