Studies on the mechanisms of induction of N-nitrosodimethylamine demethylase by fasting, acetone, and ethanol

Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase.

1976 • 1,343 citations

Carcinogenic Nitroso Compounds

1967 • 1,109 citations

Formation of N-nitroso compounds: Chemistry, kinetics, and in vivo occurrence

1975 • 759 citations

Separation and purification of multiple forms of microsomal cytochrome P-450. Activities of different forms of cytochrome P-450 towards several compounds of environmental interest.

1977 • 367 citations

Microsomal metabolism of dimethylnitrosamine and the cytochrome P-450 dependency of its activation to a mutagen.

1973 • 212 citations

The decomposition and toxicity of dialkylnitrosamines in rats

1962 • 200 citations

High-affinity nitrosamine dealkylase system in rat liver microsomes and its induction by fasting.

1983 • 160 citations

Ketone Body Metabolism in the Ketosis of Starvation and Alloxan Diabetes

1970 • 159 citations

Enhancement of dimethylnitrosamine metabolism and activation to a mutagen following chronic ethanol consumption.

1981 • 156 citations

Formation in vivo of volatile N-nitrosamines in man after ingestion of cooked bacon and spinach

1977 • 130 citations

The induction and competitive inhibition of a high affinity microsomal nitrosodimethylamine demethylase by ethanol

1982 • 127 citations

Enhanced hepatotoxicity of carbon tetrachloride, thioacetamide, and dimethylnitrosamine by pretreatment of rats with ethanol and some comparisons with potentiation by isopropanol

1975 • 120 citations

Dialkylnitrosamine bioactivation and carcinogenesis

1980 • 99 citations

Direct Blood-Injection Method for Gas Chromatographic Determination of Alcohols and Other Volatile Compounds

1971 • 93 citations

Toxic liver injury. The metabolism of dimethylnitrosamine in vitro

1958 • 92 citations

Dose-related effects of a single dose of ethanol on the metabolism in rat liver of some aromatic and chlorinated hydrocarbons

1981 • 86 citations

Relationship of alcohol metabolism to the potentiation of CCl 4 hepatotoxicity induced by aliphatic alcohols.

1972 • 85 citations

Induction of a high affinity nitrosamine demethylase in rat liver microsomes by acetone and isopropanol

1983 • 78 citations

Pyrazole-induced cytochrome P-450 in rat liver microsomes: An isozyme with high affinity for dimethylnitrosamine

1981 • 72 citations

Alterations of microsomal monooxygenase system and carcinogen metabolism by streptozotocin-induced diabetes in rats

1983 • 69 citations

Analysis of volatile N-nitrosamines in alcoholic beverages

1979 • 65 citations

Studies on the in vitro metabolism of dimethylnitrosamine by rat liver

1976 • 63 citations

Effects of ethanol on hepatic microsomal drug-metabolizing enzymes in the rat

1975 • 62 citations

Interactions between solubilized cytochrome P-450 and hepatic microsomes.

1977 • 61 citations

The effect of temperature on monoxygenase reactions in the microsomal membrane

1977 • 52 citations

Some Studies on the Metabolism in vitro of Dimethylnitrosamine by Rat Liver

1974 • 50 citations

Effect of a single oral dose of methanol, ethanol and propan-2-ol on the hepatic microsomal metabolism of foreign compounds in the rat

1975 • 47 citations

Interactions between solubilized cytochrome P 450 and hepatic microsomes. Characterizations of the binding and the enhanced catalytic activities

1977 • 40 citations

Substrates and inhibitors of hepatic amine oxidase inhibit dimethylnitrosamine-induced mutagenesis in Salmonella typhimurium

1980 • 37 citations

Role of dimethylnitrosamine-demethylase in the metabolic activation of dimethylnitrosamine

1979 • 36 citations

Stimulation of microsomal dimethylnitrosamine-N-demethylase by pretreatment of mice with acetone

1978 • 35 citations

Investigations into the hepatic metabolism of dimethylnitrosamine in the rat

1975 • 35 citations

Isopropanol and acetone potentiation of carbon tetrachloride‐induced hepatotoxic1ty: Single versus repetitive pretreatments in rats

1982 • 33 citations

Acetone potentiation of 1,1,2-trichloroethane hepatotoxicity

1982 • 29 citations

Effect of acetone administered in vivo upon hepatic microsomal drug metabolizing activity in the rat

1974 • 29 citations

The effect of ethanol administration on renal and hepatic mixed-function oxidases in the Fischer 344 rat

1982 • 6 citations

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