Sequence comparisons using multiple sequences detect three times as many remote homologues as pairwise methods

Basic local alignment search tool

1990 • 87,358 citations

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

1997 • 71,835 citations

Improved tools for biological sequence comparison.

1988 • 11,455 citations

SCOP: A structural classification of proteins database for the investigation of sequences and structures

1995 • 6,372 citations

Hidden Markov Models in Computational Biology

1994 • 1,954 citations

Hidden Markov models

1996 • 1,313 citations

Profile analysis: detection of distantly related proteins.

1987 • 1,308 citations

[27] Local alignment statistics

1996 • 729 citations

Untitled

1995 • 545 citations

Assessing sequence comparison methods with reliable structurally identified distant evolutionary relationships

1998 • 532 citations

Determinants of a protein fold

1987 • 498 citations

[9] Profile analysis

1990 • 486 citations

Hidden Markov models of biological primary sequence information.

1994 • 465 citations

Hidden Markov models for sequence analysis: extension and analysis of the basic method

1996 • 448 citations

Dirichlet mixtures: a method for improved detection of weak but significant protein sequence homology

1996 • 338 citations

Removing near-neighbour redundancy from large protein sequence collections.

1998 • 306 citations

Improved sensitivity of profile searches through the use of sequence weights and gap excision

1994 • 301 citations

Detection of conserved segments in proteins: iterative scanning of sequence databases with alignment blocks.

1994 • 286 citations

Identification of protein sequence homology by consensus template alignment

1986 • 283 citations

Maximum Discrimination Hidden Markov Models of Sequence Consensus

1995 • 248 citations

Extracting protein alignment models from the sequence database

1997 • 243 citations

How far divergent evolution goes in proteins

1998 • 236 citations

Intermediate sequences increase the detection of homology between sequences

1997 • 225 citations

Predicting protein structure using hidden Markov models

1997 • 156 citations

Improving the sensitivity of the sequence profile method

1994 • 118 citations

Recognition of related proteins by iterative template refinement (ITR)

1994 • 46 citations