Towards a complete map of the protein space based on a unified sequence and structure analysis of all known proteins.

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

1997 • 71,835 citations

Pattern classification and scene analysis

1973 • 12,976 citations

Information Theory and Statistical Mechanics

1957 • 12,269 citations

Information theory and statistics

1959 • 7,634 citations

Amino acid substitution matrices from protein blocks.

1992 • 5,998 citations

Divergence measures based on the Shannon entropy

1991 • 4,240 citations

Statistics of extremes

1958 • 4,080 citations

A Genomic Perspective on Protein Families

1997 • 3,531 citations

CATH – a hierarchic classification of protein domain structures

1997 • 2,558 citations

The PROSITE database, its status in 1997

1997 • 1,783 citations

Mapping the Protein Universe

1996 • 1,508 citations

The PROSITE database, its status in 1999

1999 • 1,109 citations

OB(oligonucleotide/oligosaccharide binding)-fold: common structural and functional solution for non-homologous sequences.

1993 • 917 citations

Sequence comparisons using multiple sequences detect three times as many remote homologues as pairwise methods

1998 • 560 citations

Assessing sequence comparison methods with reliable structurally identified distant evolutionary relationships

1998 • 532 citations

Pfam 3.1: 1313 multiple alignments and profile HMMs match the majority of proteins

1999 • 511 citations

Amino acid substitution matrices

2000 • 459 citations

Performance evaluation of amino acid substitution matrices

1993 • 448 citations

Potential energy function and parameters for simulations of the molecular dynamics of proteins and nucleic acids in solution

1995 • 435 citations

Dali/FSSP classification of three-dimensional protein folds

1997 • 423 citations

The theory and practice of distance geometry

1983 • 377 citations

Comparison of methods for searching protein sequence databases

1995 • 344 citations

A unified statistical framework for sequence comparison and structure comparison

1998 • 303 citations

Comprehensive assessment of automatic structural alignment against a manual standard, the scop classification of proteins

1998 • 224 citations

Searching databases of conserved sequence regions by aligning protein multiple-alignments [published erratum appears in Nucleic Acids Res 1996 Nov 1;24(21):4372]

1996 • 223 citations

Recent improvements of the ProDom database of protein domain families

1999 • 166 citations

Microbial genomes opened up

1998 • 139 citations

Optimal alignment between groups of sequences and its application to multiple sequence alignment

1993 • 130 citations

PRINTS prepares for the new millennium

1999 • 129 citations

ProtoMap: Automatic classification of protein sequences, a hierarchy of protein families, and local maps of the protein space

1999 • 112 citations

New features of the Blocks Database servers

1999 • 101 citations

Genetics and Properties of Cellulases

1999 • 93 citations

SAM: SEQUENCE ALIGNMENT AND MODELING SOFTWARE SYSTEM

1995 • 89 citations

Metrics and similarity measures for hidden Markov models.

1999 • 70 citations

Identifying distantly related protein sequences

1997 • 55 citations

Agnostic Classification of Markovian Sequences

1997 • 38 citations

Multidimensional scaling by deterministic annealing

1997 • 34 citations

Microbial Genomes Come Tumbling In

1997 • 15 citations