Reaction of peptide aldehydes with serine proteases. Implications for the entropy changes associated with enzymic catalysis

On the size of the active site in proteases. I. Papain

1967 • 5,150 citations

The determination of enzyme inhibitor constants

1953 • 4,050 citations

Entropic Contributions to Rate Accelerations in Enzymic and Intramolecular Reactions and the Chelate Effect

1971 • 980 citations

Structure of the complex formed by bovine trypsin and bovine pancreatic trypsin inhibitor

1974 • 548 citations

A linear equation that describes the steady-state kinetics of enzymes and subcellular particles interacting with tightly bound inhibitors

1972 • 524 citations

Structure and mechanism of chymotrypsin

1976 • 449 citations

Crystal structure of the complex of porcine trypsin with soybean trypsin inhibitor (Kunitz) at 2.6 Å resolution

1974 • 431 citations

TRANSITION STATE ANALOG INHIBITORS AND ENZYME CATALYSIS

1976 • 415 citations

Three-dimensional Structure of Tosyl-elastase

1970 • 299 citations

Use of peptide aldehydes to generate transition-state analogs of elastase

1973 • 181 citations

Tertiary structural differences between microbial serine proteases and pancreatic serine enzymes

1975 • 132 citations

Entropy, Binding Energy, and Enzymic Catalysis

1977 • 114 citations

Dependence of the kinetic parameters for elastase-catalyzed amide hydrolysis on the length of peptide substrates

1973 • 110 citations

Spectrophotometric Investigations of the Mechanism of α-Chymotrypsin-catalyzed Hydrolyses. Detection of the Acyl-enzyme Intermediate^1-3

1962 • 104 citations

Amino acid sequence alignment of bacterial and mammalian pancreatic serine proteases based on topological equivalences

1978 • 96 citations

Binding of boronic acids to chymotrypsin

1974 • 84 citations

Hydration equilibria of some aldehydes and ketones

1960 • 80 citations

The active centers of Streptomyces griseus protease 3 and α-chymotrypsin: enzyme-substrate interactions remote from the scissile bond

1976 • 71 citations

Antiproteolytic aldehydes and ketones: substituent and secondary deuterium isotope effects on equilibrium addition of water and other nucleophiles

1977 • 68 citations

The Elastase‐Like Enzymes from Streptomyces griseus (Pronase)

1971 • 68 citations

Mechanism of the .alpha.-chymotrypsin-catalyzed hydrolysis of amides. pH dependence of kc and km. kinetic detection of an intermediate

1971 • 68 citations

Re-evaluation of the Kinetic Constants of Previously Investigated Specific Substrates of α-Chymotrypsin¹

1955 • 66 citations

Molecular structure of crystalline Streptomyces griseus protease A at 2.8 å resolution

1978 • 65 citations

Active centers of Streptomyces griseus protease 1, Streptomyces griseus protease 3, and α-chymotrypsin: enzyme-substrate interactions

1978 • 52 citations

4 Proximity Effects and Enzyme Catalysis

1970 • 48 citations

Binding of peptides to elastase. Implications for the mechanism of substrate hydrolysis

1974 • 47 citations

Crystallographic and kinetic investigations of the covalent complex formed by a specific tetrapeptide aldehyde and the serine protease from Streptomyces griseus.

1979 • 44 citations

Chymotrypsin catalysis. Evidence for a new intermediate, III

1973 • 44 citations

The Proteolytic Enzymes of the K-1 Strain of Streptomyces griseus Obtained from a Commercial Preparation (Pronase)

1973 • 38 citations

Mechanism of association of a specific aldehyde "transition-state analog" to the active site of .alpha.-chymotrypsin

1979 • 36 citations

[19] Peptide aldehydes: Potent inhibitors of serine and cysteine proteases

1977 • 29 citations

Mechanism of the .alpha.-chymotrypsin-catalyzed hydrolysis of specific amide substrates

1972 • 25 citations

The α-Chymotrypsin-catalyzed Hydrolysis of α-N and O-Alkyl Derivatives of α-N-Acetyl-L-tyrosine Methyl Ester^*

1963 • 23 citations

Studies on Streptomyces griseus protease III. Purification of two DFP-reacting enzymes

1969 • 22 citations

The Disulfide Bridge Sequences of a Serine Protease of Wide Specificity from Streptomyces griseus

1971 • 21 citations

The binding of specific and non‐specific aldehyde substrate analogs to α‐chymotrypsin

1975 • 21 citations

The binding of a non‐specific ‘transition state analogue’ to α‐chymotrypsin

1975 • 19 citations

The binding of inhibitors to α-chymotrypsin at alkaline pH

1967 • 18 citations

Evidence for hemiacetal formation between α-chymotrypsin and hydrocinnamaldehyde by cross-saturation nuclear magnetic resonance spectroscopy

1977 • 17 citations

Studies of the Heterogeneity of Streptomyces griseus Protease. Isolation and Characterization of an Alkaline Serine Protease from Commercial Pronase-P Derived from Streptomyces griseus Kl.

1973 • 15 citations

NMR evidence against covalent attachment of an aldehyde ‘transition-state’ analogue to α-chymotrypsin

1976 • 10 citations

Purity and pH-Dependence of Streptomyces griseus Protease 1.

1977 • 6 citations