The 5-HT3 Receptor Channel: Function, Activation and Regulation

A study of the ‘desensitization’ produced by acetylcholine at the motor end‐plate

1957 • 1,457 citations

Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamine

1986 • 1,255 citations

Primary Structure And Functional Expression of the 5HT ₃ Receptor, A Serotonin-gated Ion Channel

1991 • 976 citations

Identification and distribution of 5-HT3 receptors in rat brain using radioligand binding

1987 • 866 citations

TWO KINDS OF TRYPTAMINE RECEPTOR

1957 • 838 citations

5-HT3 receptors are membrane ion channels

1989 • 630 citations

The 5-HT3B subunit is a major determinant of serotonin-receptor function

1999 • 555 citations

GABAA receptor needs two homologous domains of the & beta;-subunit for activation by GABA but not by pentobarbital

1993 • 417 citations

Chimaeric nicotinic–serotonergic receptor combines distinct ligand binding and channel specificities

1993 • 401 citations

The 5-HT₃Receptor Is Present in Different Subpopulations of GABAergic Neurons in the Rat Telencephalon

1997 • 363 citations

Serotonergic control of the hippocampus via local inhibitory interneurons.

1990 • 355 citations

Amino acids of the Torpedo marmorata acetylcholine receptor .alpha. subunit labeled by a photoaffinity ligand for the acetylcholine binding site

1988 • 314 citations

5-HT3 receptors mediate rapid responses in cultured hippocampus and a clonal cell line

1988 • 261 citations

5-HT3 receptors mediate inhibition of acetylcholine release in cortical tissue

1989 • 259 citations

Release of endogenous dopamine by stimulation of 5-hydroxytryptamine3 receptors in rat striatum.

1989 • 238 citations

Serotonin facilitates GABAergic transmission in the CA1 region of rat hippocampus in vitro.

1991 • 231 citations

Effects of 5-HT3 receptor antagonism on hippocampal theta rhythm, memory, and LTP induction in the freely moving rat

1995 • 219 citations

Fast Synaptic Signaling by Nicotinic Acetylcholine and Serotonin 5-HT₃Receptors in Developing Visual Cortex

1997 • 194 citations

5-hydroxytryptamine is a fast excitatory transmitter at 5-HT3 receptors in rat amygdala

1992 • 192 citations

1-(m-Chlorophenyl)-biguanide, a potent high affinity 5-HT3 receptor agonist

1990 • 188 citations

Ion-channel assembly.

1995 • 181 citations

The 5-HT3 Receptor Channel

1995 • 180 citations

Molecular cloning of human 5-hydroxytryptamine3 receptor: heterogeneity in distribution and function among species.

1995 • 179 citations

5-HT3 receptors in the rat central nervous system are mainly located on nerve fibres and terminals

1993 • 162 citations

Cloning and fnctional expression of an apparent splice variant of the murine 5-HT3 receptor A subunit

1993 • 147 citations

Mutation of Glycine Receptor Subunit Creates β-Alanine Receptor Responsive to GABA

1993 • 147 citations

Hippocampal Interneurons Are Excited Via Serotonin-Gated Ion Channels

1997 • 141 citations

Distinct agonist- and antagonist-binding sites on the glycine receptor

1992 • 132 citations

Ultrastructure of the 5‐Hydroxytryptamine₃ Receptor

1995 • 132 citations

Behavioural pharmacology of 5-HT3 receptor antagonists: a critical update on therapeutic potential

1993 • 131 citations

Single amino acid substitution affects desensitization of the 5-hydroxytryptamine type 3 receptor expressed in Xenopus oocytes.

1993 • 130 citations

Ion permeation through 5-hydroxytryptamine-gated channels in neuroblastoma N18 cells.

1990 • 125 citations

Alcohols and anesthetics enhance the function of 5-hydroxytryptamine3 receptors expressed in Xenopus laevis oocytes.

1994 • 119 citations

Cloning and functional expression of a human 5-hydroxytryptamine type 3AS receptor subunit.

