Structural Basis of G Protein Specificity of Human Endothelin Receptors

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

1988 • 10,786 citations

Cloning and expression of a cDNA encoding an endothelin receptor

1990 • 2,590 citations

The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes.

1989 • 2,551 citations

Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor

1990 • 2,432 citations

Differential signal transduction by five splice variants of the PACAP receptor

1993 • 1,185 citations

Chimeric α ₂ -,β ₂ -Adrenergic Receptors: Delineation of Domains Involved in Effector Coupling and Ligand Binding Specificity

1988 • 766 citations

Biochemical and pharmacological profile of a potent and selective endothelin B-receptor antagonist, BQ-788.

1994 • 574 citations

Alternative splicing of C-terminal tail of prostaglandin E receptor subtype EP3 determines G-protein specificity

1993 • 546 citations

The molecular basis of muscarinic receptor diversity

1989 • 544 citations

A novel vasoactive peptide endothelin stimulates mitogenesis through inositol lipid turnover in Swiss 3T3 fibroblasts

1989 • 485 citations

Structural elements of Gα subunits that interact with Gβγ, receptors, and effectors

1993 • 417 citations

Three cytoplasmic loops of rhodopsin interact with transducin.

1989 • 370 citations

Signal sorting and amplification through G protein-coupled receptors

1989 • 338 citations

Cloning and expression of human endothelin‐1 receptor cDNA

1991 • 282 citations

Cloning and functional expression of human cDNA for the ETB endothelin receptor

1991 • 273 citations

Distinct tissue distribution and cellular localization of two messenger ribonucleic acids encoding different subtypes of rat endothelin receptors.

1992 • 273 citations

Mutations that uncouple the beta-adrenergic receptor from Gs and increase agonist affinity.

1987 • 259 citations

Chimeric muscarinic cholinergic: beta-adrenergic receptors that activate Gs in response to muscarinic agonists.

1990 • 230 citations

Coupling of two endothelin receptor subtypes to differing signal transduction in transfected Chinese hamster ovary cells.

1992 • 207 citations

Detection of G protein-activator regions in M4 subtype muscarinic, cholinergic, and alpha 2-adrenergic receptors based upon characteristics in primary structure.

1992 • 201 citations

Distinct sequence elements control the specificity of G protein activation by muscarinic acetylcholine receptor subtypes.

1990 • 192 citations

Distinct subdomains of human endothelin receptors determine their selectivity to endothelinA-selective antagonist and endothelinB-selective agonists.

1993 • 168 citations

Location of a region of the muscarinic acetylcholine receptor involved in selective effector coupling

1988 • 167 citations

Endothelin-A receptor mediates cardiac inhibition by regulating calcium and potassium currents

1994 • 152 citations

Delineation of muscarinic receptor domains conferring selectivity of coupling to guanine nucleotide-binding proteins and second messengers.

1990 • 132 citations

Inhibition of the cardiac protein kinase A-dependent chloride conductance by endothelin-1

1994 • 90 citations

Endothelin receptor subtypes are coupled to adenylate cyclase via different guanyl nucleotide-binding proteins in vasculature.

1993 • 83 citations

Pharmacological characterization of a potent nonpeptide endothelin receptor antagonist, 97-139.

1994 • 51 citations

Endothelin stimulates both cAMP formation and phosphatidylinositol hydrolysis in cultured embryonic bovine tracheal cells

1992 • 42 citations

Domains of muscarinic acetylcholine receptors that confer specificity of G protein coupling

1992 • 33 citations

Endothelin- and ATP-induced inhibition of adenylyl cyclase activity in C6 glioma cells: role of Gi and calcium.

1993 • 27 citations