Antitumor Efficacy of Intermittent Treatment Schedules with the Rapamycin Derivative RAD001 Correlates with Prolonged Inactivation of Ribosomal Protein S6 Kinase 1 in Peripheral Blood Mononuclear Cells

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

2002 • 2,945 citations

mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

2002 • 2,904 citations

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

2003 • 1,803 citations

Raptor, a Binding Partner of Target of Rapamycin (TOR), Mediates TOR Action

2002 • 1,758 citations

Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor

2002 • 1,717 citations

Regulation of translation initiation by FRAP/mTOR

2001 • 1,532 citations

Amino Acid Sufficiency and mTOR Regulate p70 S6 Kinase and eIF-4E BP1 through a Common Effector Mechanism

1998 • 1,319 citations

Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism

1999 • 1,255 citations

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

1992 • 1,146 citations

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

1998 • 1,136 citations

Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E

2002 • 1,064 citations

Insulin Activation of Rheb, a Mediator of mTOR/S6K/4E-BP Signaling, Is Inhibited by TSC1 and 2

2003 • 1,015 citations

Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR

2001 • 981 citations

Phosphorylation of the Translational Repressor PHAS-I by the Mammalian Target of Rapamycin

1997 • 953 citations

Mammalian TOR: A Homeostatic ATP Sensor

2001 • 936 citations

Akt regulates growth by directly phosphorylating Tsc2

2002 • 932 citations

Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k

1997 • 930 citations

Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation

1999 • 928 citations

GβL, a Positive Regulator of the Rapamycin-Sensitive Pathway Required for the Nutrient-Sensitive Interaction between Raptor and mTOR

2003 • 927 citations

A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells.

2000 • 713 citations

Ribosomal S6 Kinase Signaling and the Control of Translation

1999 • 679 citations

The Mammalian Target of Rapamycin (mTOR) Partner, Raptor, Binds the mTOR Substrates p70 S6 Kinase and 4E-BP1 through Their TOR Signaling (TOS) Motif

2003 • 644 citations

Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family.

1994 • 634 citations

The rapamycin-sensitive signal transduction pathway as a target for cancer therapy

2000 • 587 citations

An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity inPten^+/−mice

2001 • 574 citations

SDZ RAD, A NEW RAPAMYCIN DERIVATIVE

1997 • 533 citations

Synthesis of the translational apparatus is regulated at the translational level

2000 • 515 citations

TOS Motif-Mediated Raptor Binding Regulates 4E-BP1 Multisite Phosphorylation and Function

2003 • 501 citations

Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway

1998 • 487 citations

Identification of a Conserved Motif Required for mTOR Signaling

2002 • 472 citations

The principal target of rapamycin-induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain.

1995 • 441 citations

mTOR, a novel target in breast cancer: the effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer.

2001 • 421 citations

The Immunosuppressant Rapamycin Mimics a Starvation-Like Signal Distinct from Amino Acid and Glucose Deprivation

2002 • 394 citations

Rapamycin Inhibition of the G1 to S Transition Is Mediated by Effects on Cyclin D1 mRNA and Protein Stability

1998 • 338 citations

FKBP12-Rapamycin-associated Protein (FRAP) Autophosphorylates at Serine 2481 under Translationally Repressive Conditions

2000 • 338 citations

Activity of rapamycin (AY-22,989) against transplanted tumors.

1984 • 337 citations

Rapamycin causes poorly reversible inhibition of mTOR and induces p53-independent apoptosis in human rhabdomyosarcoma cells.

1999 • 313 citations

ErbB2 Potentiates Breast Tumor Proliferation through Modulation of p27^Kip1-Cdk2 Complex Formation: Receptor Overexpression Does Not Determine Growth Dependency

2000 • 304 citations

Antitumor activity of the rapamycin analog CCI-779 in human primitive neuroectodermal tumor/medulloblastoma models as single agent and in combination chemotherapy.

2001 • 263 citations

ErbB-1 and ErbB-2 Acquire Distinct Signaling Properties Dependent upon Their Dimerization Partner

1998 • 259 citations

FKBP12-rapamycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction

2002 • 243 citations

Branched-chain Amino Acids Are Essential in the Regulation of PHAS-I and p70 S6 Kinase by Pancreatic β-Cells

1998 • 236 citations

Enhanced sensitivity of multiple myeloma cells containing PTEN mutations to CCI-779.

2002 • 235 citations

Biochemical correlates of mTOR inhibition by the rapamycin ester CCI-779 and tumor growth inhibition.

2001 • 229 citations

The immunosuppressive macrolide RAD inhibits growth of human Epstein–Barr virus-transformed B lymphocytes in vitro and in vivo : A potential approach to prevention and treatment of posttransplant lymphoproliferative disorders

2000 • 215 citations

Regulation of cell growth and cyclin D1 expression by the constitutively active FRAP-p70s6K pathway in human pancreatic cancer cells.

1999 • 211 citations

Amino Acid-dependent Control of p70s6k

1999 • 205 citations

Inhibitors of mammalian target of rapamycin as novel antitumor agents: from bench to clinic.

2002 • 183 citations

Pharmacodynamic Evaluation of CCI-779, an Inhibitor of mTOR, in Cancer Patients.

2003 • 178 citations

Translational induction of the c-myc oncogene via activation of the FRAP/TOR signalling pathway

1998 • 177 citations

Human brain tumor xenografts in nude mice as a chemotherapy model

1983 • 162 citations

Immunosuppressive TOR kinase inhibitor everolimus (RAD) suppresses growth of cells derived from posttransplant lymphoproliferative disorder at allograft-protecting doses

2003 • 157 citations

Mammalian Target of Rapamycin: A New Molecular Target for Breast Cancer

2003 • 140 citations

Exposure-response relationships for everolimus in de novo kidney transplantation: defining a therapeutic range

2002 • 139 citations

Mammalian Target of Rapamycin-dependent Phosphorylation of PHAS-I in Four (S/T)P Sites Detected by Phospho-specific Antibodies

2000 • 133 citations

Sanglifehrin A, a Novel Cyclophilin-Binding Compound Showing Immunosuppressive Activity with a New Mechanism of Action

2001 • 104 citations

Failure of rapamycin to block proliferation once resting cells have entered the cell cycle despite inactivation of p70 S6 kinase

1993 • 82 citations

Rapamycin-insensitive Regulation of 4E-BP1 in Regenerating Rat Liver

2001 • 82 citations

Early Clinical Experience With a Novel Rapamycin Derivative

2002 • 77 citations

Immunophilins, mTOR, and pharmacodynamic strategies for a targeted cancer therapy.

2003 • 55 citations

FRAP-p70s6K Signaling Is Required for Pancreatic Cancer Cell Proliferation

2001 • 53 citations

[22] Purification and properties of mitogen-activated S6 kinase from rat liver and 3T3 cells

1991 • 40 citations

Signaling networks and cell cycle control : the molecular basis of cancer and other diseases

2000 • 39 citations

PI3K-Related Kinases: Roles in Cell-Cycle Regulation and DNA Damage Responses

2003 • 17 citations

Rapamycin inhibits the constitutively active Frap-p70S6K pathway and autonomous cell growth in human pancreatic cancer cells

2000 • 16 citations