1995 • 117 citations

5‐Hydroxytryptamine₃ Receptors Sited on Cholinergic Axon Terminals of Human Cerebral Cortex Mediate Inhibition of Acetylcholine Release

1992 • 113 citations

The role of 5-HT3 receptors in drug dependence

1995 • 112 citations

Pharmacological characterization of serotonin 5-HT3 receptor-mediated electrical response in cultured mouse neuroblastoma cells

1988 • 110 citations

The pharmacological characterization of 5‐HT₃ receptors in three isolated preparations derived from guinea‐pig tissues

1990 • 110 citations

Ion permeation and conduction in a human recombinant 5‐HT₃ receptor subunit (h5‐HT_3A)

1998 • 109 citations

Functional properties of a cloned 5‐hydroxytryptamine ionotropic receptor subunit: comparison with native mouse receptors.

1994 • 101 citations

Distribution and functional properties of 5-HT3 receptors in the rat hippocampal dentate gyrus: a patch-clamp study

1994 • 100 citations

Cholecystokinin release mediated by 5‐HT₃ receptors in rat cerebral cortex and nucleus accumbens

1991 • 97 citations

High Calcium Permeability of Serotonin 5‐HT₃ Receptors on Presynaptic Nerve Terminals from Rat Striatum

1998 • 96 citations

5-HT3 receptor channels in dissociated rat superior cervical ganglion neurons.

1992 • 91 citations

The Role of Tryptophan Residues in the 5-Hydroxytryptamine3 Receptor Ligand Binding Domain

2000 • 91 citations

Actions of general anaesthetics on 5‐HT₃ receptors in N1E‐115 neuroblastoma cells

1996 • 90 citations

Molecular Cloning, Functional Expression, and Pharmacological Characterization of 5-Hydroxytryptamine₃ Receptor cDNA and Its Splice Variants from Guinea Pig

1998 • 90 citations

Ca2+ permeability of cloned and native 5-hydroxytryptamine type 3 receptors.

1994 • 88 citations

Structural Features of the Ligand-binding Domain of the Serotonin 5HT3 Receptor

1999 • 85 citations

An electrophysiological investigation of the properties of a murine recombinant 5‐HT₃ receptor stably expressed in HEK 293 cells

1995 • 80 citations

Analysis of the Ligand Binding Site of the 5-HT 3 Receptor Using Site Directed Mutagenesis: Importance of Glutamate 106

1997 • 77 citations

Kinetics of the membrane current mediated by serotonin 5‐HT3 receptors in cultured mouse neuroblastoma cells.

1989 • 76 citations

Alcohols potentiate the function of 5‐HT₃ receptor‐channels on NCB‐20 neuroblastoma cells by favouring and stabilizing the open channel state

1998 • 74 citations

Organization of the mouse 5-HT3 receptor gene and functional expression of two splice variants

1994 • 73 citations

Direct Observation of Serotonin 5‐HT₃ Receptor‐Induced Increases in Calcium Levels in Individual Brain Nerve Terminals

1996 • 69 citations

Evidence that the 5‐HT₃ receptors of the rat, mouse and guinea‐pig superior cervical ganglion may be different

1991 • 69 citations

Desperately seeking subunits: are native 5-HT3 receptors really homomeric complexes?

1998 • 65 citations

Activation and desensitization of the 5‐HT3 receptor in a rat glioma x mouse neuroblastoma hybrid cell.

1991 • 65 citations

Allosteric modulation of 5-HT3 receptors: focus on alcohols and anaesthetic agents

1996 • 62 citations

5-HT 3 receptor over-expression decreases ethanol self administration in transgenic mice

1998 • 61 citations

Promiscuous coassembly of serotonin 5-HT ₃ and nicotinic α4 receptor subunits into Ca ²⁺ -permeable ion channels

1998 • 56 citations

Developmental Changes in the Differential Expression of Two Serotonin 5‐HT₃ Receptor Splice Variants in the Rat

1995 • 55 citations

5-Hydroxytryptamine-3 receptors modulate synaptic activity in the rat nucleus tractus solitarius in vitro

1992 • 53 citations

Pharmacological characterization of the apparent splice variants of the murine 5-HT3 R-A subunit expressed in Xenopus laevis oocytes

1994 • 49 citations

Pharmacologic characteristics of potentiation of 5-HT3 receptors by alcohols and diethyl ether in NCB-20 neuroblastoma cells.

1996 • 47 citations

Phosphorylation controls conductance of 5-HT3 receptor ligand-gated ion channels.

