Nitric oxide and superoxide induced p53 and Bax accumulation during mesangial cell apoptosis

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1995 • 4,043 citations

A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds

1993 • 2,423 citations

Bcl-2 and the regulation of programmed cell death

1994 • 2,346 citations

Mechanisms and Functions of Cell Death

1991 • 2,061 citations

Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures.

1995 • 1,968 citations

Redox signaling: Nitrosylation and related target interactions of nitric oxide

1994 • 1,732 citations

Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation. Formation of novel nitrogen-containing oxidized lipid derivatives

1994 • 1,348 citations

C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2

1994 • 1,145 citations

Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures

1993 • 1,024 citations

Apoptosis: The Biochemistry and Molecular Biology of Programmed Cell Death*

1993 • 1,005 citations

Nitric oxide synthase: Aspects concerning structure and catalysis

1994 • 865 citations

Nitric oxide protects against cellular damage and cytotoxicity from reactive oxygen species.

1993 • 785 citations

Nitric oxide-mediated apoptosis in murine peritoneal macrophages

1993 • 782 citations

Nitric oxide-mediated apoptosis in murine peritoneal macrophages.

1993 • 674 citations

Glucocorticoids activate a suicide process in thymocytes through an elevation of cytosolic Ca2+ concentration

1989 • 549 citations

Mesangial cell apoptosis: the major mechanism for resolution of glomerular hypercellularity in experimental mesangial proliferative nephritis.

1994 • 406 citations

p53 expression in nitric oxide‐induced apoptosis

1994 • 403 citations

Some observations concerning the S-nitroso and S-phenylsulphonyl derivatives of L-cysteine and glutathione

1985 • 389 citations

Induction of bax by genotoxic stress in human cells correlates with normal p53 status and apoptosis.

1994 • 377 citations

Different prooxidant levels stimulate growth, trigger apoptosis, or produce necrosis of insulin-secreting RINm5F cells. The role of intracellular polyamines.

1994 • 372 citations

Nitric oxide induces apoptosis in mouse thymocytes.

1995 • 356 citations

Apoptotic Cell Death Triggered by Nitric Oxide in Pancreatic β-Cells

1995 • 343 citations

Peroxynitrite-induced Apoptosis in HL-60 Cells

1995 • 300 citations

Peroxynitrite‐Induced Cytotoxicity in PC12 Cells: Evidence for an Apoptotic Mechanism Differentially Modulated by Neurotrophic Factors

1995 • 292 citations

Chronic inhibition of superoxide dismutase produces apoptotic death of spinal neurons.

1994 • 291 citations

Molecular controls of growth arrest and apoptosis: p53-dependent and independent pathways.

1995 • 282 citations

Glomerulonephritis induced by monoclonal anti-Thy 1.1 antibodies. A sequential histological and ultrastructural study in the rat.

1986 • 262 citations

Extracellular superoxide dismutase, nitric oxide, and central nervous system O2 toxicity.

1992 • 245 citations

Nitric Oxide Regulation of Superoxide and Peroxynitrite-dependent Lipid Peroxidation

1994 • 244 citations

p53-catalyzed annealing of complementary single-stranded nucleic acids.

1993 • 225 citations

Bcl-2 Protects Macrophages from Nitric Oxide-induced Apoptosis

1996 • 224 citations

Genesis of renal tubular atrophy in experimental hydronephrosis in the rat. Role of apoptosis.

1987 • 193 citations

Overexpression of the death-promoting gene bax-alpha which is downregulated in breast cancer restores sensitivity to different apoptotic stimuli and reduces tumor growth in SCID mice.

1996 • 192 citations

Nitric oxide-induced apoptosis in RAW 264.7 macrophages is antagonized by protein kinase C- and protein kinase A-activating compounds.

1995 • 178 citations

Apoptosis in the repair process of experimental proliferative glomerulonephritis

1995 • 163 citations

Transforming growth factor β2 inhibits interleukin 1β- and tumour necrosis factor α-induction of nitric oxide synthase in rat renal mesangial cells

1991 • 162 citations

Nitric oxide mediates immunologic injury to kidney mesangium in experimental glomerulonephritis.

1995 • 154 citations

Interleukin 1 and tumor necrosis factor stimulate cGMP formation in rat renal mesangial cells

1990 • 142 citations

Interleukin 1β and tumour necrosis factor α induce a macrophage‐type of nitric oxide synthase in rat renal mesangial cells

1992 • 126 citations

Nitric Oxide Protects against Alkyl Peroxide-Mediated Cytotoxicity: Further Insights into the Role Nitric Oxide Plays in Oxidative Stress

1995 • 122 citations

The balance between nitric oxide and superoxide determines apoptotic and necrotic death of rat mesangial cells.

1997 • 105 citations

Nitric oxide donors induce apoptosis in glomerular mesangial cells, epithelial cells and endothelial cells

1996 • 96 citations

Cell death in the diseased glomerulus

1988 • 79 citations

Pyrrolidine Dithiocarbamate Differentially Affects Interleukin 1β- and cAMP-Induced Nitric Oxide Synthase Expression in Rat Renal Mesangial Cells

1994 • 74 citations

Glomerular NO synthase activity in mesangial cell immune injury.

1993 • 73 citations

Anti-Fas antibodies induce cytolysis and apoptosis in cultured human mesangial cells

1996 • 58 citations

The dual role of S-nitrosoglutathione (GSNO) during thymocyte apoptosis

1996 • 44 citations

Apoptosis is triggered by the cyclic AMP signalling pathway in renal mesangial cells

1996 • 33 citations

The effect of ACE inhibitors on the expression of matrix genes and the role of p53 and p21 (WAF1) in experimental renal fibrosis.

1996 • 33 citations

The Novel Regulatory Mechanism of Fas System-Mediated Apoptosis in Mesangial Cells: Implication to Mesangial Proliferative Glomerulonephritis

1996 • 9 citations

Deleted Work

1955 • 0 citations