Insulin Internalization into Monocytes Is Decreased in Patients with Type II Diabetes Mellitus*

Receptor and postreceptor defects contribute to the insulin resistance in noninsulin-dependent diabetes mellitus.

1981 • 628 citations

Transglutaminase is essential in receptor-mediated endocytosis of α2-macroglobulin and polypeptide hormones

1980 • 535 citations

Insulin-induced receptor loss in cultured human lymphocytes is due to accelerated receptor degradation.

1981 • 217 citations

Phagocytosis by Human Monocytes

1968 • 208 citations

The fate of insulin bound to adipocytes. Evidence for compartmentalization and processing.

1978 • 189 citations

Cellular uptake and nuclear binding of insulin in human cultured lymphocytes: evidence for potential intracellular sites of insulin action.

1977 • 171 citations

Insulin radioreceptor assay for human erythrocytes.

1977 • 169 citations

Surface binding and rates of internalization of 125I-insulin in adipocytes and IM-9 lymphocytes.

1982 • 116 citations

Evidence for insulin-induced internalization and degradation of insulin receptors in rat adipocytes.

1982 • 105 citations

Biochemical and morphological evidence that the insulin receptor is internalized with insulin in hepatocytes.

1982 • 102 citations

Endocytosis of Peptide Hormones and Other Ligands

1982 • 90 citations

The monocyte as a model for the study of insulin receptors in man

1977 • 85 citations

Insulin secretion and insulin action in non-insulin-dependent diabetes mellitus: which defect is primary?

1984 • 84 citations

Mechanisms of insulin resistance in man

1981 • 81 citations

Kinetic Analysis of Plasma Insulin Disappearance in Nonketotic Diabetic Patients and in Normal Subjects

1978 • 80 citations

The Pathogenic Role of an Insulin-receptor Defect in Diabetes Mellitus of the Obese

1978 • 80 citations

Inhibition of intracellular proteolysis by insulin in isolated rat hepatocytes. Possible role of internalized hormone.

1982 • 77 citations

Postreceptor Defects Causing Insulin Resistance in Normoinsulinemic Non-insulin-dependent Diabetes Mellitus

1982 • 67 citations

Interaction of insulin, polypeptide hormones, and growth factors with intracellular membranes

1981 • 64 citations

Selective Effects of Inhibitors of Hormone Processing on Insulin Action in Isolated Hepatocytes*

1984 • 63 citations

Insulin receptors and the site of action of insulin

1978 • 62 citations

Insulin regulation of protein phosphorylation in isolated rat liver nuclear envelopes: potential relationship to mRNA metabolism.

1983 • 60 citations

Receptor mediated endocytosis of polypeptide hormones: Mechanism and significance

1982 • 51 citations

Insulin Binding, Internalization, and Insulin Receptor Regulation in Fibroblasts from Type II, Non-insulin-dependent Diabetic Subjects

1981 • 48 citations

The Insulin Receptor of a Human Monocyte-Like Cell Line: Characterization and Function*

1984 • 41 citations

Effects of monensin on insulin processing in adipocytes. Evidence that the internalized insulin-receptor complex has some physiological activities.

1985 • 40 citations

Insulin Degradation by Mononuclear Cells

1980 • 36 citations

Insulin-ricin B chain conjugate. A hybrid molecule with ricin-binding activity and insulin biological activity.

1981 • 24 citations

Receptors for Peptide Hormones: Alterations in Diseases of Humans

1982 • 20 citations

Insulin action in pancreatic acini from streptozotocin-treated rats. III. Electron microscope autoradiography of 125I-insulin

1981 • 19 citations