1995 • 45 citations

Effects of 5-HT₃ Receptor Antagonism on Hippocampal Cellular Activity in the Freely Moving Rat

1997 • 45 citations

Pharmacological Characterization of 5‐Hydroxytryptamine₃Receptors in Murine Brain and Ileum Using the Novel Radioligand [³H]RS‐42358–197: Evidence for Receptor Heterogeneity

1993 • 43 citations

Induction and maintenance of ganglionic long‐term potentiation require activation of 5‐hydroxytryptamine (5‐HT3) receptors.

1996 • 40 citations

5-HT3 receptors induce rises in cytosolic and nuclear calcium in NG108-15 cells via calciumm-induced calcium release

1997 • 39 citations

Organisation of the murine 5‐HT₃ receptor gene and assignment tohuman chromosome 11

1994 • 36 citations

Differentiation of NG108-15 cells alters channel conductance and desensitization kinetics of the 5-HT3 receptor

1991 • 35 citations

Potentiation of 5-HT3 receptor-mediated responses by protein kinase C activation

1995 • 35 citations

Allosteric Potentiation of the 5-HT 3 Receptor-mediated Ion Current in N1E-115 Neuroblastoma Cells by 5-Hydroxyindole and Analogues

1997 • 34 citations

5‐Hydroxyindole slows desensitization of the 5‐HT₃ receptor‐mediated ion current in N1E‐115 neuroblastoma cells

1993 • 32 citations

Immunological Characterization and Transmembrane Topology of 5‐Hydroxytryptamine₃ Receptors by Functional Epitope Tagging

1996 • 31 citations

Competitive and non‐competitive effects of 5‐hydroxyindole on 5‐HT₃ receptors in N1E‐115 neuroblastoma cells

1994 • 28 citations

Biguanide derivatives: agonist pharmacology at 5-hydroxytryptamine type 3 receptors in vitro.

1994 • 27 citations

Purification of 5‐hydroxytryptamine₃ receptors from porcine brain

1997 • 26 citations

The Nicotinic α4 Receptor Subunit Contributes to the Lining of the Ion Channel Pore When Expressed with the 5-HT3 Receptor Subunit

1999 • 25 citations

Electrophysiological consequences of ligand binding to the desensitized 5‐HT3 receptor in mammalian NG108‐15 cells.

1996 • 24 citations

Modulation by calcineurin of 5‐HT₃receptor function in NG108‐15 neuroblastoma x glioma cells

1996 • 24 citations

Different efficacy of specific agonists at 5‐HT₃ receptor splice variants: the role of the extra six amino acid segment

1998 • 23 citations

Ketamine potentiates 5‐HT₃ receptor‐mediated currents in rabbit nodose ganglion neurones

1991 • 21 citations

Differentiation Alters the Expression of the Two Splice Variants of the Serotonin 5‐HT₃ Receptor‐A mRNA in NG108‐15 Cells

1995 • 20 citations

Functional characterization of two 5-HT3 receptor splice variants isolated from a mouse hippocampal cell line

1996 • 19 citations

Tetraethylammonium ions block 5-HT3 receptor-mediated ion current at the agonist recognition site and prevent desensitization in cultured mouse neuroblastoma cells

1993 • 18 citations

Native Serotonin 5‐HT₃ Receptors Expressed in Xenopus Oocytes Differ from Homopentameric 5‐HT₃ Receptors

1997 • 18 citations

Ca²⁺ influx through voltage‐gated Ca²⁺ channels regulates 5‐HT₃ receptor channel desensitization in rat glioma × mouse neuroblastoma hybrid NG108–15 cells

1998 • 18 citations

Involvement of tryptophan residue(s) in the specific binding of agonists/antagonists to 5-HT3 receptors in NG108-15 clonal cells

1991 • 16 citations

Activation of 5-HT3 receptors expressed in Xenopus oocytes does not increase cytoplasmic Ca2+ levels.

1995 • 14 citations

Single 5-HT3 Receptor-Gated Ion Channel Events Resolved in N1E-115 Mouse Neuroblastoma Cells

1994 • 9 citations

Comparison of fast responses to serotonin and 2-methyl-serotonin in voltage-clamped N1E-115 neuroblastoma cells

1991 • 4 citations

Communications

1996 • 1 citations